Ischemic heart disease and reflux-esophagitis: complexities of the differential diagnosis and treatment.
Abstract
The aim of review. To illuminate state-of-the-art of issue of ischemic heart disease and reflux-esophagitis combination and options of treatment of comorbide patients.
Original positions. Ischemic heart disease (IHD) and reflux-esophagitis (RE) are one of the most frequent diseases of cardio-vascular and alimentary systems. Common risk factors play important role in high prevalence of comorbide course of IHD and RE. Close anatomic position and common innervation of the heart and the esophagus trigger effect of gastroesophageal reflux on coronary vasoconstriction and disorders of heart rhythm at patients with IHD. Present studies show treatment effect, aimed on RE, at patients with IHD: decrease in number of myocardial ischemia and arrhythmia attacks. Application of prokinetics in complex treatment of RE at IHD patients is pathogenically proven. Combination of diseases requires long treatment, dictates necessity of choice of the safe agent, having no negative effect on the course of IHD.
Conclusion. Mutual effect on development and progression of symptoms of cardio-vascular and alimentary diseases causes not only certain diagnostic difficulties, but also necessitates search for improvement of diagnostic and treatment methods in comorbide patients with IHD and RE.
About the Authors
Yu. N. Belenkov
ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»
Russian Federation
Russian Federation
Ye. V. Privalova
ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»
Russian Federation
Russian Federation
A. O. Yusupova
ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»
Russian Federation
Russian Federation
M. V. Kozhevnikova
ГОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»
Russian Federation
Russian Federation
References
1. Мировая статистика здравоохранения. – ВОЗ, 2010.
2. Coronary heart disease statistics. – Mortality, 2008.
3. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee // Circulation. – 2009. – Vol. 119, N 3. – P. 480–486.
4. Udelson J.E., Spiegler E.J. Emergency department perfusion imaging for suspected coronary artery disease: the ERASE Chest Pain Trial // Md Med. – 2001. – Spring (suppl.) – P. 90–94.
5. Лазебник Л.Б., Машарова А.А., Бордин Д.С. и др. Многоцентровое исследование «Эпидемиология Гастроэзофагеальной Рефлюксной болезни в России» (МЭГРЕ): первые итоги // Экспер. клин. гастроэнтерол. – 2009. – № 6. – С. 4–12.
6. Ogden C., Yanovski S., Carrol M. The epidemiology of obesity // Gastroenterology. – 2007. – Vol. 132. – P. 2087–2102.
7. Kannel W.B., Cuppels L.A., Ramaswami R. et al. Higgis m regional obesity and risk of cardivascular disease; the Framingham study // J. Clin. Epidemiol. – 1991. – Vol. 44, N 2. – P. 183–190.
8. Peter W.F., Wilson M.D., Ralph B. D’Agostino et al. Prediction of coronary heart disease using risk factor categories // Circulation. – 1998. – Vol. 97. – P. 1837–1847.
9. Лупанов В.П. Ожирение как фактор риска развития сердечно-сосудистых катастроф // Рос. мед. журн. – 2003. – Т. 11, № 6. – С. 331–337.
10. Mohammed I., Nightingale P., Trudgill N.J. Risk factors for gastroesophageal reflux disease symptoms: A community study // Aliment. Pharmacol. Ther. – 2005. – Vol. 21, N 7. – P. 821–827.
11. Locke G.R. III, Talley N.J., Fett S.L. et al. Risk factors associated with symptoms of gastroesophageal reflux // Am. J. Med. – 1999. – Vol. 106. – P. 642–649.
12. El-Serag H., Graham D., Satia J. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis // Am. J. Gastroenterol. – 2005. – Vol. 100. – P. 1243–1250.
13. Kennedy T., Jones R. The prevalence of gastroesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms // Aliment. Pharmacol. Ther. – 2000. – Vol. 14. – P. 1589–1594.
14. Haque M., Wyeth J.W., Stace N.H. et al. Prevalence, severity and associated features of gastroesophageal reflux and dyspepsia: a population-based study // N. Z. Med. J. – 2000. – Vol. 113. – P. 178–181.
15. Wong W.M., Lai K.C., Lam K.F. et al. Prevalence, clinical spectrum and health care utilization of gastroesophageal reflux disease in a Chinese population: a population-based study // Aliment. Pharmacol. Ther. – 2003. – Vol. 18. – P. 595–604.
16. Kahrilas P.J., Gupta R.R. Mechanisms of acid reflux associated with cigarette smoking // Gut. – 1990. – Vol. 31. – P. 4–10.
