Drug-induced lesion of the liver: general-purpose morphological markers
Abstract
Aim of investigation. To determine morphological markers of hepatotoxic effect of narcotics at drug addiction and effect of some groups of drugs at patients with chronic liver and kidneys diseases at positive markers HCV-and HBV-infections.
Materials and methods. Retrospective analysis of 4 groups of patients with HCV-and the HBV-infection markers with various hepatotoxic injuries: by narcotic drugs, biltricid (antihelminthic) at chronic opisthorchiasis, long programmed polychemotherapy of hemoblastoses, immune suppressive therapy for «chronic renal disease» was carried out.
Results. General morphological markers of hepatotoxic damage – macrovesicular lipid infiltration of hepatocytes, intrahepatocellular cholestasis, centrilobular necroses, central (metabolic) and perisinusoidal fibrosis. Endocellular remodeling of hepatocytes includes hyperplasia of agranular cytoplasmic reticulum associated with reduction of protein-synthesizing organellas, as well as destruction and compensatory hyperplasia of mitochondrial compartment. New ultrastructural phenomena of hepatotoxicity were defined which can be related to compensatory and adaptive responses of hepatocytes: interaction of smooth and granular cytoplasmic reticulum aimed on increased metabolism of xenobiotics, «autonomism» of hepatocytes with increase of cytolemma surface, providing parenchymatous – sinusoidal balance in conditions of perisinusoidal fibrosis.
Conclusion. Application of cytotoxic drugs results in the significant lesion of liver starting with centrilobular zone, – dystrophias, hepatocyte necrosis and reactive fibrosis.
About the Authors
V. T. IvashkinRussian Federation
G. I. Nepomnyaschykh
Russian Federation
S. V. Aydagulova
Russian Federation
D. L. Nepomnyaschykh
Russian Federation
G. A. Dyubanova
Russian Federation
N. P. Domnikova
Russian Federation
Ye. I. Migus’kina
Russian Federation
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For citations:
Ivashkin V.T., Nepomnyaschykh G.I., Aydagulova S.V., Nepomnyaschykh D.L., Dyubanova G.A., Domnikova N.P., Migus’kina Ye.I. Drug-induced lesion of the liver: general-purpose morphological markers. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(2):20-29. (In Russ.)
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