Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases
https://doi.org/10.22416/1382-4376-2019-29-4-15-21
Abstract
Despite the similarity of many pathogenetic lesions of the gastrointestinal tract and the oral cavity, there remain unresolved issues related to the etiology and pathogenesis of dental diseases associated with inflammatory bowel diseases.
Aim. Analysis and systematization of literature data on the problem of combined diseases of the oral cavity and the gastrointestinal tract.
Key findings. Severe recurrent inflammatory bowel disease and the close relationship of all levels of the digestive tube create prerequisites for the development of pathological processes in the oral cavity. Despite the extensive symptoms of oral manifestations of inflammatory bowel disease, aphthous stomatitis is considered more often than other diseases. There are different opinions about the involvement of the oral mucosa in the pathological process in inflammatory bowel disease. Some authors consider the defeat of the mouth in terms of the specific localization of Crohn’s disease, others see in it only extraintestinal manifestations of the disease, along with changes in the skin, joints and eyes. Immunohistochemical studies allow you to answer individual questions of pathogenesis.
Conclusion. The presented analysis of publications confirms the morphofunctional unity of various parts of the digestive system, which determines the complex mechanisms of the development of combined diseases.
About the Authors
N. S. Robakidze
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Dr. Sci.(Med.), Assoc. Prof., Department of orthopedic dentistry
191015, Saint Petersburg, Kirochnaya str., 4
O. B. Shchukina
Pavlov First Saint Petersburg State Medical University,
City Centre of Diagnosis and Treatment of Inflammatory Bowel Disease, City Clinical Hospital No. 31
Russian Federation
Russian Federation
Dr. Sci.(Med.), Assoc. Prof., Department of General Practice; Research supervisor
197110, Saint Petersburg, Dinamo ave., 3.
References
1. Grigorieva G.A., Meshalkina N.Yu. On the problem of systemic manifestations of inflammatory bowel diseases. Farmateka. 2011;15(228): 14–49 (In Rus.)
2. Maev I.V., Bazikyan E.A., Tsarev V.N., Lukina G.I., Mukhina E.V. Oral microflora with different pH of mixed saliva in patients with acid-related diseases. Critical Medicine. 2008;3:31–4 (In Rus.)
3. Logan R.M. Links between oral and gastrointestinal health. Curr Opin Support Palliat Care. 2010;4(1):31–5.
4. Jajam M., Bozzolo P., Niklander S. Oral manifestations of gastrointestinal disorders. J Clin Exp Dent. 2017;9(10):1242–8.
5. Larsen S., Bendtzen K., Nielsen O.H. Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann Med. 2010; 42(2):97–114.
6. Girlich C., Bogenrieder T., Palitzsch K.D., Schölmerich J., Lock G. Orofacial granulomatosis as initial manifestation of Crohn’s disease: a report of two cases. Eur J Gastroenterol Hepatol. 2002;14(8):873–6.
7. Femiano F., Lanza A., Buonaiuto C., Perillo L., Dell’Ermo A., Cirillo N. Pyostomatitisvegetans: a review of the literature. Med Oral Patol Oral Cir Bucal. 2009;14(3):E114–7.
8. Ivashkin V.T., Shelygin Yu.A., Khalif I.L., Belousova E.A., Shifrin O.S., Abdulganieva D.I. et al. Clinical recommendations of the Russian Gastroenterological Association and the Association of Coloproctologists of Russia for the diagnosis and treatment of Crohn’s disease. Coloproctology. 2017;2(60):7–29. (In Rus.)
9. Fiocchi C. Inflammatory bowel disease pathogenesis: Where are we? J Gastroenterol Hepatol. 2015;30 Suppl 1:12–8.
10. Harikishan G., Reddy N.R., Prasad H., Anitha S. Oral Crohn’s disease without intestinal manifestations. J Pharm. Bioallied Sci. 2012;4 (Suppl 2):S431–4.
11. Lourenço S.V, Hussein T.P., Bologna S.B., Sipahi A.M., Nico M.M. Oral manifestations of inflammatory bowel disease: a review based on the observation of six cases J Eur Acad Dermatol Venereol. 2010;24(2):204–7.
12. Fatahzadeh M., Schwartz R.A., Kapila R., Rochford C. Orofacial Crohn’s disease: an oral enigma. Acta Dermatovenerol Croat. 2009;17(4):289–300.
