Trimebutine in the treatment of GIT electrical activity disorders at experimental endotoxemia
Abstract
Aim of investigation. To study the effect of trimebutine on electrical activity of organs of gastro-intestinal tract (GIT) in postoperative period at endotoxemia state.
Materials and methods. The study was carried out at 13 nubilous Wistar male rats. Animal had a tube in jejunum and electrodes — in the wall of stomach antrum, duodenum and jejunum — implanted during laparotomy. Solution of lipopolysaccharide of Escherichia coli serotype 055:B5 in a dose of 200 mkg/kg was injected intraoperatively into femoral vein. Two groups of rats were studied: the first had single injection of 0,2 ml normal saline solution intraintestinally for the first 3 days after operation (control group, n=7) while the second — 0,2 ml of trimebutine solution in a dose of 2,86 mg/kg (main group, n=6). Electrical activity of investigated regions of GIT was recorded by electromyography for one hour (background) and for 2 hs after injection of medicine.
Results. In the control group during 3 days after operation significant decrease in score of antroduodenal coordination and absence of phase III of migrating myoelectric complex (MMC) in duodenum and jejunum was observed. On the 2 and 3 day appearance of pathological motility patterns: high-amplitude spastic activity and giant migrating spikes (GMS) in duodenum and jejunum was marked. Normalization of antroduodenal coordination and MMC was noticed only to the 8-th day after surgery. In the main group injection of trimebutine during 3 days after operation cardinally changed dynamics of electrical activity of GIT regions. Already on the 3-rd day in background records the score of antroduodenal coordination did not differ from normal values. On the 4-th day in duodenum and jejunum MMC was recorded. In postoperative period in all terms no episodes of high-amplitude spastic activity or GMS were observed.
Conclusions. In early postoperative period in conditions of endotoxemia there are significant disorders in MMC generation with appearance of pathological motility patterns like GMS and spasmodic activity. Injection of trimebutine in these conditions is effective, that is proved by absence of pathological patterns of motility, more rapid normalization of antroduodenal coordination and faster restoration of MMC spread from duodenum to jejunum.
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Review
For citations:
Tropskaya N.S., Popova T.S. Trimebutine in the treatment of GIT electrical activity disorders at experimental endotoxemia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(2):37-42. (In Russ.)
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