Efficacy of application of alginates in treatment of a heartburn at pregnant women
Abstract
Aim of investigation. To estimate frequency, factors of development of heartburn at pregnant women, to determine approach of pharmaceutical treatment by alginates.
Material and methods. At 110 pregnant women frequency and severity of heartburn were estimated by Likert scale, anthropometry and esophagogastroduodenoscopy at presence of heartburn were carried out.
Results. General frequency of symptom of heartburn in studied group was 56,4%. The weekly heartburn was revealed at every other pregnant woman (49,1%). The greatest effect on its development had: presence of heartburn prior pregnancy, excessive body weight or obesity before and during pregnancy, presence of the relatives having heartburn, presence of heartburn during previous pregnancy, smoking before pregnancy. Frequency and severity of heartburn without pharmacological correction grew along with gestation term. On a background of Gaviscon forte treatment 10 ml/day in on-demand mode by the 4-th week of the study significant decrease of total frequency and severity of heartburn, complete relief of weekly, daily and night heartburn was observed.
Conclusion. The heartburn is a frequent symptom at pregnancy, alginic acid drug can be successfully utilised for its treatment.
About the Authors
E. V. OnuchinaRussian Federation
E. A. Gorobets
Russian Federation
A. A. Rozhansky
Russian Federation
V. V. Tsukanov
Russian Federation
References
1. Anton C., Anton E., Drug V.L., Stanciu C. Hormonal influence on gastrointestinal reflux during pregnancy // Rev. Med. Chir. Soc. Med. Nat. Iasi. – 2003. – Vol. 107. – P. 798–801.
2. Bor S., Kitapcioglu G., Dettmar P., Baxter T. Association of heartburn pregnancy with the risk of gastroesophageal reflux disease // Clin. Gastroenterol. Hepatol. – 2007. – Vol. 5. – P. 1035–1039.
3. Dowswell T., Neilson J.P. Interventions for heartburn in pregnancy // Cochrane Database Syst. Rev. – 2008. Oct. 8; (4):CD007065.
4. Eslick G.D., Talley N.J. Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life-a population-based study // J. Clin. Gastroenterol. – 2009. – Vol. 43. – P. 111–117.
5. Fil S., Malfertheiner M., Costa S.D., Monkemuller K. Handling of the gastroesophageal reflux disease (GERD) during pregnancy-a review // Z. Geburtshilfe Neonatol. – 2007. – Vol. 211. – P. 215–223.
6. Gill S.K., OўBrien L., Einarson T.R., Koren G. The safety of proton pump inhibitors (PPIs) in pregnancy: a meta-analysis // Am. J. Gastroenterol. – 2009. – Vol. 104. – P. 1541–1545.
7. Hatlebakk J.G. Treatment of gastroesophageal reflux in pregnant women // Tidsskr. Nor. Laegeforen. – 2004. – Vol. 124. – P. 797–798.
8. Keller J., Frederking D., Layer P. The spectrum and treatment of gastrointestinal disorders during pregnancy // Nat. Clin. Pract. Gastroenterol. Hepatol. – 2008. – Vol. 5. – P. 430–433.
9. Lindow S.W., Regnell P., Sykes J., Little S. An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy // Int. J. Clin. Pract. – 2003. – Vol. 3. – P. 175–179.
10. Mahadevan U., Kane S. American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy // Gastroenterology. – 2006. – Vol. 131. – P. 278–282.
11. Mandel K.G., Daggy B.P., Brodie D.A., Jacoby H.I. Review article: alginate-raft formulation in the treatment of heartburn and acid reflux // Aliment. Pharmacol. Ther. – 2000. – Vol. 14. – P. 669–690.
12. Marrero J.M., Goggin P.M., de Caestecker J.S. et al. Determinants of pregnancy heartburn // Br. J. Obstet. Gynaecol. – 1992. – Vol. 99. – P. 731–734.
13. Nocon M., Labenz J., Jaspersen D. et al. Association of body mass index with heartburn, regurgitation and esophagitis: results of the progression of gastroesophageal reflux disease study // J. Gastroenterol. Hepatol. – 2007. – Vol. 22. – P. 1728–1731.
14. Rey E., Rodriguez-Artalejo F., Herraiz M.A. et al. Gastroesophageal reflux symptoms duiring and after pregnancy: a longitudinal study // Am. J. Gastroenterol. – 2007. – Vol. 102. – P. 2395–2400.
15. Richter J.E. Review article: the management of heartburn in pregnancy // Aliment. Pharmacol. Ther. – 2005. – Vol. 22. – P. 749–757.
16. Tytgat G.N., Heading R.C., Muller-Lissner S. et al. Contemporary understanding and management of reflux and constipation in the general population and pregnancy: a consensus meetin // Aliment. Pharmacol. Ther. – 2003. – Vol. 18. – P. 291–301.
17. Vakil N., van Zanten S., Kahrilas P. et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am. J. Gastroenterol. – 2006. – Vol. 101. – P. 1900–1920.
Review
For citations:
Onuchina E.V., Gorobets E.A., Rozhansky A.A., Tsukanov V.V. Efficacy of application of alginates in treatment of a heartburn at pregnant women. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(6):23-27. (In Russ.)
Views:
20
Email this article 
