Gastroesophageal reflux disease at children: epidemiology, diagnostic criteria, prognosis
Abstract
The aim of review. To present world literature data on epidemiology, features of course and diagnostics of gastroesophageal reflux disease (GERD) at children at different age.
Original positions. Now the major attention is given by gastroenterologists and pediatrists to GERD at children, probability of its progression and development of complications in advanced age. Manifestations of GERD at children are different in various age-grades. At the first year of life of GERD manifests by regurgitation and vomiting. In most of the cases these symptoms are regarded to be physiological. However frequent regurgitation in this period of life is related to probability of further development of typical symptoms of GERD in these children. Along with growth, symptoms of GERD in children become more specific and similar to manifestations of disease at adults for whom the heartburn and acidic belching are considered as the most typical complaints. Basic methods of instrumental diagnostics of GERD and its complications at children, as well as at adults, include esophagogastroduodenoscopy and 24-hour esophageal and gastric рН-monitoring. However at children, there is no interrelation of clinical, endoscopic and рН-metrical changes severity.
Conclusion. Above mentioned data testifies the absence of clear diagnostic criteria of GERD at children. For more exact diagnostics of GERD at pediatric age complex investigation of the child is required.
About the Authors
E. M. MukhametovaRussian Federation
S. I. Erdes
Russian Federation
References
1. Ивашкин В.Т., Трухманов А.С. Современный подход к терапии гастроэзофагеальной рефлюксной болезни во врачебной практике // Рус. мед. журн. – 2003. – № 2. – С. 43–48.
2. Лярская Н.В. Частота и распространенность неэрозивной и эрозивной гастроэзофагеальной рефлюксной болезни у детей // Материалы XIV конгресса детских гастроэнтерологов России. – М., 2007.
3. Семенюк Л.А., Санникова Н.Е. Гастроэзофагеальная рефлюксная болезнь и Нр-ассоциированный хронический гастрит у детей и подростков // Материалы XIII конгресса детских гастроэнтерологов России. – М., 2006.
4. Campanozzi A., Boccia G., Pensabene L. et al. Prevalence and natural history of gastroesophageal reflux: Pediatric prospective survey // Pediatrics. – 2009. – Vol. 3, N 123. – P. 779–783.
5. Chitkara D.K., Talley N.J., Weaver A.L. et al. Incidence of presentation of common functional gastrointestinal disorders in children from birth to 5 years: A cohort study // Clin. Gastroenterol. Hepatol. – 2007. – Vol. 5, N 2. – P. 186–191.
6. Costa A.J.F., Silva G.A.P. et al. Prevalence of pathologic gastroesofageal reflux in regurgitant infants // J. de Pediatria (Brazil). – 2004. – Vol. 4, N 80. – P. 115–120.
7. De S., Rajeshwari K., Kalra K.K. et al. Gastroesophageal reflux in infants and children in North India // Trop Gastroenterol. – 2001. – Vol. 22. – P. 99–102.
8. El-Serag H.B., Bailey N.R., Gilger M.A., Rabeneck L. Endoscopic manifestations of gastroesophageal reflux disease in patients between 18 months and 25 years without neurological deficits // Am. J. Gastroenterol. – 2002. – Vol. 97, N 7. – P. 1635.
9. Gilger M.A., El-Serag H.B., Gold B.D. et al. Prevalence of endoscopic findings of erosive esophagitis in children: a population-based study // J. Pediatr. Gastroenterol. Nutr. – 2008. – Vol. 47. – P. 141–146.
10. Gunasekaran T.S., Dahlberg M., Ramesh P., Namachivayam G. Prevalence and associated features of gastroesophageal reflux symptoms in a Caucasian-predominant adolescent school population // Dig. Dis. Sci. – 2008. – Vol. 53, N 9. – P. 2373–2379.
11. Gupta S.K., Hassall E., Chiu Y.L. et al. Presenting symptoms of nonerosive and erosive esophagitis in pediatrics patients // Dig. Dis. Sci. – 2006. – Vol. 51, N 5. – P. 858–863.
12. Hassall E. Barrett’s esophagus: new definitions and approaches in children // J. Pediatr. Gastroenterol. Nutr. – 1993. – Vol. 16. – P. 345–364.
