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Clinical Recommendations of the Russian Gastroenterological Association for the Diagnosis and Treatment of Autoimmune Gastritis

https://doi.org/10.22416/1382-4376-2025-35-6-115-136

Abstract

Aim: to present clinical guidelines describing the clinical, laboratory, endoscopic and histological characteristics of autoimmune gastritis (AIG) and to provide information support for decision-making on diagnosis, prognosis assessment and choice of management tactics for patients with AIG.

Key points. AIG is an organ-specific autoimmune disease characterized by the presence of antibodies to parietal cells and/or intrinsic factor, in which inflammation and atrophy are limited to the gastric mucosa, functionally manifesting as hypo- and achlorhydria. There is evidence of an increase in the incidence of AIG worldwide. AIG is often associated with autoimmune thyroiditis (up to 40 % of cases), type 1 diabetes mellitus, and autoimmune polyglandular syndrome. Data on laboratory diagnostic methods, esophagogastroduodenoscopy, and histological examination of biopsies are presented, with an analysis of the endoscopic and histological picture typical of AIG. When AIG is combined with H. pylori infection, eradication therapy is recommended. In addition to symptomatic treatment and treatment of anemia, long-term rebamipide therapy is recommended to potentiate the protective properties of the gastric mucosa. Endoscopic monitoring of patients with AIG is recommended at intervals of once every 3 years.

About the Authors

V. T. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Vladimir T. Ivashkin — Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology, N.V. Sklifosovsky Institute of Clinical Medicine

119435, Moscow, Pogodinskaya str., 1, build. 1 


I. V. Maev
Russian University of Medicine
Russian Federation

Igor V. Maev — Dr. Sci. (Med)., Professor, Academician of the Russian Academy of Medical Sciences, Head of the Department of Propaedeutics of Internal Diseases and Gastroenterology

127473, Moscow, Delegatskaya str., 20, build. 1 


T. L. Lapina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatiana L. Lapina — Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases

119991, Moscow, Pogodinskaya str., 1, build. 1 


A. S. Trukhmanov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexander S. Trukhmanov — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology of the N.V. Sklifosovsky Institute of Clinical Medicine

119435, Moscow, Pogodinskaya str., 1, build. 1 


D. E. Rumyantseva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Diana E. Rumyantseva — Cand. Sci. (Med.), Physician at the Department of Gastroenterology, V.Kh. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1 


O. A. Storonova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Olga A. Storonova — Cand. Sci. (Med.), Physician at the Department of Functional Diagnostics, V.Kh. Vasilenko Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1 


A. V. Paraskevova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anna V. Paraskevova — Cand. Sci. (Med.), Physician of the Department of Functional Diagnostics, V.Kh. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1 


A. S. Tertychnyy
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexander S. Tertychnyy — Dr. Sci. (Med.), Professor, Head of the Laboratory of Electron Microscopy and Immunohistochemistry, Institute of Clinical Morphology and Digital Pathology

119435, Moscow, Pogodinskaya str., 1, build. 1 


A. P. Kiryukhin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Andrey P. Kiryukhin— Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

119435, Moscow, Pogodinskaya str., 1, build. 1 


P. V. Pavlov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Pavel V. Pavlov — Cand. Sci. (Med.), Associate Professor at the Department of Surgery; Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

119435, Moscow, Pogodinskaya str., 1, build. 1 


S. R. Abdulkhakov
Kazan (Volga Region) Federal University ; Kazan State Medical University
Russian Federation

Sayar R. Abdulkhakov — Cand. Sci. (Med), Head of the Department of Internal Diseases, Institute of Fundamental Medicine and Biology; Associate Professor of the Department of Outpatient Therapy and General Medical Practice

420012, Kazan, Kremlevskaya str., 18 


O. P. Alekseeva
Privolzhsky Research Medical University
Russian Federation

Olga P. Alekseeva — Dr. Sci. (Med.); Professor of the Department of Hospital Therapy and General Medical Practice named after V.G. Vogralik; Chief Gastroenterologist 

603005, Nizhny Novgorod, Minina i Pozharskogo sq., 10/1 


S. A. Alekseenko
Far Eastern State Medical University
Russian Federation

Sergei A. Alekseenko — Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy; Chief Gastroenterologist of the Far-Eastern Federal District

