Microbiota of the Stomach and Duodenum and Functional Dyspepsia: Is There Any Connection?
https://doi.org/10.22416/1382-4376-2025-35-4-98-103
Abstract
Aim: to analyze the works published in the literature on the possible association of symptoms of functional dyspepsia (FD) with changes in the microbiota of the stomach and duodenum.
Key points. The data published in the literature indicate that there are significant differences between the composition of the microbiota of the stomach and duodenum in patients with FD and in healthy individuals. It is believed that changes in this composition can lead to an impairment of the integrity of the gastroduodenal mucosa with subsequent effects on the main pathogenetic factors of FD. Some studies have shown the effectiveness of probiotics in the treatment of FD patients. At the same time, the insufficient evidence base of the results does not currently allow us to give them an unambiguous assessment.
Conclusion. The relationship between changes in the microbiota of the stomach and duodenum requires further research.
About the Authors
A. А. Sheptulin
I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)
Arkadiy A. Sheptulin — Dr. Sci. (Med.), Professor of the De- partment of Propaedeutics of Internal Medicine, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine
119435, Moscow, Pogodinskaya str., 1, build. 1
Svetlana S Kardasheva
I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)
Russian Federation
Russian Federation
Svetlana S. Kardasheva — Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Medicine, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine
119435, Moscow, Pogodinskaya str., 1, build. 1
A. A. Kurbatova
I.M. Sechenov First Moscow State Medical University (Sechenovskiy University)
Russian Federation
Russian Federation
Anastasia A. Kurbatova — Cand. Sci. (Med.), Assisting Professor, Department of Propaedeutics of Internal Medicine, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine
119435, Moscow, Pogodinskaya str., 1, build. 1
References
1. Stanghellini V., Chan F.K.L., Hasler W.L., Malagelada J.R., Suzuki H., Tack J., et al. Gastroduodenal disorders. Gastroenterology. 2016;150(6):1380–92. DOI: 10.1053/j.gastro.2016.02.011
2. Koga Y. Microbiota in the stomach and application of probiotics to gastroduodenal diseases. World J Gastroenterol. 2022;28(47):6702–15. DOI: 10.3748/wjg.v28.i47.6702
3. Tsuda A., Suda W., Morita H., Takanashi K., Takagi A., Koga Y., et al. Influence of proton-pump inhibitors on the luminal microbiota in the gastrointestinal tract. Clin Transl Gastroenterol. 2015;6(6):e89. DOI: 10.1038/ctg.2015.20
4. Nakae H., Tsuda A., Matsuoka T., Mine T., Koga Y. Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt. BVJ Open Gastroenterol. 2016;3(1):e000109. DOI: 10.1136/bmjgast-2016-000109
5. Igarashi M., Nakae H., Matsuoka T., Takahashi S., Hisada T., Tomita J., et al. Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia. BMJ Open Gastroenterol. 2017;4(1):e000144. DOI: 10.1136/bmjgast-2017-000144
6. Zhong L., Shanahan E.R., Raj A., Koloski N.A., Fletcher L., Morrison M., et al. Dyspepsia and the microbiome: Time to focus on the small intestine. Gut. 2017;66(6):1168–9. DOI: 10.1136/gutjnl-2016-312574
7. Shanahan E.R., Kang S., Staudacher H., Shah A., Do A., Burns G., et al. Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia. Gut. 2023;72(5):929–38. DOI: 10.1136/gutjnl-2021-326158
8. Fukui A., Takagi T., Naito Y., Inoue R., Kashiwagi S., Mizushima K., et al. Higher levels of Streptococcus in upper gastrointestinal mucosa associated with symptoms in patients with functional dyspepsia. Digestion. 2020;101(1):38–45. DOI: 10.1159/000504090
9. Suárez-Jaramillo A., Baldeón M.E., Prado B., Fornasini M., Cohen H., Flores N., et al. Duodenal microbiome in patients with or without Helicobacter pylori infection. Helicobacter. 2020;25(6):e12753. DOI: 10.1111/hel.12753
10. Wang W., Liu Z., Zhang Y., Guo Z., Liu J., Li S., et al. Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy. Front Microbiol. 2023;14:1288920. DOI: 10.3389/fmicb.2023.1288920
11. Ohtsu T., Takagi A., Uemura N., Inoue K., Sekino H., Kawashima A., et al. The ameliorating effect of Lactobacillus gasseri OLL2716 on functional dyspepsia in Helicobacter pylori-uninfected individuals: A randomized controlled study. Digestion. 2017;96(2):92–102. DOI: 10.1159/000479000
12. Takagi A., Yanagi H., Ozawa H., Uemura N., Nakajima S., Inoue K., et al. Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-associated dyspepsia: A multicenter randomized double-blind controlled trial. Gastroenterol Res Pract. 2016;2016:7490452. DOI: 10.1155/2016/7490452
13. Ohtsu T., Haruma K., Ude Y., Takagi A. The effect of continuous intake of Lactobacillus gasseri OLL2716 on mild to moderate delayed gastric emptying: A randomized controlled study. Nutrients. 2021;13(6):1852. DOI: 10.3390/nu13061852
14. Sun E., Zhang X., Zhao Y., Li J., Sun J. Mu Z., et al. Beverages containing Lactobacillus paracasei LC-37 improved functional dyspepsia through regulation of the intestinal microbiota and their metabolites. J Dairy Sci. 2021;104(6):6389–98. DOI: 10.3168/jds.2020-19882
15. Wauters L., Slaets H., De Paepe K., Ceulemans M., Wetzels S., Geboers K., et al. Efficacy and safety of spore-forming probiotics in the treatment of functional dyspepsia: A pilot randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2021;6(10):784–92. DOI: 10.1016/S2468-1253(21)00226-0
16. Drago L., Meroni G., Pistone D., Pasquale L., Milazzo G., Monica F., et al. Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies. J Int Med Res. 2021;49(1):300060520982657. DOI: 10.1177/0300060520982657
17. Zhang J., Wu H.M., Wang X., Xie J., Li X., Ma J., et al. Efficacy of prebiotics and probiotics for functional dyspepsia: A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(7):e19107. DOI: 10.1097/MD.0000000000019107
18. Wauters L., Dickman R., Drug V., Mulak A., Serra J., Enck P., et al.; ESNM FD consensus group. United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia. United European Gastroenterol J. 2021;9(3):307–31. DOI: 10.1002/ueg2.12061
19. Tziatzios G., Gkolfakis P., Leite G., Mathur R., Damoraki G., Giamarellos-Bourboulis E.J., et al. Probiotics in functional dyspepsia. Microorganisms. 2023;11(2):351. DOI: 10.3390/microorganisms11020351
20. Sugano K., Tack J., Kuipers E.J., Graham D., ElOmar E.V., Miura S., et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64(9):1353–67. DOI: 10.1136/gutjnl-2015-309252
Review
For citations:
Sheptulin A.А., Kardasheva S.S., Kurbatova A.A. Microbiota of the Stomach and Duodenum and Functional Dyspepsia: Is There Any Connection? Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2025;35(4):98-103. https://doi.org/10.22416/1382-4376-2025-35-4-98-103
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