Potential of magnetic-resonance tomography in differential diagnostics of liver cirrhosis and hepatocellular carcinoma
Abstract
The aim of review. To characterize potential of magnetic-resonance tomography (MRI) for differential diagnostics of cirrhosis and cancer of the liver.
Original positions. Initial MR-signs of liver cirrhosis include dilation of periportal space in portal area and atrophy of medial segment of the left lobe. Enlargement of gallbladder fossa may be a sign of progression of cirrhotic process. MR-signs of hepatocellular cancer include development of hyperintensive foci on a general background of low intensity parenchyma. Advantage of application of contrast agents on the basis of chelates of gadolinium, and nonspecific contrast agents such as cell-specific supermagnetic and paramagnetic contrast agents (iron oxides, manganese) during the study consist in capability of visualization of malignant focus of in regenerative node «node in the node» phenomenon. Feature that causes unequal accumulation of contrast agent in benign and malignant liver tissue is the absence of Kupffer’s cells phagocyting particles of the agent in neoplastic focus. Advantage of various modes of the study in diagnostics of focal lesions in liver is substantial increase of sensitivity of used methods.
Conclusion. At suspicion for volume lesions of the liver and cirrhosis MRI is justified and brings important diagnostic information, especially with application of contrast agents.
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Review
For citations:
Kulyushina Ye.A. Potential of magnetic-resonance tomography in differential diagnostics of liver cirrhosis and hepatocellular carcinoma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(5):20-23. (In Russ.)
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