The intestinal microbiome as a separate organ
Abstract
The aim of review. To discuss functions of intestinal bacteria as a part of the «host» body basing on the present-time publications, to consider interaction of bacteria with macroorganism, which reminds intercellular cooperation by its nature.
Key points. Intestinal microbiome encompasses about 1014 microorganisms, over 99% of microbiome genetic material belong to bacteria. In healthy people three basic enterotypes (according to the type of dominating species) are defined. The pattern of small intestine microflora is studied much poorly, than that of the large intestine. Due to difference in sampling methods it is difficult to draw clear-cut conclusions on microflora role in pathogenesis for scientific investigations. Analysis of sequential cloning of 16S ribosomal RNA possesses the highest information value of all up-to-date methods. Interaction of bacteria with the «host» reminds cooperation of usual cells and can be carried out due to receptor binding, paracrine and humoral pathways, as well as due to phagocytosis and endocytosis. Microbes produce hormone-like substances, analogues of growth factors and neurotransmitters that determine two-way interaction of microflora with the central nervous system and its active metabolic role. The microbiome dynamically reacts to environmental changes, including stress. Studing of intestinal microbiome impact in development of visceral hypersensitivity, regulation of intestinal motility and sensitivity is quite promising trend.
About the Author
Yu. O. Shulpekova
State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Shulpekova Yulia O – lecturer, chair of internal diseases propedeutics, medical faculty
119991, Moscow, Pogodinskaya street, 1, bld 1
References
1. Ивашкин В.Т., Шептулин А.А., Склянская О.А. Синдром диареи. М.: ГЭОТАР-Медиа 2002:58-63.
2. Кучумова С.Ю., Полуэктова Е.А., Шептулин А.А., Ивашкин В.Т. Физиологическое значение кишечной микрофлоры. Рос журн гастроэнтерол гепатол колопроктол 2011; 21(5); 5-9.
3. Полуэктова Е.А., Кучумова С.Ю., Шифрин О.С., Шептулин А.А., Ивашкин В.Т. Патогенетическое значение изменений кишечной микрофлоры у больных с синдромом раздраженного кишечника и возможности их коррекции. Рос журн гастроэнтерол гепатол колопроктол 2014; 24(3):89-97.
4. Полуэктова Е.А., Ляшенко О.С., Шифрин О.С., Шептулин А.А., Ивашкин В.Т. Современные методы изучения микрофлоры желудочно-кишечного тракта человека. Рос журн гастроэнтерол гепатол колопроктол 2014; 24(5):85-91.
5. Agrawal A., Houghton L.A., Morris J., Reilly B., Guyonnet D., Goupil Feuillerat N., et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2009; 29(1):104-14.
6. Bercik P., Denou E., Collins J., Jackson W., Lu J., Jury J., et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 2011; 141(2):599-609.
7. Bercik P., Park A.J., Sinclair D. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil 2011; 23(12):1132-9.
8. Cryan J.F., Dinan T.G. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012; 13(10):701-12.
9. Diaz Heijtz R., Wang S., Anuar F. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci U S A 2011; 108(7):3047-52.
10. Dore О., Simren M., Buttle L., Guarner F. Hot topics in gut microbiota. United European Gastroenterol J 2013; 1(5):311-8.
11. Everard A., Lazarevic V., Derrien M, Girard M., Muccioli G.G., Neyrinck A.M., et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 2011; 60(11):2775-86.
12. Guyonnet D., Chassany O., Ducrotte P., Picard C., Mouret M., Mercier C.H., Matuchansky C. Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. Aliment Pharmacol Ther 2007; 26(3):475-86.
13. Konya T., Koster B., Maughan H., Escobar M., Azad M.B., Guttman D.S., et al. Associations between bacterial communities of house dust and infant gut. Environ Res 2014; 131:25-30.
14. Ley R.E., Bäckhed F., Turnbaugh P., Lozupone C.A., Knight R.D., Gordon J.I. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005; 102(31):11070-5.
15. Mayer E.A., Tillisch K. The Brain-gut axis in abdominal pain syndromes. Ann Rev Med 2011; 62:381-96.
16. Mazmanian S.K., Round J.L., Kasper D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008; 453:620-5.
17. Meance S., Cayuela C., Raimondi A., Turchet P., Lucas C., Antoineet J.-M. Recent advance in the use of functional foods: Effect of the commercial fermented milk with Bifidobacterium animalis strain DN-173 010 and yogurt strains on gut transit time in the elderly. Microb Ecology Health Dis 2003; 15:15-22.
18. Olivares M., Albrecht S., De Palma G., Ferrer M.D., Castillejo G., Schols H.A., Sanz Y. Human milk composition differs in healthy mothers and mothers with celiac disease. Eur J Nutr 2014. Интернет-страница http:// www.ncbi.nlm.nih.gov/pubmed
19. Rhee S.H., Pothoulakis C., Mayer E.A. Principles and clinical implications of the brain–gut–enteric microbiota axis. Nat Rev Gastroenterol Hepatol 2009; 6(5):306-14.
20. Rochet V., Rigottier-Gois L., Ledaire A., Andrieux C., Sutren M., Rabot S., et al. Survival of Bifidobacterium animalis DN-173 010 in the Faecal Microbiota after Administration in Lyophilised Form or in Fermented Product – A randomised study in healthy adults. J Mol Microbiol Biotechnol 2008; 14(1-3):128-36.
21. Spiller R., Lam C. An Update on post-infectious irritable bowel syndrome: Role of genetics, immune activation, serotonin and altered microbiome. J Neurogastroenterol Motil 2012; 18(3):258-68.
22. Surawicz C.M., Brandt L.J., Binion D.G., Ananthakrishnan A.N., Curry S.R., Gilligan P.H., еt al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013; 108(4):478-98.
23. Tabbers M.M., Chmielewska A., Roseboom M.G., Boudet C., Perrin C., Szajewska H., Benninga M.A. Effect of the consumption of a fermented dairy product containing Bifidobacterium lactis DN-173 010 on constipation in childhood: a multicentre randomised controlled trial (NTRTC:1571). BMC Pediatr 2009; 9:22.
24. Tillisch K., Labus J., Kilpatrick L. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013; 144(7):1394-401.
25. Tilg H., Moschen A.R. Microbiota and diabetes: an evolving relationship. Gut 2014; 63(9):1513-21.
26. Valet P., Senard J.M., Devedjian J.C., Planat V., Salomon R., Voisin T., et al. Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. J Clin Invest 1993; 91:2049-55.
27. Vrieze A., van Nood E., Holleman F., Salojärvi J., Kootte R.S., Bartelsman J.F., et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012; 143(4):913-6.
28. Yang Y.X., He M., Hu G., Wei J., Pages P., Yang X.H., Bourdu-Naturel S. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol 2008; 14(40):6237-43.
Review
For citations:
Shulpekova Yu.O. The intestinal microbiome as a separate organ. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;24(6):82-88. (In Russ.)
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