Viral hepatitis B epidemiology in Sakha republic (Yakutia)
Abstract
Aim of investigation. To estimate epidemiologic state on viral hepatitis B in Sakha republic (Yakutia).
Material and methods. Data of the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) for Sakha republic (report form #1) and results of enzyme-linked immunoassay (EIA) for viral hepatitis markers (HBsAg, a-HBcor IgG, a-HDV, a-HCV) in population of 17 areas of republic were utilized.
Results. In investigated region morbidity due to both acute and chronic forms of hepatitis B has a tendency to decrease. According to EIA results the prevalence of hepatitis B virus infection markers in population corresponds to criteria of intermediate intensity and for hepatitis D virus — to high intensity.
Conclusions. Morbidity due to hepatitis is significantly higher: i.e. 5 times over that for the Russian Federation in general.
About the Authors
S. I. SemenovRussian Federation
Semenov Sergey I — MD, PhD, leading research associate
677010, Yakutsk, 4 km of Sergelyahskoe highway, building S-2
R. G. Savvin
Russian Federation
S. G. Nikitina
Russian Federation
S. S. Maksimova
Russian Federation
V. G. Krivoshapkin
Russian Federation
S. S. Sleptsova
Russian Federation
References
1. Tatochenko V.K., Ozeretskovsky N.A., Fedorov A.N. Immunological prophylaxis - 2009: Manual, 9 ed., add. М., 2009.173 p.
2. Yashina T.L., Favorov M.O., Shahgildyan I.V. et al. Spread of hepatitis B and delta markers in regions with contrast morbidity levels. Vopr virusol 1992; 4: 194-6.
3. Shlyahtenko L.I., Nechayev V.V., Vysotsky V.S. Mechanisms and routes of conduction of hepatitis virus B (theoretical study). In: Viral hepatites A and B. L., 1988. P. 18-23.
4. Kuzin S.N., Ikoev V.N., Shahgildyan I.V. et al., Principles of perinatal hepatitis B virus infection in territories, contrast for HBsAg and HBeAg carriage level. Vopr virusol 1990; 4:304-6.
5. Aleynik M.D., Ryabikova T.F., Bakayeva I.A., Makarevich I.K. Epidemiologic laws of spread of hepatitis B and approaches for improvement of antiepidemic actions. In: Viral hepatites. Gorky, 1988. Р. 5-9.
6. Shahgildyan I.V., Onishchenko G.G., Khukhlovich P.A. et al. Study results and unresolved questions of epidemiology and prophylaxis of parenteral viral hepatites in Russia. ZhMEI 1994; 5:26-32.
7. Desmet V., Gerber M., Hoofnagle J.H., et al. Классификация хронического гепатита: диагностика, определение степени тяжести и стадии течения. Рос журн гастроэнтерол гепатол колопроктол 1995; 15(2):38-45.
8. Kuzin S.N. Comparative epidemiologic features of hepatites with parenteral route of transmission in Russia and selected CIS countries. Author's abstract. PhD degree thesis. М., 1998. 242 p.
9. Sadikova N.V., Varlamova I.A., Korshunova G.S. et al., Estimation of role of sexual and narcotic-related routes of transmission of hepatites B and C viruses. In: Viral hepatites: - issues of epidemiology, diagnostics, treatment and prophylaxis. 2005. P. 302-3.
10. Yamamoto K., Horikita M., Tsuda F., et al. Naturally occurring escape mutants of hepatitis В virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis В surface antigen. J Virol 1994; 68: 2671–6.
11. Carman W.F., Zanetti A.R., Karayiannis P., et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990; 336:325-9.
12. Weber B. The diagnostic and clinical impact of the genetic variability of the S (surface) gene of hepatitis B virus. J Lab Med 2004; 28(1):56-69.
13. Weber B., Melchior W., Gehrke R., et al. Hepatitis B virus markers in anti-HBc only positive individuals. J Med Virol 2001; 64:312-9.
14. Seddigh-Tonekaboni S., Waters J.A., Jeffers S., et al. Effect of variation in the common’ a’determinant on the antigenicity of hepatitis B surface antigen. J Med Virol 2000; 60:113-21.
15. Netesova I.G., Bazhenov A.I., Kuptsova V.E. et al. HBsAg subtypes in blood samples of donors of Russia Central federal district (CFD). In: Viral hepatitis B - diagnostics, treatment and prophylaxis (to the 40-anniversary of HBsAg discovery). М., 2004; 128-9.
16. Shahgildyan I.V., Mikhaylov M.I., Onishchenko G.G. Parenteral viral hepatites (epidemiology, diagnostics, prophylaxis). М., 2003. 383 p.
17. Kuzin S.N. Comparative epidemiologic features of hepatites with parenteral route of transmission in Russia and other CIS countries: Author's abstract. PhD degree thesis. М., 1998. 52 p.
18. Semenov S.I. Epidemiologic features and the clinical features of viral hepatites B, C and delta in Republic Sakha (Yakutia): Author's abstract. PhD degree thesis. М., 2007. 48 p.
Review
For citations:
Semenov S.I., Savvin R.G., Nikitina S.G., Maksimova S.S., Krivoshapkin V.G., Sleptsova S.S. Viral hepatitis B epidemiology in Sakha republic (Yakutia). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(4):53-58. (In Russ.)