Preview

Russian Journal of Gastroenterology, Hepatology, Coloproctology

Advanced search

Prevalence of CagA-positive Helicobacter pylori strain and H. pylori-associated gastritis activity in Tuva schoolchildren of different age groups

https://doi.org/10.22416/1382-4376-2016-6-18-23

Abstract

Aim of investigation. To study the prevalence of CagApositive Helicobacter pylori (H. pylori) strain and to estimate activity of gastritis associated to this infection in schoolchildren presenting their dyspeptic complains in indigenous and extraterrestrial populations of Tuva republic. Material and methods. In 218 randomly selected schoolchildren (106 of them were extraterrestrial, 112 - native born) of overall 1064 children living in two settlements of the Tuva republic prevalence of CagA-positive H. pylori strain was studied. Inflammatory activity of the stomach body and antrum mucosa was studied in 59 Tuvinians and 72 Caucasians included in the study, according to predefined age groups (7-11 and 12-17 years). Results. Increase in the rate of CagA-seropositive children in local population was found to a large extent due to expense of junior children. Age-related increase in CagA-positive H pylori infection in specific ethnic group was insignificant. Antrum mucosa information in CagAseropositive children of extraterrestrial population was characterized by higher activity irrespective to age. That is not found in indigenous population. At CagAseropositive schoolchildren in both ethnic populations activity of corpus gastritis increased along with age. Conclusion. The received results demonstrate that development, course and progression of CagA-positive H. pylori associated gastritis is affected by genetic (ethnic) features of the host.

About the Authors

Tamara V. Polivanova
Federal State government-financed Institution «Scientific research institute of medical problems of the North»
Russian Federation


Vitaly A. Vshivkov
Federal State government-financed Institution «Scientific research institute of medical problems of the North»
Russian Federation


References

1. Аруин Л.И., Капуллер Л.Л., Исаков В.А. Морфологическая диагностика болезней желудка и кишечника. М.: Триада-Х; 1998. 272 с.

2. Гастроэнтерология: Национальное руководство / Под ред. В.Т. Ивашкина, Т.Л. Лапиной. М.: ГЭОТАРМедиа 2011; 480 с.

3. Писарева Л.Ф., Бояркина А.П., Ушакова И.В. Рак желудка в регионе Сибири и Дальнего Востока (19912005 гг.). Сибирский онкол журн 2009; 33(3):36-43.

4. Поливанова Т.В., Вшивков В.А., Фурцев В.И., Мищик В.Н. Возрастные особенности течения гастрита у школьников Тывы. Вопросы детской диетологии 2013; 11(3):39-44

5. Поливанова Т.В., Манчук В.Т., Вшивков В.А., Гончарова М.В. Распространенность инфекции Helicobacter pylori и ее ассоциация с клинико-морфологическими проявлениями гастродуоденальной патологии в этнических популяциях детей Республики Тывы. Педиатрия. Журнал им. Г.Н. Сперанского 2013; 92(6):135-40

6. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М.: МедиаСфера; 2003

7. Цуканов В.В., Баркалов С.В., Тонких Ю.Л. и др. Распространенность CagA-штаммов Helicobacter pylori и язвенная болезнь у населения Восточной Сибири. Тер арх 2007; 2:15-8

8. Шептулин А.А. Инфекция Helicobacter pylori и рак желудка: современное состояние проблемы. Рос журн гастроэнтерол гепатол колопроктол 2012; 2:77-82

9. Buzás G.M. Helicobacter pylori - 2010. Orv Hetil 2010; 151(49):2003-10.

10. Dixon M.F., Genta R.M., Yardley J.H. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? Helicobacter 1997; 2 (Suppl. 1):17-24.

11. Talley N.J., Stanghellini V., Heading R.C. et al. Functional gastrointestinal disorders. Gut 1999; 45(2):1137-42.

12. Yahiro K., Wada A., Nakayama M. et al. Proteintyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. J Biol Chem 2003; 278(21):19183-9.

13. Yamaoka Y., Reddy R., Graham D.Y. Helicobacter pylori virulence factor genotypes in children in the United States: clues about genotype and outcome relationships. J Clin Microbiol 2010; 48 (7):2550-1.


Review

For citations:


Polivanova T.V., Vshivkov V.A. Prevalence of CagA-positive Helicobacter pylori strain and H. pylori-associated gastritis activity in Tuva schoolchildren of different age groups. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(6):18-23. (In Russ.) https://doi.org/10.22416/1382-4376-2016-6-18-23

Views: 730


ISSN 1382-4376 (Print)
ISSN 2658-6673 (Online)