680000, Khabarovsk, Muravyova-Amurskogo str., 35 


D. N. Andreev
Russian University of Medicine
Russian Federation

Dmitry N. Andreev — Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology

127473, Moscow, Delegatskaya str., 20, build. 1 


I. G. Bakulin
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Igor G. Bakulin — Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Medicine, Gastroenterology and Dietetics named after S.M. Ryss

191015, St. Petersburg, Kirochnaya str., 41 


N. V. Bakulina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Natalia V. Bakulina — Dr. Sci. (Med.), Head of the Department of Internal Medicine, Nephrology, General and Clinical Pharmacology with a course in Pharmacy

191015, St. Petersburg, Kirochnaya str., 41 


D. S. Bordin
Russian University of Medicine ; A.S. Loginov Moscow Clinical Scientific Center ; Tver State Medical University
Russian Federation

Dmitry S. Bordin — Dr. Sci. (Med.), Professor of the Department of Propaedeutic of Internal Diseases and Gastroenterology; Head of the Department of Pancreatic, Biliary and Upper Digestive Tract Disorders; Professor of the Department of General Medical Practice and Family Medicine

111123, Moscow, Entuziastov highway, 86, build. 6 


Z. M. Galeeva
Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education
Russian Federation

Zarina M. Galeeva — Cand. Sci. (Med.), Associate Professor of the Department of Therapy, Geriatrics and Family Medicine

420012, Kazan, Butlerova str., 36 


N. N. Dekhnich
Smolensk State Medical University
Russian Federation

Natalia N. Dekhnich — Dr. Sci. (Med.), Professor of the Department of Faculty Therapy, Vice-Rector for Continuing Professional Education and Development of Regional Healthcare

214019, Smolensk, Krupskoy str., 28 


A. V. Kononov
Omsk State Medical University
Russian Federation

Alexey V. Kononov — Dr. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy

644099, Omsk, Lenina str., 12 


N. V. Korochanskaya
Kuban State Medical University ; Krai Clinical Hospital No. 2
Russian Federation

Natalia V. Korochanskaya — Dr. Sci. (Med.), Professor of the Department of Surgery No. 3 of the Faculty of Advanced Training and Postgraduate Studies; Head of the Gastroenterological Center

350063, Krasnodar, Mitrofana Sedina str., 4 


R. O. Kuvaev
Clinical Oncological Hospital ; N.I. Pirogov Russian National Research Medical University
Russian Federation

Roman O. Kuvaev — Cand. Sci. (Med.), Endoscopist, Gastroenterologist, Clinical Oncological Hospital; Associate Professor of the Department of Gastroenterology, Faculty of Postgraduate Education

117997, Moscow, Ostrovityanova str., 1 


Yu. A. Kucheryavyy
Ilyinskaya Hospital
Russian Federation

Yury A. Kucheryavyy — Cand. Sci. (Med.), Head of Gastroenterology Department; Scientific Advisor, DiaGastro Educational Programme for Physicians in Gastroenterology and Related Specialties of the Eventum Medical Consulting agency

143421, Moscow region, Krasnogorsk, Glukhovo village, Rublevskoe Predmestye str., 2, build. 2


M. A. Livzan
Omsk State Medical University
Russian Federation

Maria A. Livzan — Dr. Sci. (Med.), Professor, Correspondent Member of the Russian Academy of Sciences, Head of Faculty Therapy and Gastroenterology Department, Rector

644099, Omsk, Lenina str., 12 


M. F. Osipenko
Novosibirsk State Medical University
Russian Federation

Marina F. Osipenko — Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Diseases

630091, Novosibirsk, Krasny ave., 52 


S. S. Pirogov
Moscow Research Oncological Institute named after P.A. Gertsen — Branch of National Medical Research Radiological Center
Russian Federation

Sergey S. Pirogov — Dr. Sci. (Med.), Head of the Department of Endoscopy

125284, Moscow, Vtoroy Botkinsky lane, 3 


A. S. Sarsenbaeva
South Ural State Medical University
Russian Federation

Aiman S. Sarsenbaeva — Dr. Sci. (Med.), Professor of the Department of Therapy, Dean of the Institute of Continuing Professional Education

