Кишечный микробиом - основной фактор поддержания здоровья и развития болезней человека
Аннотация
Цель обзора. Отразить современные представления о роли микробиома в поддержании здоровья человека и развитии различных заболеваний. Краткое содержание. Благодаря современным достижениям молекулярной и клеточной биологии существенно расширились наши представления о патогенезе многих заболеваний человека и разработаны новые подходы к их диагностике, лечению и профилактике. На основе результатов современных молекулярных, генетических, эпигенетических, микробиологических и биохимических исследований стало возможным, с одной стороны, изучать точечные мутации и варианты полиморфизма отдельных нуклеотидов в рамках полногеномного анализа, с другой - с помощью высокоточного анализа и других методик проводить одновременное исследование тысяч генов (анализ ДНК) или их производных (РНК и белки) с созданием индивидуального профиля самих генов или их экспрессии («генетическая подпись»), а также осуществлять анализ индивидуального микробиома пациента с оценкой его патогенного потенциала. Подобные исследования позволяют все чаще проводить оценку индивидуальной предрасположенности к заболеваниям, прогноза болезни и эффективности выбранной стратегии лечения («персонализированная медицина»). Заключение. Исследование микробиома человека, а также полногеномные исследования способствуют достижению новых успехов в диагностике, лечении и профилактике заболеваний человека.
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Рецензия
Для цитирования:
Хуберт Е.Б. Кишечный микробиом - основной фактор поддержания здоровья и развития болезней человека. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2017;27(5):4-10. https://doi.org/10.22416/1382-4376-2017-27-5-4-10
For citation:
Hubert E.B. INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):4-10. (In Russ.) https://doi.org/10.22416/1382-4376-2017-27-5-4-10
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