Preview

User

Not a user? Register with this site Forgot your password?

Russian Journal of Gastroenterology, Hepatology, Coloproctology

Advanced search

Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution)

https://doi.org/10.22416/1382-4376-2024-954

Abstract

Aim: to discuss current views on the clinical significance, diagnostic opportunities, and therapeutic approaches in the treatment of small intestinal bacterial overgrowth (SIBO) as an important component in the gut microbiota function assessment, to assess the awareness of physicians and the opportunities in the diagnosis and treatment of this disease in patients in the Federal districts of the Russian Federation, as well as to present the proceedings of the Expert Council held on December 16, 2023 in Moscow.

Key points. SIBO is a common syndrome often associated with irritable bowel syndrome, liver cirrhosis, asthma, and congestive heart failure, being also a predictor of early death in the elderly. Today, in many regions of the Russian Federation, there are limitations for instrumental diagnosis of this disease — lack of awareness among doctors, unavailability of gas analyzers for diagnosing SIBO, lack of information about the need to diagnose SIBO in the standards of compulsory health insurance. Rifaximin is the first-line treatment due to the highest therapeutic efficacy. One of the ways to increase the efficacy of SIBO treatment is to include strain-specific probiotics in the treatment regimen. Saccharomyces boulardii CNCM I-745 is thought to be the most studied, promising probiotic. The review also presents statistical data on the issues in the diagnosis and treatment of SIBO in the regions of the Russian Federation.

Conclusion. Optimization of approaches to the diagnosis and treatment of SIBO, the development of domestic gas analyzers, increasing the awareness of physicians in all regions of the Russian Federation, as well as the development and optimization of clinical recommendations appear to be necessary measures to increase the effectiveness of medical care, the duration and quality of life of the Russian population. These goals can be achieved within the framework of Federal programs under the supervision of specialized reference centers of the Ministry of Health of the Russian Federation.

About the Authors

V. T. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Vladimir T. Ivashkin — Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine, Director of V. Kh. Vasilenko Clinic of Propaedeutics of Internal Disease, Gastroenterology and Hepatology

119991, Moscow, Pogodinskaya str., 1, build. 1


V. V. Fomin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Viktor V. Fomin — Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Vice-Rector for Clinical Activities and Additional Professional Education, Head of the Department of Faculty Therapy No. 1 of the N.V. Sklifosovsky Institute of Clinical Medicine; Chief Specialist in General Medical of the Ministry of Health of the Russian Federation

119048, Moscow, Trubetskaya str., 8, build. 2


O. N. Tkacheva
N.I. Pirogov Russian National Research Medical University
Russian Federation

Olga N. Tkacheva — Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Director of the Separate Subdivision “Russian Research and Clinical Center for Gerontology”

129226, Moscow, Pervaya Leonova str., 16


O. S. Medvedev
M.V. Lomonosov Moscow State University; National Medical Research Center of Cardiology names after Academician E.I. Chazov
Russian Federation

Oleg S. Medvedev — Dr. Sci. (Med.), Professor, Head of the Department of Pharmacology, Faculty of Fundamental Medicine; Head of the Laboratory of Experimental Pharmacology

119991, Moscow, Lomonosovskiy ave., 27, build. 1


E. A. Poluektova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena A. Poluektova — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine, Gastroenterologist of the Department of Chronic Intestinal and Pancreatic Diseases of V.Kh. Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology

119991, Moscow, Pogodinskaya str., 1, build. 1


D. I. Abdulganieva
Kazan State Medical University
Russian Federation

Diana I. Abdulganieva — Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy; Chief Internal Medicine Specialist of the Republic of Tatarstan

420012, Kazan, Butlerova str., 49


S. R. Abdulkhakov
Kazan State Medical University; Kazan (Volga Region) Federal University
Russian Federation

Sayar R. Abdulkhakov — Cand. Sci. (Med.), Head of the Department of Internal Diseases, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Associate Professor of the Department of Outpatient Therapy and General Medical Practice, Kazan State Medical University