454092, Chelyabinsk, Vorovskogo str., 64 


V. I. Simanenkov
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Vladimir I. Simanenkov — Dr. Sci. (Med.), Professor of the Department of Internal Medicine, Nephrology, General and Clinical Pharmacology with a course in Pharmacy

191015, St. Petersburg, Kirochnaya str., 41 


E. A. Troshina
Endocrinology Research Center
Russian Federation

Ekaterina A. Troshina — Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Institute of Clinical Endocrinology, Deputy Director

17292, Moscow, Dmitriya Ulyanova str., 11 


E. D. Fedorov
Far Eastern State Medical University ; N.I. Pirogov Russian National Research Medical University
Russian Federation

Evgeny D. Fedorov — Dr. Sci. (Med.), Professor, Chief Researcher, Research Laboratory of Surgical Gastroenterology and Endoscopy; Clinical Head of the Department of Endoscopic Surgery

117997, Moscow, Ostrovityanova str., 1 


I. B. Khlynov
Ural State Medical University
Russian Federation

Igor B. Khlynov - Dr.Sci.(Med.),AssociateProfessoroftheDepartment of Intermediate Level Therapy and Geriatrics; Chief Gastroenterologist

620028, Yekaterinburg, Repina str., 3 


V. V. Tsukanov
Federal Research Center “Krasnoyarsk Science Center of Siberian Branch of the Russian Academy of Sciences”, Separate Division “Scientific Research Institute of Medical Problems of the North”
Russian Federation

Vladislav V. Tsukanov — Dr. Sci. (Med.), Professor, Head of the Clinical Department of Adult and Infant Digestive Pathology; Chief Gastroenterologist of the Siberian Federal District

660022, Krasnoyarsk, Partizana Zheleznyaka str., 3g 


References

1. Rugge M., Genta R.M., Malfertheiner P., Dinis-Ribeiro M., El-Serag H., Graham D.Y., et al.; RE.GA.IN. RE.GA.IN.: The Real-world Gastritis Initiative-updating the updates. Gut. 2024;73(3):407–41. DOI: 10.1136/gutjnl-2023-331164

2. Losik Ye.A., Selivanova L.S., Antonova T.V., Lapina T.L., Tertychny A.S., Ivashkin V.T. Morphological diagnostic criteria of autoimmune gastritis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(5):13–20. (In Russ.). DOI: 10.22416/1382-4376-2016-5-13-20

3. Kiryukhin A.P., Tertychnyy A.S., Pavlov P.V., Fedorenko A.A., Nagornaya D.P., Marenich N.S., et al. Autoimmune gastritis: Focus on endoscopic and morphological characteristics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(1):58– 69. (In Russ.). DOI: 10.22416/1382-4376-2024-34-1-58-69

4. Lenti M.V., Rugge M., Lahner E., Miceli E., Toh B.H., Genta R.M., et al. Autoimmune gastritis. Nat Rev Dis Primers. 2020;6(1):56. DOI: 10.1038/s41572-020-0187-8

5. Castellana C., Eusebi L.H., Dajti E., Iascone V., Vestito A., Fusaroli P., et al. Autoimmune Atrophic gastritis: A clinical review. Cancers (Basel). 2024;28;16(7):1310. DOI: 10.3390/cancers16071310

6. Soykan İ., Er R.E., Baykara Y., Kalkan C. Unraveling the mysteries of autoimmune gastritis. Turk J Gastroenterol. 2024;36(3):135–44. DOI: 10.5152/tjg.2024.24563

7. Bordin D.S., Livzan M.A., Mozgovoi S.I., Gaus O.V. Autoimmune gastritis and Helicobacter pylori infection: Molecular mechanisms of relationship. Int J Mol Sci. 2025;26(16):7737. DOI: 10.3390/ijms26167737

8. Polyakova V., Bodunova N., Rumyantsev K., Khatkov I., Bordin D., Bilyalov A., et al. Genetic determinants of autoimmune gastritis. BioNanoScience. 2023;13(1):322–9. DOI: 10.1007/s12668-023-01068-3

9. Tertychnyy A.S., Pachuashvili N.V., Nagornaya D.P., Lapina T.L., Losik E.A., Ponomarev A.B., et al. Clinical and morphological features of dysplasia and early gastric cancer in the patients with autoimmune gastritis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2023;33(3):16–33. (In Russ.). DOI: 10.22416/1382-4376-2023-33-3-16-33

10. Losik Ye.A., Ivashkin V.T. Autoimmune gastritis pathogenesis and risk factors of stomach malignant neoplasia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(4):81–5. (In Russ.).

