Gastroesophageal reflux disease and the functional diseases of gastro-intestinal tract: are there any interrelations?
Abstract
The aim of review. To discuss possible relation of gastroesophageal reflux disease (GERD) and other functional diseases of gastro-intestinal tract (GIT) and demonstrate, which forms of GERD can be taken into account from the standpoints of functional diseases.
Received data. It is shown, that the GERD is frequently combined with functional dyspepsia and irritable bowel syndrome. It can be caused by common pathophysiological mechanisms of these diseases. Within the framework of non-erosive form of GERD it is possible to define 2 subgroups of patients, at which: 1)correlation of clinical symptoms to episodes of physiological gastroesophageal reflux (GER) is present – patients with hypersensitive esophagus or 2) clinical symptoms are not related to GER at all – patients with functional heartburn, which can be considered within the framework of functional pathology. Further studies are necessary to improve diagnostics and treatment of these forms of GERD.
Conclusion. Within the framework of GERD there are forms of disease which can be assessed from positions of functional disorders of GIT.
References
1. Agreus L., Svardsudd K., Nyren O. et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. – Gastroenterology. – 1995. – Vol. 109. – P. 671–680.
2. Armstrong D. Symptom assessment: methods and content // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 184–192.
3. Broekaert D., Fischler B., Sifrim D. et al. Influence of citalapram, a selective serotonin reuptake inhibitor on esophageal hypersensitivity: a double-blind, placebo-controlled study // Aliment. Pharmacol. Ther. – 2006. – Vol. 23. – P. 365–370.
4. Erkrankungen der Verdauungsorgane / bearb. von G.V. Bergmann et al. – 1. Teil. – Berlin: Springer Verlag, 1926. – 1051 s.
5. Fass R., Tougas G. Functional heartburn: the stimulus, the pain and the brain. – Gut. – 2002. – Vol. 51. – P. 885–892.
6. Focca R., Riddell R., Takubo K. Microscopic esophagitis: interobserver consistency using consensus-based criteria // Gut. – 2007. – Vol. 56 (suppl. III). – P. 75.
7. Galmiche J.P., Clouse R.E., Balint A. et al. Functional esophageal disorders // Gastroenterology. – 2006. – Vol. 130. – P. 1459–1465.
8. Goldkind L. Meeting expectations in FD: clinical and regulatory objectives. Regulatory viewpoint // Functional dyspepsia: current evidence and cutting edge outcomes . – Abstract book. – Montreal, 2005. – P. 19.
9. Heading R.C. Complete remission in GERD: dream or reality // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 198–101.
10. Hunt R.H., Tytgat G., Malfertheiner P. et al. Whistler consensus // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 47–50.
11. Locke G.R., Zinsmeister A.R., Fett S.L. et al. Overlap of gastrointestinal symptom complexes in a US community // Neurogastroenterol. Motil. – 2005 – Vol. 17.
12. – P. 29–34.
13. Malfertheiner P., Mönkemüller K., Wex T. GERD: endoscopic assesment: a reconcillation with symptoms // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 193–197.
14. McQuaid K.R. Dyspepsia // Sleisenger and Fordtran’s gastrointestinal and liver disease / Ed. M. Feldman et al. 7th– ed. – Philadelphia–London–Toronto–Montreal– Sydney–Tokyo, 2002. – P. 102–118.
15. Modlin I.M., Hunt R. Whistler meeting // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 45–46.
16. Mőnnikes H., Schwan T., Sander P. Request as a potential tool for the assesment of treatment response in functional gastrointestinal disorders // Gut. – 2008. – Vol. 57 (suppl. II). – P. 322.
17. Neumann N., Mönkemüller K., Fry L.C. Dilated intercellular spaces of esophageal epithelium in non-erosive and erosive reflux disease patients and appropriate controls // Gut. – 2007. – Vol. 56 (suppl. III). – P. 206.
18. Nunez-Rodriguez H., Miranda-Sivela A., Madrigal R. et al. Gastroesophageal reflux disease and psychological factors // Gut. – 2007. – Vol. 56 (suppl. III). – P. 206.
19. QuigleyE.M.M.NERD,GERDandbeyond:aconsideration of the expanding spectrum of gastroesophageal reflux disease // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 175–180.
20. Sarkar S. et al. Contribution of central sensitisation to the development of non-cardiac chest pain // Lancet. – 2000. – Vol. 356. – P. 1154–1159.
21. Sarkar S., Thompson D.G., Woolf C.J. et al. Patients with chest pain and occult gastroesophageal reflux demonstrate visceral pain hypersensitivity which may be partially responsive to acid supression // Am. J. Gastroenterol. – 2004. – Vol. 99. – P. 1998–2006.
22. Stanghellini V., Barbara G., Cogliandro R. Overlap between GERD and IBS: irrefutable but subtle // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 114–117.
23. Tack J. What are we feeling: motility and hypersensitivity in GERD // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 163–167.
24. Tack J., Talley N.J., Camilleri M. et al. Functional gastroduodenal disorders // Gastroenterology. – 2006. – Vol. 130. – P. 1466–1479.
25. Talley N.J. and the working team for functional gastroduodenal disorders. Functional gastroduodenal disorders // The functional gastrointestinal disorders. – Boston–New York–Toronto–London, 1994. – P. 71–113.
26. Talley N.J., Zinsmeister A.R., Schleck C.D. et al. Dyspepsia and dysрepsia subgroups: a population-based study // Gastroenterology. – 1992. – Vol. 102. – P. 1259–1268.
27. Thomson A.B.R. ReQuest: pain, pH, pills and promises // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 81–86.
28. Tytgat G.N.J. Gastroesophageal reflux disease // J. Clin. Gastroenterol. – 2007. – Vol. 41 (suppl. 2). – P. 223–225.
Review
For citations:
Sheptulin A.A., Vize-Khripunova M.A. Gastroesophageal reflux disease and the functional diseases of gastro-intestinal tract: are there any interrelations? Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2010;20(4):44-48. (In Russ.)
Views:
71
Email this article 