13. Hassall E., Dimmick J.E., Magee J.F. Adenocarcinoma in childhood Barrett’s esophagus: case documentation and the need for surveillance in children // Am. J. Gastroenterol. – 1993. – Vol. 88, N 2. – P. 282–288.
14. Mahajan L., Wyllie R., Oliva L. et al. Reproducibility of 24-hour intraesophageal pH monitoring in pediatric patients // Pediatrics. – 1998. – Vol. 101. – P. 260– 263.
15. Martin A.J., Pratt N., Kennedy J.D. et al. Natural history and familial relationships of infant spilling to 9 years of age // Pediatrics. – 2002. – Vol. 109. – P. 1061.
16. Miyazawa R., Tomomasa T., Kaneko H. et al. Prevalence of gastroesophageal reflux-related symptoms in Japanese infants // Pediatr. Int. – 2002. – Vol. 44. – P. 513– 516.
17. Nelson S.P., Chen E.H., Syniar G.M. et al. One-year follow-up of symptoms of gastroesophageal reflux during infancy. Pediatric Practice Research Group // Pediatrics. – 1998. – Vol. 102. – P. 67.
18. Nelson S.P., Chen E.H., Syniar G.M. et al. Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group // Arch. Pediatr. Adolesc. Med. – 1997. – Vol. 151. – P. 569–572.
19. Nelson S.P., Chen E.H., Syniar G.M., Christoffel K.K. Prevalence of symptoms of gastroesophageal reflux during childhood: a pediatric practice-based survey. Pediatric Practice Research Group // Arch. Pediatr. Adolesc. Med. – 2000. – Vol. 154. – P. 150.
20. Orenstein S.R., Cohn J.F., Shalaby T.M., Kartan R. Reliability and validity of an infant gastroesofageal reflux questionnaire // Clin. Pediatr. (Phila). – 1993. – Vol. 32. – P. 472–484.
21. Orenstein S.R., Izadnia F., Khan S. Gastroesophageal reflux disease in children // Gastroenterol. Clin. North Am. – 1999. – Vol. 28. – P. 947–969.
22. Orenstein S.R., Shalaby T.M., Cohn J.F. Reflux symptoms in 100 normal infants: diagnostic validity of the infant gastroesophageal reflux questionnaire // Clin. Pediatr. (Phila). – 1996. – Vol. 35. – P. 607–614.
23. Osatakul S., Sriplung H., Puetpaiboon A. et al. Prevalence and natural course of gastroesophageal reflux symptoms: a 1-year cohort study in Thai infants // J. Pediatr. Gastroenterol. Nutr. – 2002. – Vol. 34. – P. 63– 67.
24. Rasquin-Weber A., Hyman P.E., Cucchiara S. et al. Childhood functional gastrointestinal disorders // Gut. – 1999. – Vol. 45, N 2. – P. 60–68.
25. Rudolph C.D., Mazur L.J., Liptak G.S. et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition // J. Pediatr. Gastroenterol. Nutr. – 2001. – Vol. 32, N 2. – P. 1.
26. Salvatore S., Hauser B., Vandemaele K., Vandenplas Y. Gastroesophageal reflux disease in infants: how much is predictable with questionnaires, pH-metry, endoscopy and histology? // J. Pediatr. – Gastroenterol. Nutr. – 2005. – Vol. 40, N 2. – P. 210–215.
27. Shaheen N., Ransohoff D.F. Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review // JAMA. – 2002. – Vol. 287, N 15. – P. 1972–1981.
28. Tolia V., Wuerth A., Thomas R. Gastroesophageal reflux disease: review of presenting symptoms, evaluation, management and outcome in infants // Dig. Dis. Sci. – 2003. – Vol. 9, N 48. – P. 1723–1729.
29. Vakil N., van Zanten S.V., Kahrilas P. et al. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am. J. Gastroenterol. – 2006. – Vol. 101, N 8. – P. 1900–1920.
30. Vandenplas Y., Hassall E. Mechanisms of gastroesophageal reflux and gastroesophageal reflux disease // J. Pediatr. Gastroenterol. Nutr. – 2002. – Vol. 35. – P. 119–136.
Review
For citations:
Mukhametova E.M., Erdes S.I. Gastroesophageal reflux disease at children: epidemiology, diagnostic criteria, prognosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2010;20(1):75-81. (In Russ.)