11. Vavallo M., Cingolani S., Cozza G., Schiavone F.P., Dottori L., Palumbo C., et al. Autoimmune gastritis and hypochlorhydria: Known concepts from a new perspective. Int J Mol Sci. 2024;25(13):6818. DOI: 10.3390/ijms25136818

12. La Rosa S., Rindi G., Solcia E., Tang L.H. Neuroendocrine neoplasms. In: The WHO Classification of Tumours Editorial Board, eds. Digestive system tumours. WHO Classification of Tumours. 5th ed., Vol. 1. IARC;2019:104–9.

13. Massironi S., Gallo C., Elvevi A., Stegagnini M., Coltro L.A., Invernizzi P. Incidence and prevalence of gastric neuroendocrine tumors in patients with chronic atrophic autoimmune gastritis. World J Gastrointest Oncol. 2023;15(8):1451–60. DOI: 10.4251/wjgo.v15.i8.1451

14. Tsolakis A.V., Ragkousi A., Vujasinovic M., Kaltsas G., Daskalakis K. Gastric neuroendocrine neoplasms type 1: A systematic review and meta-analysis. World J Gastroenterol. 2019;25(35):5376–87. DOI: 10.3748/wjg.v25.i35.5376

15. Osmola M., Chapelle N., Vibet M.A., Bigot-Corbel E., Masson D., Hemont C., et al. Iron and vitamin B12 deficiency in patients with autoimmune gastritis and Helicobacter pylori gastritis: Results from a prospective multicenter study. Dig Dis. 2024;42(2):145–53. DOI: 10.1159/000535206

16. Cavalcoli F., Zilli A., Conte D., Massironi S. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. World J Gastroenterol. 2017;23(4):563–72. DOI: 10.3748/wjg.v23.i4.563

17. Losik Ye.A., Ivashkin V.T. Hematological manifestations of autoimmune gastritis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(1):37–43. (In Russ.). DOI: 10.22416/1382-4376-2016-26-1-37-43

18. Lahner E., Dilaghi E., Cingolani S., Pivetta G., Dottori L., Esposito G., et al. Gender-sex differences in autoimmune atrophic gastritis. Transl Res. 2022;248:1–10. DOI: 10.1016/j.trsl.2022.04.006

19. Li M., Huang Y., Liang X., Lu H. Prevalence of autoimmune gastritis worldwide: A systematic review and meta-analysis. Helicobacter. 2025;30(4):e70065. DOI: 10.1111/hel.70065

20. Tertychnyy А.S., Lapina Т.L., Nagornaya D.Р., Pachuashvili N.V., Kiryukhin А.Р., Fedorenko А.А., et al. Spectrum of chronic gastritis based on morphological examination of gastric biopsies. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(2):45–56. (In Russ.). DOI: 10.22416/1382-4376-2024-34-2-45-56

21. Carabotti M., Lahner E., Esposito G., Sacchi M.C., Severi C., Annibale B. Upper gastrointestinal symptoms in autoimmune gastritis: A cross-sectional study. Medicine (Baltimore). 2017;96(1):e5784. DOI: 10.1097/MD.0000000000005784

22. Miceli E., Lenti M.V., Padula D., Luinetti O., Vattiato C., Monti C.M., et al. Common features of patients with autoimmune atrophic gastritis. Clin Gastroenterol Hepatol. 2012;10(7):812–4. DOI: 10.1016/j.cgh.2012.02.018

23. Zinovyeva O.Ye., Yemelyanova A.Yu., Kozhev A.I., Olkhovskaya A.A., Nikolayev M.D. Neurological manifestations of vitamin B12 deficiency. Effektivnaya farmakoterapiya. 2021;17(6):22–8. (In Russ.). DOI: 10.33978/2307-3586-2021-17-6-22-28

