Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association

The aim of publication. To present modern concept on etiology and pathogenesis of the peptic ulcer (PUD) to general practitioners, to acquaint them with modern diagnostic methods and main treatment approaches of this disease. Summary. The PUD continues to remain one of the most widespread digestive disease. Despite a tendency to decrease of hospital admission rate of patients with uncomplicated PUD, increase in complicated forms of disease rate is noted that it is related mainly to the growing intake of non-steroidal anti-inflammatory drugs (NSAID). Helicobacter pylori infection has a leading role as PUD ethological factor. None H. pylori-associated gastroduodenal ulcers may be caused by NSAID intake or may develop within the other nosological entities (symptomatic stomach and duodenal ulcers). PUD diagnosis includes obligatory testing for H. pylori infection and carrying out eradication in the case of positive takes. At the present time the first line of antihelicobacter therapy includes standard triple clarithromycin and amoxicillin-based therapy, as well as quadrotherapy with bismuth drugs. The second line eradication therapy includes quadrotherapy with bismuth drugs and triple levofloxacin-based therapy. The third line therapy modes should be chosen after assessment of individual antibiotic sensitivity of H. pylori strains. The efficacy control of antihelicobacter treatment should be carried out not earlier than 4 weeks after the end of eradication. Conclusion. Strict conformance of diagnostic algorithm for this category of patients as well as the eradication therapy protocol allows to decrease considerably the risk of recurrence of PUD and its complications.

язва желудка, язва двенадцатиперстной кишки, инфекция Helicobacter pylori, эрадикация, ингибиторы протонной помпы

1. Shay H., Sun D. C.H. Etiology and pathology of gastric and duodenal ulcer // Bockus H. L. Gastroenterology. Philadelphia-London, 1968. Vol. 1. P. 420-65.

2. Spechler S. J. Peptic ulcer and its complications // Sleisenger & Fordtran’s Gastrointestinal and Liver Disease. Philadelphia-London-Toronto-Montreal-SydneyTokyo, 2002. Vol. 1. P. 747-81.

3. Göke Hrsg.B., Beglinger Ch. Gastroenterologie systematisch. Bremen-London-Boston, 2007, 2 Auflage. - S. 150-70.

4. Ramakrishnan K., Salinas R. C. Peptic ulcer disease. Am Family Physician 2007; 76: 1005-12.

5. Василенко В. Х., Гребенев А. Л., Шептулин А. А. Язвенная болезнь. М., Медицина, 1987.288 с.

6. Lau J. Y., Sung J., Hill C., et al. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion 2011; 84:102-13.

7. Здоровье населения России и деятельность учреждений здравоохранения в 1999 г. Статистические материалы МЗ РФ, 2000. [Health of the Russian population and activity of healthcare institutions in 1999. Statistical materials ministry of healthcare of the Russian Federation, 2000.]

8. Hawkey C. J., Wight N. J. Clinician’s manual on NSAIDS and gastrointestinal complications. London: Life Science Communications, 2001.56 р.

9. Ивашкин В. Т., Степанов Е. В., Баранская Е. К. и др. Взаимосвязь результатов лазерного 13С-уреазного дыхательного теста и морфологического состояния гастродуоденальной слизистой оболочки при различных H. pylori-ассоциированных заболеваниях. Рос журн гастроэнтерол гепатол колопроктол 2006; 16(3):77-85.

10. Malfertheiner P., Megraud F., O’Morain C., et al. Management of Helicobacter pylori infection the Maastricht V/ Florence Consensus report // Gut Online First, published on October 5, 2016 as 10.1136/ gutjnl-2016-312288.

11. Chung C. S., Chiang T. H., Lee V. C. A systemic approach for the diagnosis and treatment of idiopathic peptic ulcers. Korean J Intern Med 2015; 30: 559-70.

12. Бурков С. Г. Заболевания органов пищеварения у беременных. М.: КРОН-ПРЕСС, 1996, 217 с.

13. Бурков С. Г. Стратегия диагностики и медикаментозного лечения заболеваний органов пищеварения у беременных. Эксперим клин гастроэнтерол 2009; 7:72-8.

14. Cappell M. S. The fetal safety and clinical efficacy of gastrointestinal endoscopy during pregnancy. Gastroenterol Clin N Am 2003; 32:123-79.

15. Mahadevana U., Kaneb S. American Gastroenterological Association Institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology 2006; 13:283-311.

16. Burget D. W., Chiverton K. D., Hunt R. H. Is there an optimal degree of acid supression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterology 1990; 99: 345-51.

17. Moodlin I. M., Sachs G. Acid related diseases. Biology and treatment. D-Konstanz, 1998. P. 217-41.

18. Soll A. H. Peptic ulcer and its complications // Sleisenger & Fordtran’s Gastrointestinal and Liver Disease. Philadelphia-London-Toronto-Montreal-Sydney-Tokyo, 1998. Vol. 1. P. 620-78.

19. Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению инфекции Helicobacter pylori у взрослых. Рос журн гастроэнтерол гепатол колопроктол 2012; 22(1):87-9.

20. Nishizawa T., Nishizava Y., Yahagi N. Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: A systematic review and meta-analysis. J Gastroenterol Hepatol 2014; 29 (Suppl. 4):20-4.

21. Terano A., Arakawa T., Sugiyama T., et al. Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial. J Gastroenterol 2007; 42(8): 690-3.

22. Хакимова Д. Р. Часторецидивирующие язвы двенадцатиперстной кишки: факторы, способствующие формированию, и тактика лечения. Автореф. дис. … канд. мед. наук. М., 2004.

23. Евсеев М. А., Клишин И. М. Эффективность антисекреторной терапии ингибиторами протонной помпы при гастродуоденальных язвенных кровотечениях. Рос журн гастроэнтерол гепатол колопроктол 2010; 20(3):55-62.