13. Lebedenko I.Yu., Maev I.V., Mulyar E.A. Manifestation of nonspecific ulcerative colitis and Crohn’s disease in the oral cavity. Russian dental journal. 2002;6:42–5 (In Rus.)
14. Nakajima S., Iijima H., Egawa S., Shinzaki S., Kondo J., Inoue T., Hayashi Y., Ying J., Mukai A., Akasaka T., Nishida T., Kanto T., Tsujii M., Hayashi N. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011;27(10):1023–8.
15. Bronner F. Mechanisms of intestinal calcium absorption. J Cell Biochem. 2003;88(2):387–93.
16. Fang Y., Hu C., Tao X., Wan Y., Tao F. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials. J Bone Miner Metab. 2012;30(1):60–8.
17. Galbraith S.S., Drolet B.A., Kugathasan S., Paller A.S., Esterly N.B. Asymptomatic inflammatory bowel disease presenting with mucocutaneous findings. Pediatrics. 2005;116(3):439–44.
18. Ardizzone S., Puttini P.S., Cassinotti A., Porro G.B. Extraintestinal manifestations of inflammatory bowel disease. Dig Liver Dis. 2008;40, Suppl. 2:S253–9.
19. Levine J.S., Burakoff R. Extraintestinal manifestations of inflammatory bowel diseases 2011. Gastroenterol Hepatol (N Y). 2011;7(4):235–41.
20. Williams H., Walker D., Orchard T.R. Extraintestinal manifestations of inflammatory bowel disease. Curr Gastroenterol Rep. 2008;10(6):597–605.
21. Mortada I., Leone A., Gerges Geagea A., Mortada R., Matar C., Rizzo M., Hajj Hussein I., Massaad-Massade L., Jurjus A. Oral manifestations of inflammatory bowel disease. J Biol Regul Homeost Agents. 2017;31(3):817–21.
22. Lankarani K.B., Sivandzadeh G.R., Hassanpour S. Oral manifestation in inflammatory bowel disease: A review. World J Gastroenterol. 2013;19(46):8571–9.
23. Burisch J., Munkholm P. Inflammatory bowel disease epidemiology. Scand J Gastroenterol. 2015;50(8):942–51.
24. Adler J., Rangwalla S.C., Dwamena B.A., Higgins P.D. The prognostic power of the NOD2 genotype for complicated Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2011;106(4):699–712.
25. Frolkis A., Dieleman L.A., Barkema H.W., Panaccione R., Ghosh S., Fedorak R.N., Madsen K., Kaplan G.G.; Alberta IBD Consortium. Environment and the inflammatory bowel diseases. Can J Gastroenterol. 2013;27(3):18–24.
26. Deas D.E., Mackey S.A., McDonnell H.T. Systemic disease and periodontitis: manifestations of neutrophil dysfunction. Periodontol 2000. 2003;32:82–104.
27. Singhal S., Dian D., Keshavarzian A., Fogg L., Fields JZ., Farhadi A. The role of oral hygiene in inflammatory bowel disease. DigDisSci. 2011;56(1):170–5.
28. Nagpal S., Acharya A.B., Thakur S.L. Periodontal disease and anemias associated with Crohn’s disease. A case report. N Y State Dent J. 2012;78(2):47–50.
29. Ojha J., Cohen D.M., Islam N.M., Stewart C.M., Katz J., Bhattacharyya I. Gingival involvement in Crohn’s disease. J Am Dent Assoc. 2007;138(12):1574–81.
30. Brito F., Zaltman C., Carvalho A.T., Fischer R.G., Persson R., Gustafsson A., Figueredo C.M. Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis. Eur. J. Gastroenterol. Hepatol. 2013;25(2):239–45.
31. Osipova Yu. L. The role of violations of cell proliferation and apoptosis in the pathogenesis of inflammatory periodontal diseases in the background of gastroesophageal reflux disease. Saratov Journal of Medical Scientific; 2013;3:449–53 (In Rus.)
32. Lepilin A.V., Osadchuk M.A., Karabushina Ya. G. Pathogenetic features of inflammatory periodontal diseases in irritable bowel syndrome. Successes of modern science. 2003;8:99 (In Rus.)