17. Smit C.F., Copper M.P., van Leeuwen J.A. et al. Effect of cigarette smoking on gastropharyngeal and gastroesophageal reflux // Ann. Otol. Rhinol. Laryngol. – 2001. – P. 190–193.
18. Шаповалова М.М. Исследование качества жизни больных гастроэзофагеальной рефлюксной болезнью в сочетании с ишемической болезнью сердца и вопросы оптимизации лечения: Автореф. дис. ... канд. мед. наук. – Воронеж, 2007.
19. Онучина Е.В., Брикова С.И., Романенко Н.Д., Бродач Л.Н. Внепищеводная форма гастроэзофагеальной рефлюксной болезни у лиц пожилого и старческого возраста. Практическая гериатрия. – Иркутск, 2010. – С. 45–48.
20. Smith K.S., Papp C. Episodic, postural, and linked angina // BMJ. – 1962. – N 2 (5317). – P. 1425–1430.
21. Bedford E. Hiatus hernia and coronary disease // BMJ. – 1967. – N 4 (5575). – P. 352–353.
22. Chauhan A., Mullins P.A., Taylor G. et al. Cardioesophageal reflex: a mechanism for «linked angina» in patients with angiographycally proven coronary artery disease // J. Am. Coll. Cardiol. – 1996. – Vol. 27. – P. 1621–1628.
23. Bortolotti M., Labriola E., Bacchelli S. et al. Esophageal angina» in patients with angina pectoris: a possible side effect of chronic therapy with nitroderivates and Caantagonists // Ital. J. Gastroenterol. – 1992. – Vol. 24, N 7. – P. 405–408.
24. Фадеенко Г.Д. Внепищеводные проявления гастроэзофагеальной рефлюксной болезни: как их распознать? // Сучасна гастроентерологія. – 2004. – № 3. – С. 12–17.
25. Погромов А.П., Шишлов А.Ю., Стремоухов А.А, Дымшиц М.А. Результаты одновременного рН и ЭКГмониторирования у больных с кардиалгией // Клин. мед. – 2001. – № 1.
26. Логинов С.В., Козлова И.В., Шварц Ю.Г. Нарушения сердечного ритма и реполяризации миокарда у пациентов с коронарной патологией в сочетании с гастроэзофагеальной рефлюксной болезнью // Вестн. аритмол. – 2002. – № 30. – С. 58.
27. Dobrzycki S., Baniukiewicz A., Korecki J. et al. Does gastroesophageal reflux provoke the myocardial ischemia in patients with CAD? // Int. J. Cardiol. – 2005. – Vol. 104. – P. 67–72.
28. Manfrini O., Bazzocchi G., Luati A. et al. Coronary spasm reflects inputs from adjacent esophageal system // Am. J. Physiol. Heart Circ. Physiol. – 2006. – Vol. 290, N 5. – P. 2085–2091.
29. Johnson David A. MD. GERD Symptoms Linked to Cardiac Dysrhythmias // J. Watch Gastroenterol. – 2006. – September 29.
30. Schilling R.J., Kaye G.C. Paroxysmal atrial flutter suppressed by repair of a large paraesophageal hernia // Pacing Clin. Electrophysiol. – 1998. – Vol. 21, N 6. – P. 1303–1305.
31. Subhash C., Bajaj S., Enoumo P. Ragaza M.D. Herman silva deglutition tachycardia // Gastroenterology. – 1972. – Vol. 62, N 4. – P. 632–635.
32. Gillinov A.M., Rice T.W. Prandial atrial fibrillation: off-pump pulmonary vein isolation with hiatal hernia repair // Ann. Thorac. Surg. – 2004. – Vol. 78. – P. 1836–1838.
33. Kunz J.S., Hemann B., Edwin Atwood J. et al. Is there a link between gastroesophageal reflux disease and atrial fibrillation? // Clin. Cardiol. – 2009. – Vol. 32, N 10. – P. 584–587.
34. Engelmann M.D., Svendsen J.H. Inflammation in the genesis and perpetuation of atrial fibrillation // Eur. Heart J. – 2005. – N 26 (20). – P. 2083–2092.
35. Bytzer P. Goals of therapy and guidelines for treatment success in symptomatic gastroesophageal reflux disease patients // Am. J. Gastroenterol. – 2003. – Vol. 98, N 3. – P. 31–39.
36. Ткаченко Е.И., Успенский Ю.П., Каратеев А.Е. и др. Гастроэзофагеальная рефлюксная болезнь: патогенетические основы дифференцированной тактики лечения // Эксперим. клин. гастроэнтерол. – 2009. – № 2. – C. 104–114.