420012, Kazan, Kremlevskaya str., 18


O. P. Alexeeva
Privolzhsky Research Medical University
Russian Federation

Olga P. Alexeeva — Dr. Sci. (Med.), Professor of the Department of Hospital Therapy and General Medical Practice named after V.G. Vogralik; Chief Gastroenterologist of the Volga Federal district

603005, Nizhny Novgorod, Minina i Pozharskogo sq., 10/1


S. A. Alekseenko
Far-Eastern State Medical University
Russian Federation

Sergei A. Alekseenko — Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy; Chief Gastroenterologist of the Far Eastern Federal district

680000, Khabarovsk, Muravyova-Amurskogo str., 35


D. N. Andreev
Russian University of Medicine
Russian Federation

Dmitry N. Andreev — Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology

127473, Moscow, Delegatskaya str., 20, build. 1


A. Yu. Baranovsky
Saint Petersburg State University
Russian Federation

Andrey Yu. Baranovsky — Dr. Sci. (Med.), Professor, Head of the Department of Gastroenterology, Hepatology and Nutritional Medicine; Chief Gastroenterologist of the North-Western Federal district

199226, St. Petersburg, Korablestroiteley str., 20, build. 1


M. S. Zharkova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Maria S. Zharkova — Cand. Sci. (Med.), Head of the Department of Hepatology, V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1


O. Yu. Zolnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Oxana Yu. Zolnikova — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine; Chief Gastroenterologist of the Central Federal district

119435, Moscow, Pogodinskaya str., 1, build. 1


K. V. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Konstantin V. Ivashkin — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine

119435, Moscow, Pogodinskaya str., 1, build. 1


I. L. Kliaritskaia
V.I. Vernadsky Crimea Federal University
Russian Federation

Irina L. Kliaritskaia — Dr. Sci. (Med.), Professor, Head of the Department of Internal Medicine, Gastroenterology, Cardiology and General Medical Practice (Family Medicine), S.I. Georgievsky Medical Academy

295017, Simferopol, Lenina blvd., 5/7


N. V. Korochanskaya
Kuban State Medical University
Russian Federation

Natalia V. Korochanskaya — Dr. Sci. (Med.), Professor at the Department of Surgery No. 3, Faculty of Advanced Training and Postgraduate Studies; Chief Gastroenterologist of the Krasnodar Territory

350063, Krasnodar, Mitrofana Sedina str., 4


S. N. Mammaev
Dagestan State Medical University
Russian Federation

Suleiman N. Mammaev — Dr. Sci. (Med.), Professor of the Department of Hospital Therapy No. 1; Chief Gastroenterologist of the North Caucasian Federal district

367000, Makhachkala, Lenina sq., 1


R. V. Maslennikov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Roman V. Maslennikov — Dr. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine

119435, Moscow, Pogodinskaya str., 1, build. 1


R. G. Myazin
Volgograd State Medical University
Russian Federation

Roman G. Myazin — Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine

400131, Volgograd, Pavshikh Bortsov sq., 1


M. V. Perekalina
Stavropol Territorial Clinical Hospital
Russian Federation

Marina V. Perekalina — Cand. Sci. (Med.), Head of the Department of Gastroenterology; Chief Gastroenterologist of the Stavropol Territory

355002, Stavropol, Lermontova str., 208


A. V. Povtoreyko
Pskov Regional Infectious Disease Hospital
Russian Federation

Anastasia V. Povtoreyko — Chief Physician; Chief Pulmonologist of the Pskov Region

180016, Pskov, Mayora Dostavalova str., 14


A. I. Ulyanin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anatoly I. Ulyanin — Gastroenterologist of the Department of Chronic Intestinal and Pancreatic Diseases, V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119991, Moscow, Pogodinskaya str., 1, build. 1


M. V. Fadeeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Maria V. Fadeeva — Cand. Sci. (Med.), Cardiologist of the Department of Cardiology, V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119991, Moscow, Pogodinskaya str., 1, build. 1


