Hepatotoxic chemotherapy of colorectal cancer: state-of-the-art
Abstract
The aim of review. To analyze state-of-the-art of surgical treatment of patients after neoadjuvant chemotherapy.
Original positions. Liver is the first organ on a way of hematogenous spread of tumor. Now the majority of oncologists accepted the point, that only treatment, that provide high survival rate, is surgical. In the last decade increasing numbers of patients are operated after a long-term chemotherapy. Taking into account systemic action of cytotoxic drugs, their severe immune-suppressive and hepatotoxic features, it was possible to expect dramatic deterioration of postoperative morbidity and mortality figures. However data of the majority of studies deny this assumption. Moreover, changes of hepatic parenchyma and as the consequence, course of perioperational period can depend on composition and mode of chemotherapy.
Conclusion. The knowledge of spectrum of hepatotoxic of cytotoxic drugs with comprehension of the processes, that determine functional and regenerative capacity of the liver, allows to choose optimal approach of the combined treatment of patients with colorectal cancer metastases.
About the Authors
L. O. PolishchukRussian Federation
L. D. Kozmin
Russian Federation
D. L. Stroyakovsky
Russian Federation
Ye. S. Dorovskoy
Russian Federation
O. G. Skipenko
Russian Federation
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For citations:
Polishchuk L.O., Kozmin L.D., Stroyakovsky D.L., Dorovskoy Ye.S., Skipenko O.G. Hepatotoxic chemotherapy of colorectal cancer: state-of-the-art. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(5):10-19. (In Russ.)
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