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Российский журнал гастроэнтерологии, гепатологии, колопроктологии

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Персонализированный подход в гастроэнтерологии и гепатологии: достижения 2016 года

https://doi.org/10.22416/1382-4376-2016-26-3-4-10

Полный текст:

Аннотация

Последние достижения клеточной и молекулярной биологии позволили сделать существенный рывок в понимании патогенеза многих заболеваний, их диагностики, лечения и профилактики. С помощью современных методов молекулярного, генетического, эпигенетического, микробиологического и биохимического анализа, в том числе в рамках полного исследования генома человека, мы получили возможность выявлять диагностически значимые точечные мутации или полиморфизм отдельных нуклеотидов. С помощью высокопроизводительного анализа нуклеотидных последовательностей стало возможным проведение одновременного исследования тысяч генов (ДНК) или молекул, связанных с генами (РНК, белки), что позволяет определить индивидуальный генетический профиль больного («генетическую подпись») или оценить индивидуальные особенности микробиома, включая его патогенный потенциал. Подобная информация позволяет определить индивидуальную предрасположенность к заболеваниям, более точно установить прогноз болезни и определить эффективность выбранной стратегии лечения («персонализированная медицина»). Все указанные методы уже сегодня дают возможность улучшить диагностику, лечение и профилактику многих заболеваний человека.

Об авторе

Э. Блюм Хуберт
Клиника Фрайбургского университета
Россия


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Для цитирования:


Хуберт Э.Б. Персонализированный подход в гастроэнтерологии и гепатологии: достижения 2016 года. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016;26(3):4-10. https://doi.org/10.22416/1382-4376-2016-26-3-4-10

For citation:


Hubert E.B. Advances in personalized gastroenterology and hepatology 2016. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(3):4-10. (In Russ.) https://doi.org/10.22416/1382-4376-2016-26-3-4-10

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ISSN 1382-4376 (Print)
ISSN 2658-6673 (Online)