I. B. Khlynov
Ural State Medical University
Russian Federation

Igor B. Khlynov — Dr. Sci. (Med.), Associate Professor of the Department of Intermediate Therapy and Geriatrics; Chief Gastroenterologist of the Ural Federal district

620028, Yekaterinburg, Repina str., 3


V. V. Tsukanov
Scientific Research Institute of Medical Problems of the North, Federal Research Center “Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences”
Russian Federation

Vladislav V. Tsukanov — Dr. Sci. (Med.), Professor, Head of the Clinical Department of Adult and Infant Digestive Pathology, Scientific Research Institute of Medical Problems of the North; Chief Gastroenterologist of the Siberian Federal district

660022, Krasnoyarsk, Partizana Zheleznyaka str., 3g


O. S. Shifrin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Oleg S. Shifrin — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine, Head of the Department of Chronic Intestinal and Pancreatic Diseases of the V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1


References

1. Rezaie A., Buresi M., Lembo A., Lin H., McCallum R., Rao S., et al. Hydrogen and methane-based breath testing in gastrointestinal disorders: The North American consensus. Am J Gastroenterol. 2017;112(5):775–84. DOI: 10.1038/ajg.2017.46

2. Ivashkin V.T., Maev I.V., Abdulganieva D.I., Alekseeva O.P., Alekseenko S.A., Zolnikova O.Yu., et al. Practical Recommendation of the Scientific Community for Human Microbiome Research (CHMR) and the Russian Gastroenterological Association (RGA) on small intestinal bacterial overgrowth in adults. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(3):68–85. (In Russ.). DOI: 10.22416/1382-4376-2022-32-3-68-85

3. Efremova I., Maslennikov R., Poluektova E., Vasilieva E., Zharikov Y., Suslov A., et al. Epidemiology of small intestinal bacterial overgrowth. World J Gastroenterol. 2023;29(22):3400–21. DOI: 10.3748/wjg.v29.i22.3400

4. Leite G., Morales W., Weitsman S., Celly S., Parodi G., Mathur R., et al. The duodenal microbiome is altered in small intestinal bacterial overgrowth. PLoS One. 2020;15(7):e0234906. DOI: 10.1371/journal.pone.0234906

5. Takakura W., Pimentel M. Small intestinal bacterial overgrowth and irritable bowel syndrome — An update. Front Psychiatry. 2020;11:664. DOI: 10.3389/fpsyt.2020.00664

6. Sachdev A.H., Pimentel M. Gastrointestinal bacterial overgrowth: Pathogenesis and clinical significance. Ther Adv Chronic Dis. 2013;4(5):223–31. DOI: 10.1177/2040622313496126

7. Pyleris E., Tzivras D., Barbatzas C., Giamarellos-Bourboulis E.J., Koussoulas V., Pimentel M. The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: Relationship with irritable bowel syndrome. Dig Dis Sci. 2012:57(5):1321–9. DOI: 10.1007/s10620-012-2033-7

8. Li J., Zhang R., Ma J., Tang S., Li Y., Li Y., et al. Mucosa-associated microbial profile is altered in small intestinal bacterial overgrowth. Front Microbiol. 2021;12:710940. DOI: 10.3389/fmicb.2021.710940

9. Benoit S.L., Maier R.J., Sawers R.G., Greening C. Molecular hydrogen metabolism: A widespread trait of pathogenic bacteria and protists. Microbiol Mol Biol Rev. 2020;84(1):e00092-19. DOI: 10.1128/MMBR.00092-19

10. Levitt M.D. Production and excretion of hydrogen gas in man. N Engl J Med. 1969;281(3):122–7. DOI: 10.1056/NEJM196907172810303

11. Kalantar-Zadeh K., Berean K.J., Burgell R.E., Muir J.G., Gibson P.R. Intestinal gases: Influence on gut disorders and the role of dietary manipulations. Nat Rev Gastroenterol Hepatol. 2019;16(12);733–47. DOI: 10.1038/s41575-019-0193-z