37. Исаков В.А. Новая парадигма ГЭРБ и длительная терапия ингибиторами протонного насоса // Эксперим. клин. гастроэнтерол. – 2006. – № 4. – C. 53–58.
38. Shonde A., Vinogradova Y., Leighton M. et al. Use of aspirin and proton pump inhibitors in 10 million patient database // Gut. – 2008. – Vol. 57 (suppl II). – A14.
39. Джулай Г.С., Секарёва Е.В. Гастроэзофагеальная рефлюксная болезнь: состояние и перспективы решения проблемы: Метод. рекомендации для врачей / Под ред. В.В. Чернина. – Тверь–М.: ИД «МЕДПРАКТИКАМ», 2010. – 48 с.
40. Hirofumi Nakamura, Gen Nakaji, Hideki Shimazu. A case of paroxysmal atrial fibrillation improved after the administration of proton pump inhibitor for associated reflux esophagitis // Fukuoka Acta Med. – 2007. – Vol. 98, N 6. – P. 270–276.
41. Weigl M., Gschwantler M., Gatterer E. et al. Reflux esophagitis in the pathogenesis of paroxysmal atrial fibrillation: results of a pilot study // South Med. J. – 2003. – Vol. 96, N 11. – P. 1128–1132.
42. Алексеева О.П., Долбин И.В., Пикулев Д.В. Сочетанное течение ишемической болезни сердца и гастроэзофагеальной рефлюксной болезни // НМЖ. – 2006. – № 7. – С. 7–12.
43. Budzyсski J., Kіopocka M., Pulkowski G. et al. The effect of double dose of omeprazole on the course of angina pectoris and treadmill stress test in patients with coronary artery disease--a randomised, double-blind, placebo controlled, crossover trial // Int. J. Cardiol. – 2008. – Vol. 127, N 2. – P. 233–239.
44. Российская гастроэнтерологическая ассоциация. Диагностика и лечение гастроэзофагеальной рефлюксной болезни. – М., 2010.
45. Pasricha P.J. Prokinetic agents, antiemetics agents used in irritable bowel syndrome // Goodman and Gilman’ss The Pharmacological Basis of Therapeutics / Eds. J.G. Hardman et al. – 10th ed. – New York, McGraw Hill Book Inc. – 2001. – 1021 p.
46. Wysowski D.K., Corken A., Gallo T.H. et al. Postmarketing reports of QT prolongation & ventricular arrhythmias in association with cisapride and food and Drug administration regulatory actions // Am. J. Gastroenterol. – 2001. – Vol. 96. – P. 1698–1703.
47. Лиманкина И.Н. // Вестн. аритмол. – 2008. – № 52. – С. 66–71.
48. Savant P., Das H.S., Desai N. et al. Comparativ evaluation of the effiacacy and tolerability of itoprid hydrochloride and domperidone in patients with non-ulcer dyspepsia // JAPI. – 2004. – Vol. 52. – P. 626–628.
49. Yong Sung Kim, Tae Hyeon Kim, Chang Soo Choi et al. Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study // World J. Gastroenterol. – 2005. – N 11 (27). – P. 4210–4214.
50. Seema Gupta, Vinod Kapoor B.M., Gupta B. et al. Effect of itopride HCl on QT interval in healthy adult volunteers // Clin. Pharmacol. JK-Practitioner. – 2005. – Vol. 12, N 4. – P. 207–210.
51. Takuma K., Ohtani K., Kotaki H., Iga T. Comparative studies of drug induced arrhythmia in guinea pigs by cisapride and itopride hydrochloride: prolongation of QT interval and search for alternative drugs to avoid side effect. The Annual meeting of Hospital and Pharmaceutical society of Japan. – Nagoya. Sep 13–14, 1997.
52. Kamath Vinod K., Verghese J., Bhatia S. Comparative evaluation of the efficacy and tolerability of Itopride and Metoclopramide in patients with NUD // JAMA. – 2003. – Vol. 2, N 8. – P. 95–98.
53. Kim J.K., Moon S.B., Choi H. et al. An effectiveness and safety of Itopride versus Cisapride in functional dyspepsia // Kor. J. Gastroenterol. – 1999. – Vol. 33. – P. 749–756.
54. Ganaton Post Marketing Surveillance Study Group // Gastroenterology Today. – 2004. – Vol. 8. – P. 1–8.
Review
For citations:
Belenkov Yu.N., Privalova Ye.V., Yusupova A.O., Kozhevnikova M.V. Ischemic heart disease and reflux-esophagitis: complexities of the differential diagnosis and treatment. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2011;21(3):4-12. (In Russ.)
Views:
203
Email this article 
