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Российский журнал гастроэнтерологии, гепатологии, колопроктологии

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Аденокарцинома пищевода: факторы риска и современные стратегии скрининга

https://doi.org/10.22416/1382-4376-2017-27-2-4-12

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Аннотация

Цель обзора. Отразить современные представления об эпидемиологической структуре и факторах риска аденокарциномы пищевода (АКП), проанализировать современные стратегии скрининга. Основные положения. АКП характеризуется стремительным ростом заболеваемости в развитых странах, а также высоким уровнем смертности. Как правило, АКП диагностируется достаточно поздно, на 3-4-й стадиях, что в значительной мере объясняет высокую смертность, так как возможности лечения на данных стадиях весьма ограничены. Основным доказанным фактором риска АКП является гастроэзофагеальная рефлюксная болезнь (ГЭРБ). АКП развивается обычно только как осложнение при пищеводе Баррета (ПБ), который служит следствием хронической ГЭРБ. Значимыми факторами риска АКП считаются мужской пол, европеоидная раса, ожирение и метаболический синдром, табакокурение, а также ряд генетических маркёров. Главной целью скрининговых программ АКП является ранняя диагностика заболевания, позволяющая обеспечить улучшение показателей выживаемости пациентов. Заключение. АКП развивается только у пациентов, страдающих ГЭРБ, с наибольшим риском у мужчин-европеоидов, курильщиков, лиц с избыточной массой тела и неконтролируемой симптоматикой. Своевременная диагностика ГЭРБ, ее эффективная терапия и динамическое наблюдение за больными с ПБ может предупредить развитие АКП.

Об авторах

И. В. Маев
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»
Россия


Д. Н. Андреев
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»
Россия


Ю. А. Кучерявый
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»
Россия


М. П. Щегланова
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»
Россия


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Для цитирования:


Маев И.В., Андреев Д.Н., Кучерявый Ю.А., Щегланова М.П. Аденокарцинома пищевода: факторы риска и современные стратегии скрининга. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2017;27(2):4-12. https://doi.org/10.22416/1382-4376-2017-27-2-4-12

For citation:


Mayev I.V., Andreyev D.N., Kucheryavy Y.A., Scheglanova M.P. Esophageal adenocarcinoma: risk factors and modern screening strategy. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(2):4-12. (In Russ.) https://doi.org/10.22416/1382-4376-2017-27-2-4-12

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