12. Min J., Yang Y., Wu Z., Gao W. Robotics in the gut. Adv Ther. 2020;3(4):1900125. DOI: 10.1002/adtp.201900125

13. Shimouchi A., Nose K., Shirai M., Kondo T. Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water. Adv Exp Med Biol. 2012;737:245–50. DOI: 10.1007/978-1-4614-1566-4_36

14. Mahnert A., Blohs M., Pausan M.R., Moissl-Eichinger C. The human archaeome: Methodological pitfalls and knowledge gaps. Emerg Top Life Sci. 2018;2(4):469–82. DOI: 10.1042/ETLS20180037

15. Ruaud A., Esquivel-Elizondo S., de la Cuesta-Zuluaga J., Waters J.L., Angenent L.T., Youngblut N.D., et al. Syntrophy via interspecies H 2 transfer between Christensenella and Methanobrevibacter underlies their global cooccurrence in the human gut. mBio. 2020;11(1):e03235–19. DOI: 10.1128/mBio.03235-19

16. Ivashkin V.T., Medvedev O.S., Poluektova E.A., Kudryavtseva A.V., Bakhtogarimov I.R., Karchevskaya A.E. Direct and indirect methods for studying human gut microbiota. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(2):19–34. (In Russ.). DOI: 10.22416/1382-4376-2022-32-2-19-34

17. Gatta L., Scarpignato C. Systematic review with meta-analysis: Rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth. Aliment Pharmacol Ther. 2017;45(5):604–16. DOI: 10.1111/apt.13928

18. Ivashkin V.T., Maev I.V., Abdulganieva D.I., Alekseenko S.A., Gorelov A.V., Zakharova I.N., et al. Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on use of probiotics, prebiotics, synbiotics and functional foods in treatment and prevention of gastroenterological diseases in children and adults. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(2):65–91. (In Russ.). DOI: 10.22416/1382-4376-2021-31-2-65-91

19. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015;42(7):793–801. DOI: 10.1111/apt.13344

20. Goldenberg J.Z., Yap C., Lytvyn L., Lo C.K., Beardsley J., Mertz D., et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017;12(12):CD006095. DOI: 10.1002/14651858.CD006095.pub4

21. García-Collinot G., Madrigal-Santillán E.O., Martínez-Bencomo M.A., Carranza-Muleiro R.A., Jara L.J., Vera-Lastra O. et al. Effectiveness of Saccharomyces boulardii and metronidazole for small intestinal bacterial overgrowth in systemic sclerosis. Dig Dis Sci. 2020;65(4):1134–43. DOI: 10.1007/s10620-019-05830-0

22. Onana Ndong P., Boutallaka H., Marine-Barjoan E., Ouizeman D., Mroue R., Anty R., et al. Prevalence of small intestinal bacterial overgrowth in irritable bowel syndrome (IBS): Correlating H 2 or CH 4 production with severity of IBS. JGH Open. 2023;7(4):311–20. DOI: 10.1002/jgh3.12899

23. Tang H.Y., Jiang A.J., Wang X.Y., Wang H., Guan Y.Y., Li F., et al. Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: A narrative review. Ann Transl Med. 2021;9(14):1187. DOI: 10.21037/atm-21-2779

24. Kossewska J., Bierlit K., Trajkovski V. Personality, anxiety, and stress in patients with small intestine bacterial overgrowth syndrome. The Polish Preliminary Study. Int J Environ Res Publ Health. 2022;20(1):93. DOI: 10.3390/ijerph20010093

25. Haq S., Grondin J.A., Khan W.I. Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation. FASEB J. 2021;35(10):e21888. DOI: 10.1096/fj.202100702R

26. Vincent A.D., Wang X.Y., Parsons S.P., Khan W.I., Huizinga J.D. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. Am J Physiol Gastrointest Liver Physiol. 2018;315(5):G896–907. DOI: 10.1152/ajpgi.00237.2017

