European Society for Neurogastroenterology and Motility Consensus on Gastroparesis: What Issues Remain Unresolved?
https://doi.org/10.22416/1382-4376-2022-32-4-89-94
Abstract
Aim: to analyse the document of the European Society for Neurogastroenterology and Motility consensus on gastroparesis, held in 2020.
Key findings. The evaluation of the voting results on the submitted statements of the consensus meeting shows that there is a high level of agreement among the experts regarding the definition of gastroparesis, the main diseases in which it occurs, and the existing diagnostic methods. At the same time, there is a divergence of views regarding the role of individual pathogenetic factors of gastroparesis and their relationship with clinical symptoms, as well as the effectiveness of drugs of various groups and other treatment methods.
Conclusion. The pathophysiological mechanisms of gastroparesis and the effectiveness of various treatment methods need further research.
About the Authors
A. A. Sheptulin
Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)
Arkadiy A. Sheptulin — Dr. Sci. (Med.), Prof., Chair of Internal Diseases Propedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, bld. 1
A. S. Trukhmanov
Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University)
Alexander S. Trukhmanov — Dr. Sci. (Med.), Prof., Chair of Internal Diseases Propedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, bld. 1
O. A. Storonova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Olga A. Storonova— Cand. Sci. (Med.), Physician, Department of Functional Diagnostics, Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, bld. 1
D. E. Rumyantseva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Diana E. Rumyantseva — Cand. Sci. (Med.), Physician, Department of Gastroenterology, Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, bld. 1
References
1. Schol J., Wauters L., Dickman R., Drug V., Mulak A., Serra J., et al., the ESNM Gastroparesis Consensus Group. United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis. United European Gastroenterol J. 2021;9:287–306. DOI: 10.1002/ueg2.12060
2. Camilleri M., Chedid V., Ford C.A., Haruma K., Horowitz M., Jones K.L., et al. Gastroparesis. Nat Rev Dis Primers. 2018;4(1):41. DOI: 10.1038/s41572-018-0038-z
3. Cangemi D.J., Lacy B.E. Gastroparesis and functional dyspepsia: different diseases or different ends of the spectrum? Curr Opin Gastroenterol. 2020;36(6):509–17. DOI: 10.1097/MOG.0000000000000677
4. Bharucha A.E. Epidemiology and natural history of gastroparesis Gastroenterol Clin North Am. 2015;44(1):9–19. DOI: 10.1016/j.gtc.2014.11.002
5. Hasler W.L., Wilson L.A., Parkman H.P., Koch K.L., Abell T.L., Nguyen L., et al. Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting. Neurogastroenterol Motil. 2013;25(5):427–38. DOI: 10.1111/nmo.12091
6. Barkin J.A., Czul F. Barkin J.S., Klimas N.G., Rey I.R., Moshiree B. Gastric enterovirus infection: A possible causative etiology of gastroparesis. Dig Dis Sci. 2016;61(8):2344–50. DOI: 10.1007/s10620-016-4227-x
7. Bekkelund M., Sangnes D.A., Hatlebakk J.G., Aabakken L. Pathophysiology of idiopathic gastroparesis and implications for therapy. Scand J Gastroenterol. 2019;54(1):8–17. DOI: 10.1080/00365521.2018.1558280
8. Karamanolis G., Tack J. Promotility medications — now and in the future. Dig Dis. 2006;24(3–4):297–307. DOI: 10.1159/000092883
9. Schey R., Saadi M., Midani D., Roberts A.C., Parupalli R., Parkman H.P. Domperidone to treat symptoms of gastroparesis: benefits and side effects from a large single-center cohort. Dig Dis Sci. 2016;61(12):3545–51. DOI: 10.1007/s10620-016-4272-5
10. Carbone F., Van den Houte K., Clevers E., Andrews C.N., Papthanasopoulos A., Holvoet L., et al. Prucalopride in gastroparesis: a randomized placebo-controlled crossover study. Am J Gastroenterol. 2019;114(8):1265–74. DOI: 10.14309/ajg.0000000000000304
11. Navas C.M., Patel N.K., Lacy B.E. Gastroparesis: medical and therapeutic advances. Dig Dis Sci. 2017;62(9):2231–40. DOI: 10.1007
12. Sullivan A., Temperley L., Ruban A. Pathophysiology, etiology and treatment of gastroparesis Dig Dis Sci. 2020;65(6):1615–31. DOI: 10.1007/s10620-020-06287-2
13. Usai-Satta P., Bellini M., Morelli O., Geri F., Lai M., Basotti G. Gastroparesis: New insights into an old disease. World J Gastroenterol. 2020;26(19):2333–48. DOI: 10.3748/wjg.v26.i19.2333
Review
For citations:
Sheptulin A.A., Trukhmanov A.S., Storonova O.A., Rumyantseva D.E. European Society for Neurogastroenterology and Motility Consensus on Gastroparesis: What Issues Remain Unresolved? Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(4):89-94. https://doi.org/10.22416/1382-4376-2022-32-4-89-94
Views:
844
Email this article 
