Безинтерфероновая терапия хронического гепатита С: смена препаратов или новая парадигма лечения?
Аннотация
Цель обзора. Критическая оценка безинтерфероновых схем противовирусной терапии (ПВТ) хронического гепатита С (ХГС) на основании анализа данных клинических исследований.
Основные положения. Безинтерфероновые варианты лечения ХГС имеют определенные преимущества над схемами терапии, включающими интерферон-α. Монотерапия препаратами с прямым воздействием на вирус менее эффективна по сравнению с их комбинированным применением. Комбинирование агентов с прямым противовирусным действием значительно снижает риск резистентности, увеличивая вероятность эрадикации вируса. Роль рибавирина при различных безинтерфероновых режимах терапии нуждается в уточнении.
Заключение. Новые варианты ПВТ, предусматривающие комбинированное применение препаратов с прямым противовирусным действием (без использования интерферона и рибавирина), позволят существенно упростить схемы, сократить сроки и повысить эффективность лечения у всех категорий пациентов. Такие варианты терапии можно считать новой парадигмой лечения ХГС.
Об авторе
C. Н. Бацких
ФБУН «Центральный НИИ эпидемиологии» Роспотребнадзора
Россия
Россия
Бацких Сергей Николаевич – кандидат медицинских наук, научный сотрудник
111123, Москва, ул. Новогиреевская, д. 3а
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Рецензия
Для цитирования:
Бацких C.Н. Безинтерфероновая терапия хронического гепатита С: смена препаратов или новая парадигма лечения? Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2014;24(4):23-31.
For citation:
Batskikh S.N. Interferon-free therapy of chronic hepatitis C: replacement of medications or new treatment paradigm? Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;24(4):23-31. (In Russ.)
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