27. Cao H., Liu X., An Y., Zhou G., Liu Y., Xu M., et al. Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Sci Rep. 2017;7(1):10322. DOI: 10.1038/s41598-017-10835-8

28. Guillemin G.J. Quinolinic acid, the inescapable neurotoxin. FEBS J. 2012;279(8):1356–65. DOI: 10.1111/j.1742-4658.2012.08485.x

29. Zakrocka I., Targowska-Duda K.M., Wnorowski A., Kocki T., Jóźwiak K., Turski W.A. Influence of cyclooxygenase-2 inhibitors on kynurenic acid production in rat brain in vitro. Neurotox Res. 2019;35(1);244–54. DOI: 10.1007/s12640-018-9952-9

30. Chojnacki C., Konrad P., Błońska A., Medrek-Socha M., Przybylowska-Sygut K., Chojnacki J., et al. Altered tryptophan metabolism on the kynurenine pathway in depressive patients with small intestinal bacterial overgrowth. Nutrients. 2022;14(15):3217. DOI: 10.3390/nu14153217

31. Chojnacki C., Błońska A., Konrad P., Chojnacki M., Podogrocki M., Poplawski T. Changes in tryptophan metabolism on serotonin and kynurenine pathways in patients with irritable bowel syndrome. Nutrients. 2023;15(5):1262. DOI: 10.3390/nu15051262

32. Kovaleva A., Poluektova E., Maslennikov R., Karchevskaya A., Shifrin O., Kiryukhin A., et al. Effect of rebamipide on the intestinal barrier, gut microbiota structure and function, and symptom severity associated with irritable bowel syndrome and functional dyspepsia overlap: A randomized controlled trial. J Clin Med. 2023;12(18):6064. DOI: 10.3390/jcm12186064

33. Alam M.J., Chen J.D.Z. Non-invasive neuromodulation: An emerging intervention for visceral pain in gastrointestinal disorders. Bioelectron Med. 2023;9(1):27. DOI: 10.1186/s42234-023-00130-5

34. Ivashkin V.T., Maev I.V., Shelygin Yu.A., Baranskaya E.K., Belous S.S., Belousova E.A., et al. Diagnosis and treatment of irritable bowel syndrome: Clinical recommendations of the Russian Gastroenterological Association and Association of Coloproctologists of Russia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(5):74–95. (In Russ.). DOI: 10.22416/1382-4376-2021-31-5-74-95

35. Yu X., Li Y., Xiang F., Feng J. Correlation between small intestinal bacterial overgrowth and irritable bowel syndrome and the prognosis of treatment. Ann Palliat Med. 2021;10(3):3364–70. DOI: 10.21037/apm-21-427

36. Volk M.L., Tocco R.S., Bazick J., Rakoski M.O., Lok A.S. Hospital readmissions among patients with decompensated cirrhosis. Am J Gastroenterol. 2012;107(2):247–52. DOI: 10.1038/ajg.2011.314

37. Maslennikov R., Pavlov C., Ivashkin V. Small intestinal bacterial overgrowth in cirrhosis: Systematic review and meta-analysis. Hepatol Int. 2018;12(6):567–76. DOI: 10.1007/s12072-018-9898-2

38. Zharkova M.S., Mayevskaya M.V., Ivashkin V.T. The effect of bacterial overgrowth syndrome and bacterial translocation on the course of liver cirrhosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2012;22(5):56–63. (In Russ.).

39. Efremova I., Maslennikov R., Alieva A., Poluektova E., Ivashkin V. Small intestinal bacterial overgrowth is associated with poor prognosis in cirrhosis. Microorganisms. 2023;11(4):1017. DOI: 10.3390/microorganisms11041017

40. Bernardi M., Moreau R., Angeli P., Schnabl B., Arroyo V. Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis. J Hepatol. 2015;63(5):1272–84. DOI: 10.1016/j.jhep.2015.07.004

41. Arroyo V., García-Martinez R., Salvatella X. Human serum albumin, systemic inflammation, and cirrhosis. J Hepatol. 2014;61(2):396–407. DOI: 10.1016/j.jhep.2014.04.012

