SARS-CoV-2 Virus Protein in Lymph Node Biopsy from a Female Patient with Generalized Sarcoidosis Clinical Features
A. V. Bogacheva,
N. I. Kokina,
O. Yu. Zolnikova,
E. R. Buklis,
M. A. Tatarkina,
A. P. Kiryukhin,
M. V. Feldsherov,
E. A. Kogan,
V. T. Ivashkin https://doi.org/10.22416/1382-4376-2025-35-3-121-128
Abstract
Aim: to present a clinical case of generalized sarcoidosis that developed after suffering a new coronavirus infection.
Key points. Patient M., 45-years-old female, was hospitalized in the pulmonology department of the Clinic in October 2023 with complaints of shortness of breath that occurs with moderate physical exertion, sweating, increased fatigue. During the examination, the diagnosis was made: Main disease: Generalized sarcoidosis with lesions of the lungs, intrathoracic and peripheral lymph nodes, and spleen. Background disease: New coronavirus infection COVID-19 from January 2022. Prolonged postinfectious (new coronavirus infection) syndrome. Immunohistochemical examination of the biopsy of the supraclavicular lymph node in epithelioid cells, giant multinucleated cells in the cytoplasm revealed nucleocapsid and spike proteins of the SARS-CoV-2 virus. According to the treatment algorithms for sarcoidosis, 1st line therapy with systemic glucocorticosteroids was prescribed, followed by dose reduction and case monitoring.
Conclusion. A clinical case of generalized sarcoidosis with verified virus persistence in sarcoid granuloma cells 1.5 years after an acute episode of COVID-19 is presented.
About the Authors
A. V. Bogacheva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Arina V. Bogacheva —Physician, Departmentof Pulmonology, V.Kh. Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, build. 1
N. I. Kokina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Natalia I. Kokina — Cand. Sci. (Med.), Associate Professor of the Department of Internal Disease Propaedeutics, Head of the Department of Pulmonology, V.Kh. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, build. 1
O. Yu. Zolnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Oxana Yu. Zolnikova — Dr. Sci. (Med.), Professor of the Department of Internal Disease Propaedeutics, Gastro-enterology and Hepatology, N.V. Sklifosovsky Institute of Clinical Medicine
119435, Moscow, Pogodinskaya str., 1, build. 1
E. R. Buklis
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Elvira R. Buklis — Cand. Sci. (Med.), Physician at the Department of Pulmonology, V.Kh. Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, build. 1
M. A. Tatarkina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Maria A. Tatarkina — Cand. Sci. (Med.), Head of the Department, Ultrasound Diagnostics Specialist, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
A. P. Kiryukhin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Andrey P. Kiryukhin — Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
M. V. Feldsherov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Mikhail V. Feldsherov — Cand. Sci. (Med.), Head of the Department of Radiation Diagnostics, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
E. A. Kogan
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Evgenia A. Kogan — Dr. Sci. (Med.), Professor, Head of Department named after Academician A.I. Strukov
119435, Moscow, Pogodinskaya str., 1, build. 1
V. T. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Vladimir T. Ivashkin— Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology
119435, Moscow, Pogodinskaya str., 1, build. 1
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For citations:
Bogacheva A.V., Kokina N.I., Zolnikova O.Yu., Buklis E.R., Tatarkina M.A., Kiryukhin A.P., Feldsherov M.V., Kogan E.A., Ivashkin V.T. SARS-CoV-2 Virus Protein in Lymph Node Biopsy from a Female Patient with Generalized Sarcoidosis Clinical Features. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2025;35(3):121-128. https://doi.org/10.22416/1382-4376-2025-35-3-121-128
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