24. Salinas M., Flores E., López-Garrigós M., Leiva-Salinas C. High frequency of anti-parietal cell antibody (APCA) and intrinsic factor blocking antibody (IFBA) in individuals with severe vitamin B 12 deficiency — an observational study in primary care patients. Clin Chem Lab Med. 2020;58(3):424–9. DOI: 10.1515/cclm-2019-0749

25. Lahner E., Norman G.L., Severi C., Encabo S., Shums Z., Vannella L., et al. Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency. Am J Gastroenterol. 2009;104(8):2071–9. DOI: 10.1038/ajg.2009.231

26. Kriķe P., Shums Z., Poļaka I., Kikuste I., Vanags A., Tolmanis I., et al. The diagnostic value of anti-parietal cell and intrinsic factor antibodies, pepsinogens, and gastrin-17 in corpus-restricted atrophic gastritis. Diagnostics (Basel). 2022;12(11):2784. DOI: 10.3390/diagnostics12112784

27. Shah S.C., Piazuelo M.B., Kuipers E.J., Li D. AGA Clinical Practice Update on the diagnosis and management of atrophic gastritis: Expert review. Gastroenterology. 2021;161(4):1325–32.e7. DOI: 10.1053/j.gastro.2021.06.078

28. Livzan M.A., Gaus O.V., Mozgovoi S.I., Bordin D.S. Chronic autoimmune gastritis: Modern diagnostic principles. Diagnostics (Basel). 2021;11(11):2113. DOI: 10.3390/diagnostics11112113

29. Chapelle N., Martin J., Osmola M., Hémont C., Leroy M., Vibet M.A., et al. Serum pepsinogens can help to discriminate between H. pylori-induced and auto-immune atrophic gastritis: Results from a prospective multicenter study. Dig Liver Dis. 2023;55(10):1345–51. DOI: 10.1016/j.dld.2023.03.015

30. Chebotareva M.V., Nikolskaya K.A., Andreev D.N., Dorofeev A.S., Khomeriki S.G., Tsapkova L.A., et al. Serological markers as predictors of the severity of gastric mucosal atrophy in autoimmune and Helicobacter рylori-associated gastritis. Terapevticheskii arkhiv. 2025;97(8):651–9. DOI: 10. 26442/00403660.2025.08.203343

31. Xiang L., Zhou Y., Guo X., Mommersteeg M.C., Nieuwenburg S.A.V., Peppelenbosch M.P., et al. Evaluation of pepsinogen I, II, gastrin 17 and Helicobacter pylori IgG in atrophic gastritis: A head-to-head comparison of lateral flow and enzyme-linked immunosorbent assays. Helicobacter. 2025;30(4):e70066. DOI: 10.1111/hel.70066

32. Herold Z., Herold M., Nagy P., Patocs A., Doleschall M., Somogyi A. Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin-like cell hyperplasia and autoimmune gastritis. J Diabetes Investig. 2020;11(4):865–73. DOI: 10.1111/jdi.13203

33. Massironi S., Gallo C., Elvevi A., Stegagnini M., Coltro L.A., Invernizzi P. Incidence and prevalence of gastric neuroendocrine tumors in patients with chronic atrophic autoimmune gastritis. World J Gastrointest Oncol. 2023;15(8):1451–60. DOI: 10.4251/wjgo.v15.i8.1451

34. Terao S., Suzuki S., Yaita H., Kurahara K., Shunto J., Furuta T., et al. Multicenter study of autoimmune gastritis in Japan: Clinical and endoscopic characteristics. Dig Endosc. 2020;32(3):364–72. DOI: 10.1111/den.13500

35. Kamada T., Watanabe H., Furuta T., Terao S., Maruyama Y., Kawachi H., et al. Diagnostic criteria and endoscopic and histological findings of autoimmune gastritis in Japan. J Gastroenterol. 2023;58(3):185–95. DOI: 10.1007/s00535-022-01954-9

36. Kishino M., Nonaka K. Endoscopic features of autoimmune gastritis: Focus on typical images and early images. J Clin Med. 2022;11(12):3523. DOI: 10.3390/jcm11123523

