Drug-induced liver injuries (Part 1)
Abstract
The aim of review. To present modern concepts on mechanisms of drug-induced liver injury (DILI), to give their classification, to present approaches to disease diagnostics.
Original positions. DILI can progress under the mask of all known acute and chronic liver diseases. Pharmaceuticals act as one of the leading causes of development of fulminant liver failure in many countries of the world. Early diagnostics and well-timed cancellation of the drug causing liver damage, allow to prevent disease progression. Careful collection of medicinal past history, ruling out of other possible causes of liver injury and application of diagnostic scales (CIOMS/ RUCAM) lays in a basis of DILI diagnostics.
Conclusion. Drug-induced lesions occupies significant place in major spectrum of liver diseases, welltimed diagnostics of these lesions enables to exclude intake of the respective agents.
About the Author
S. F. Galimova
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university» Ministry of Health and Social Development of Russia
Russian Federation
Russian Federation
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Review
For citations:
Galimova S.F. Drug-induced liver injuries (Part 1). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2012;22(3):38-48. (In Russ.)
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