Pathogenic role of hydrochloric acid in gastroesophageal reflux disease

Abstract

The aim. To show the role of hydrochloric acid in development of esophageal mucosa changes in patients with gastroesophageal reflux disease (GERD).

Recent literature data. Data of various studies testify the damaging effect of hydrochloric acid, pepsin, bile acids, oxidative stress on mucosa of esophagus that results in development of GERD.

Conclusion. Development of painful sensations in patients with GERD can be related to direct action of hydrochloric acid on damaged mucosa (at erosive form), and hypersensitivity of mucosa to hydrochloric acid (at non-erosive form).