33. Guilarte M., Santos J., de Torres I., Alonso C., Vicario M., Ramos L., Martínez C., Casellas F., Saperas E., Malagelada J.R. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut. 2007;56(2):203–9.
34. Pujari R., Vidya N. Mast cell density in oral submucous fibrosis: a possible role in pathogenesis. In. J Health Sci (Qassim). 2013;7(1):23–9.
35. Ganganna K., Shetty P., Shroff S.E. Collagen in histologic stages of oral submucous fibrosis: A polarizing microscopic study. J. Oral. Maxillofac. Pathol. 2012;16(2):162–6.
36. Walsh L.J. Mast cell and oral inflammation. Crit. Rev. Oral Biol Med. 2003;14(3):188–98.
37. Rabinovich O.F., Rabinovich I.M., Panfilova E.L., Vakhrushina E.V. Recurrent aphthous stomatitis — etiology, pathogenesis (part I). Dentistry 2010; 1: 71–74 (In Rus.)
38. Preeti L., Magesh K., Rajkumar K., Karthik R. Recurrent aphthous stomatitis. J. Oral. Maxillofac. Pathol. 2011;15(3):252–6.
39. Chavan M., Jain H., Diwan N., Khedkar S., Shete A., Durkar S. Recurrent aphthous stomatitis: a review. J Oral Pathol Med. 2012;41(8):577–83.
40. Koybasi S., Parlak A.H., Serin E., Yilmaz F., Serin D. Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol. 2006;27(4):229–32.
41. Rabinovich O.F., Babichenko I.I., Rabinovich I.M., Kovyazin V.A., Vakhrushina E.V. Immunomorphology of recurrent aphthous stomatitis. Pathology Archive 2012;2:23–5 (In Rus.)
42. Bushueva T.V., Ron’ G.I., Chernysheva N.D. The role of cytokines in the development of chronic recurrent aphthous stomatitis. Ural Medical Journal. 2010;8(73):9–10 (In Rus.)
43. Duerksen D.R., Fallows G., Bernstein C.N. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition. 2006;22(11–12):1210–3.
44. Lopez-Jornet P., Gomez-Garcia F., Camacho-Alonso F. Pyostomatitis vegetans. Clinical marker of ulcerative colitis. N.-Y. State Dent J. 2012;78(2):36–7.
45. Michailidou E., Arvanitidou S., Lombardi T., Kolokotronis A., Antoniades D., Samson J. Oral lesions leading to the diagnosis of Crohn’s disease: report on 5 patients. Quintessence Int. 2009;40(7):581–8.
46. Freysdottir J., Zhang S., Tilakaratne W.M., Fortune F. Oral biopsies from patients with orofacial granulomatosis with histology resembling Crohn’s disease have a prominent Th1 environment. Inflamm. Bowel Dis. 2007;13(4):439–45. 47. Zbar A.P., Ben-Horin S., Beer-Gabel M., Eliakim R. Oral Crohn’s disease: is it a separable disease from orofacial granulomatosis? A review. J Crohns Colitis. 2012;6(2):135–42.
47. Levine J.S., Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterol Hepatol (N.-Y.). 2011;(4):235–41.
48. Harbord M., Annese V., Vavricka S.R., Allez M., Barreiro-de Acosta M., Boberg K.M., Burisch J., De Vos M., De Vries A.M., Dick A.D., Juillerat P., Karlsen T.H., Koutroubakis I., Lakatos P.L., Orchard T., Papay P., Raine T., Reinshagen M., Thaci D., Tilg H., Carbonnel F. European Crohn’s and Colitis Organisation. The First European Evidence-based Consensus on Extraintestinal Manifestations in Inflammatory Bowel Disease. J Crohns Colitis. 2016;10(3):239–54.
49. Robakidze N. S., Baranovsky A. Yu., Schukina O. B., Kiseleva E. B. Differential diagnostic criteria for Crohn’s disease and ulcerative colitis based on the state of the oral mucosa. Institute of Dentistry. 2014;3(64):58–59 (In Rus.)
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For citations:
Robakidze N.S., Shchukina O.B. Pathogenetic Aspects of Oral Cavity Lesions in Inflammatory Gastrointestinal Tract Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(4):15-21. (In Russ.) https://doi.org/10.22416/1382-4376-2019-29-4-15-21
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