42. Maslennikov R., Pavlov C., Ivashkin V. Is small intestinal bacterial overgrowth a cause of hyperdynamic circulation in cirrhosis? Turk J gastroenterol. 2019;30(11):964–75. DOI: 10.5152/tjg.2019.18551

43. Cui B., Lin L., Wang B., Liu W., Sun C. Therapeutic potential of Saccharomyces boulardii in liver diseases: From passive bystander to protective performer? Pharmacol Res. 2022:175:106022. DOI: 10.1016/j.phrs.2021.106022

44. Potskhverashvili N.D., Zolnikova O.Yu., Kokina N.I., Dzhakhaya N.L., Sedova A.V., Bueverova E.L., et al. Small bowel bacterial overgrowth syndrome in patients with bronchial asthma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2018;28(4):47–54. (In Russ.). DOI: 10.22416/1382-4376-2018-28-4-47-54

45. Zolnikova O.Yu., Potskhverashvili N.D., Kudryavtseva A.V., Krasnov G.S., Guvatova Z.G., Trukhmanov A.S., et al. Changes in gut microbiota with bronchial asthma. Terapevticheskii arkhiv. 2020;92(3):56–60. (In Russ.). DOI: 10.26442/00403660.2020.03.000554

46. Zolnikova O.Yu., Potskhverashvili N.D., Kokina N.I., Trukhmanov A.S., Ivashkin V.T. Intestinal short-chain fatty acids in patients with bronchial asthma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(2):53–9. (In Russ.). DOI: 10.22416/1382-4376-2019-29-2-53-59

47. Enaud R., Prevel R., Ciarlo E., Beaufils F., Wieërs G., Guery B., et al. The gut-lung axis in health and respiratory diseases: A place for inter-organ and inter-kingdom crosstalks. Front Cell Infect Microbiol. 2020;10:9. DOI: 10.3389/fcimb.2020.00009

48. Ivashkin V., Zolnikova O., Potskherashvili N., Trukhmanov A., Kokina N., Dzhakhaya N. A correction of a gut microflora composition for the allergic bronchial asthma complex therapy. Italian Journal of Medicine. 2018;12(4):260–4. DOI: 10.4081/itjm.2018.1040

49. Zolnikova O.Yu., Potskherashvili N.D., Kokina N.I., Trukhmanov A.S., Ivashkin V.T. Effect of small intestine bacterial overgrowth syndrome on the course of bronchial asthma. Molekulyarnaya Meditsina (Molecular medicine). 2020;18(1):48–52. (In Russ.). DOI: 10.29296/24999490-2020-01-08

50. Ozimek M., Ivashkin V., Zolnikova O., Potskherashvili N., Ivashkin K., Dzhakhaya N., et al. A metabolic activity recovery of the intestinal microbiota in the patients with bronchial asthma. Pulm Med. 2022;2022:9902438. DOI: 10.1155/2022/9902438

51. Fadeeva M.V., Skhirtladze M.R., Ivashkin V.T. Small intestinal bacterial overgrowth syndrome as a risk factor for ventricular tachycardia in chronic heart failure with left ventricular systolic dysfunction. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(3):38–48. (In Russ.). DOI: 10.22416/1382-4376-2019-29-3-38-48

52. Mollar A., Villanueva M.P., Núñez E., Carratal Á., Mora F., Bayés-Genís A., et al. Hydrogenand methane-based breath testing and outcomes in patients with heart failure. J Card Fail. 2019;25(5):319–27. DOI: 10.1016/j.cardfail.2018.10.004

53. Song Y., Liu Y., Qi B., Cui X., Dong X., Wang Y., et al. Association of small intestinal bacterial overgrowth with heart failure and its prediction for short-term outcomes. J Am Heart Assoc. 2021;10(7):e015292. DOI: 10.1161/JAHA.119.015292

