Efficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipients
https://doi.org/10.22416/1382-4376-2017-27-5-65-68
Abstract
Aim. To estimate efficacy and safety of direct antiviral drugs for hepatitis C treatment in donor lung recipients. Key points. The first cases in Russian literature and one of the first-ever cases of hepatitis C treatment by direct antiviral agents in lung transplant recipients are presented. Combined therapy by asunaprevir and daclatasvir for 24 weeks resulted in sustained virologic response. No significant adverse effects on drug to drug interactions, except for mild and controllable alteration of tacrolimus blood level, were noted. Conclusion. Daclatasvir and asunaprevir combination is effective and safe treatment mode for hepatitis C in donor lung recipients
About the Authors
D. T. Abdurakhmanov
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Ye. . Sidorova
Federal state educational government-financed institution of higher education «Lomonosov Moscow State University»
Russian Federation
Russian Federation
I. N. Tikhonov
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
N. A. Mukhin
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
V. T. Ivashkin
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Abdurakhmanov D.T., Sidorova Ye., Tikhonov I.N., Mukhin N.A., Ivashkin V.T. Efficacy of daclatasvir and asunaprevir for viral hepatitis С in two donor lung recipients. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):65-68. (In Russ.) https://doi.org/10.22416/1382-4376-2017-27-5-65-68
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