Diastolic dysfunction of myocardium and change of Q–T interval at chronic hepatitis C
Abstract
Aim of investigation. To study the functional changes of cardio-vascular system in patients with viral liver diseases.
Material and methods. Overall 150 patients with hepatitis virus C-associated liver diseases, including 80 patients with chronic hepatitis and 70 – with liver cirrhosis (LC) have been included in original study. All patient underwent electro- and echocardiography, and Reberg test with calculation of sodium filtration fraction. At ECG analysis corrected Q-T (Q-Tс) interval was calculated by Bazett's formula.
Results. In LC patients elongation of Q–Tc interval (432±21 ms) was revealed in comparison to patients with hepatitis (412±20 ms, р<0,001). Direct correlation of Q–T interval elongation and cirrhosis severity was marked. At echocardiography in LC patients the impairment of diastolic function and thickening of left ventricular walls was observed in comparison to hepatitis patients. Hypertrophy of myocardium was detected in 5,0% of patients with hepatitis and 17,1% of cirrhotic patients (р<0,05), diastolic dysfunction of left ventricle – in 20,0 and 50,0% respectively. The sodium filtration fraction in patients with decompensated LC was significantly lower, than in patients with compensated cirrhosis and hepatitis.
Conclusions. In patients at liver cirrhosis stage elongation of Q-Tc interval was significantly more frequent (40% of cases) in comparison to patients at hepatitis stage (6,25%). Mean duration of Q-Tc interval was 432±21 ms and 412±20 ms respectively (р<0,001). Diastolic function of myocardium considerably worsens at patients with cirrhosis in comparison to patients at hepatitis stage (Е/А ratio was 1,01±0,29 and 1,29±0,39 respectively, р<0,001). In patients with LC, especially at decompensation stage, significant decrease of sodium filtration fraction (0,52±0,21%) was marked in comparison to patients with hepatitis (0,80±0,29%, p=0,01) and compensated cirrhosis (0,75±0,22, p=0,021).
About the Authors
A. A. KonyshevaRussian Federation
Ye. A. Saginova
Russian Federation
S. V. Moiseyev
Russian Federation
T. N. Krasnova
Russian Federation
D. T. Abdurakhmanov
Russian Federation
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Review
For citations:
Konysheva A.A., Saginova Ye.A., Moiseyev S.V., Krasnova T.N., Abdurakhmanov D.T. Diastolic dysfunction of myocardium and change of Q–T interval at chronic hepatitis C. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2012;22(6):38-43. (In Russ.)
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