Метаболизм желчных кислот, заболевания печени и микробиом
https://doi.org/10.22416/1382-4376-2018-28-2-4-10
Аннотация
Цель обзора. Представить современные данные о взаимосвязи метаболизма желчных кислот (ЖК), микробиома и заболеваний печени. Основные положения. ЖК - важные сигнальные молекулы, регулирующие метаболизм липидов и глюкозы. Энтерогепатическая циркуляция ЖК занимает центральное место в абсорбции нутриентов и их метаболической регуляции. Результаты исследований свидетельствуют о взаимосвязи ЖК, кишечного микробиома и заболеваний печени. В частности, хорошо изучена роль нарушения метаболизма ЖК в развитии неалкогольной жировой болезни печени. Практический интерес представляют секвестранты ЖК, которые продолжают изучать как регуляторы метаболизма ЖК и глюкозы. Заключение. ЖК выполняют разнообразные функции в организме. Результаты многочисленных работ демонстрируют тесную связь между метаболизмом ЖК, патологией печени и кишечным микробиомом.
Об авторах
Ю. В. Евсютина
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет); ФГБУ «Национальный медицинский исследовательский центр профилактической медицины»
Россия
Россия
В. Т. Ивашкин
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет)
Россия
Россия
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Рецензия
Для цитирования:
Евсютина Ю.В., Ивашкин В.Т. Метаболизм желчных кислот, заболевания печени и микробиом. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2018;28(2):4-10. https://doi.org/10.22416/1382-4376-2018-28-2-4-10
For citation:
Yevsyutina Yu.V., Ivashkin V.T. Metabolism of bile acids, liver diseases and microbiome. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(2):4-10. (In Russ.) https://doi.org/10.22416/1382-4376-2018-28-2-4-10
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