54. Matsiras D., Bezati S., Ventoulis I., Verras C., Parissis J., Polyzogopoulou E. Gut failure: A review of the pathophysiology and therapeutic potentials in the gutheart axis. J Clin Med. 2023;12(7):2567. DOI: 10.3390/jcm12072567

55. Sandek A., Bjarnason I., Volk H.D., Crane R., Meddings J.B., Niebauer J., et al. Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. Int J Cardiol. 2012;157(1):80–5. DOI: 10.1016/j.ijcard.2010.12.016

56. Bozkurt B., Mann D.L., Deswal A. Biomarkers of inflammation in heart failure. Heart Fail Rev. 2010;15(4):331–41. DOI: 10.1007/s10741-009-9140-3

57. Mezzasoma L., Antognelli C., Talesa V.N. Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1 ß release by inhibiting NF-kB, NLRP3 inflammasome and cas-pase-1 activation in THP-1 cells. Immunol Res. 2016;64(1):303–12. DOI: 10.1007/s12026-015-8751-0

58. Chamarthi B., Williams G.H., Ricchiuti V., Srikumar N., Hopkins P.N., Luther J.M., et al. Inflammation and hypertension: The interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans. Am J Hypertens. 2011;24(10):1143–8. DOI: 10.1038/ajh.2011.113

59. Costanza A.C., Moscavitch S.D., Faria Neto H.C., Mesquita E.T. Probiotic therapy with Saccharomyces boulardii for heart failure patients: A randomized, double-blind, placebo-controlled pilot trial. Int J Cardiol. 2015;179: 348–50. DOI: 10.1016/j.ijcard.2014.11.034

60. Tkacheva O.N., Tutelyan V.A., Shestopalov A.E., Kotovskaya Yu.V., Starodubova A.V., Pogozheva А.V., et al. Nutritional insufficiency (malnutrition) in older adults. Clinical recommendations. Russian Journal of Geriatric Medicine. 2021;(1):15–34. (In Russ.). DOI: 10.37586/2686-8636-1-2021-15-34

61. Kaiser M.J., Bauer J.M., Ramsch C., Uter W., Guigoz Y., Cederholm T., et al. Validation of the Mini Nutritional Assessment short-form (MNA-SF): A practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13(9):782–8. DOI: 10.1007/s12603-009-0214-7

62. Tkacheva O.N., Runikhina N.K., Ostapenko V.S., Sharashkina N.V., Mkhitaryan E.A., Onuchina J.S., et al. Prevalence of geriatric syndromes among people aged 65 years and older at four community clinics in Moscow. Clin Interv Aging. 2018;13:251–9. DOI: 10.2147/CIA.S153389

63. Gurina N.A., Frolova E.V., Degrys Y. The health status of the elderly in a St. Petersburg district: Results of Crystal project. Advances in Gerontology. 2011;24(1):114–20. (In Russ.).


Supplementary files

Review

For citations:

Ivashkin V.T., Fomin V.V., Tkacheva O.N., Medvedev O.S., Poluektova E.A., Abdulganieva D.I., Abdulkhakov S.R., Alexeeva O.P., Alekseenko S.A., Andreev D.N., Baranovsky A.Yu., Zharkova M.S., Zolnikova O.Yu., Ivashkin K.V., Kliaritskaia I.L., Korochanskaya N.V., Mammaev S.N., Maslennikov R.V., Myazin R.G., Perekalina M.V., Povtoreyko A.V., Ulyanin A.I., Fadeeva M.V., Khlynov I.B., Tsukanov V.V., Shifrin O.S. Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(2):14-34. https://doi.org/10.22416/1382-4376-2024-954

Views: 3951


ISSN 1382-4376 (Print)
ISSN 2658-6673 (Online)

Tatiana L. Lapina - MD, PhD, associate professor, Department of Internal Diseases Propedeutics,
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
119146,  Moscow, PO box 31
e-mail: editorial@gastro-j.ru, tatlapina@gmail.com
tel.: +79031926919

Processing of personal data
supported by NEICON (Elpub lab)