37. Dilaghi E., Esposito G., Pivetta G., Galli G., Pilozzi E., Annibale B., Lahner E. Endoscopic diagnosis of gastric intestinal metaplasia in patients with autoimmune gastritis using narrow-band imaging: Does pseudopyloric metaplasia muddy the waters? Endosc Int Open. 2022;10(4):E434– 40. DOI: 10.1055/a-1776-7628

38. Kotera T., Ayaki M., Sumi N., Aoki R., Mabe K., Inoue K., et al. Characteristic endoscopic findings in early-stage autoimmune gastritis. Endosc Int Open. 2024;12(3):E332–8. DOI: 10.1055/a-2215-3284

39. Drapkina O.M., Kashin S.V., Kuvaev R.O., Kaibysheva V.O., Krainova E.A., Shepel R.N., et al. Modern algorithm of diagnostics and management of patients with chronic atrophic gastritis and intestinal metaplasia of the stomach. The Russian Journal of Preventive medicine. 2023;26(1):7–10. (In Russ.). DOI: 10.17116/profmed2023260117

40. Kuvaev R., Kashin S., Kraynova E. A new indicator for autoimmune gastritis by magnifying image enhanced endoscopy: “Glomus like” lesions of the gastric corpus. Dig Endosc. 2022;34(Suppl 1):52.

41. Kuvaev R.O., Kashin S.V., Kraynova E.A., Chamorovskaya A.B. “Glomus-like lesions” of the gastric fundic type mucosa — a novel endoscopic sign of autoimmune atrophic gastritis. Russian Journal of Evidence-Based Gastroenterology. 2025;14(4):66–75. (In Russ.). DOI: 10.17116/dokgastro20251404166

42. Tertychnyy A.S., Pachuashvili N.V., Protsenko D.D., Nagornaya D.P., Kazumova A.B. Morphological characteristics of autoimmune gastritis. Russian Journal of Archive of Pathology. 2024;86(6):15–20. (In Russ.). DOI: 10.17116/patol20248606115

43. Best L.M., Takwoingi Y., Siddique S., Selladurai A., Gandhi A., Low B., et al. Non-invasive diagnostic tests for Helicobacter pylori infection. Cochrane Database Syst Rev. 2018;3(3):CD012080. DOI: 10.1002/14651858.CD012080.pub2

44. Abd Rahim M.A., Johani F.H., Shah S.A., Hassan M.R., Abdul Manaf M.R. 13C-urea breath test accuracy for Helicobacter pylori infection in the Asian population: A meta-analysis. Ann Glob Health. 2019;85(1):110. DOI: 10.5334/aogh.2570

45. Shin C.M., Kim N., Lee H.S., Lee H.E., Lee S.H., Park Y.S., et al. Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/ or intestinal metaplasia. Helicobacter. 2009;14(6):512–9. DOI: 10.1111/j.1523-5378.2009.00726.x

46. Cellini M., Santaguida M.G., Virili C., Capriello S., Brusca N., Gargano L., et al. Hashimoto’s thyroiditis and autoimmune gastritis. Front Endocrinol (Lausanne). 2017;8:92. DOI: 10.3389/fendo.2017.00092

47. Benites-Zapata V.A., Ignacio-Cconchoy F.L., UlloqueBadaracco J.R., Hernandez-Bustamante E.A., AlarcónBraga E.A., Al-Kassab-Córdova A., et al. Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1070592. DOI: 10.3389/fendo.2023.1070592

48. Pan X.F., Gu J.Q., Shan Z.Y. Type 1 diabetic populations have an increased prevalence of parietal cell antibody: A systematic review and meta-analysis. Medicine (Baltimore). 2015;94(38):e1440. DOI: 10.1097/MD.0000000000001440

49. Müller H., Rappel S., Wündisch T., Bayerdörffer E., Stolte M. Healing of active, non-atrophic autoimmune gastritis by H. pylori eradication. Digestion. 2001;64(1):30– 9. DOI: 10.1159/000048836

50. Kotera T., Nishimi Y., Kushima R., Haruma K. Regression of autoimmune gastritis after eradication of Helicobacter pylori. Case Rep Gastroenterol. 2023;17(1):34–40. DOI: 10.1159/000528388

51. Lee J.S., Jeon S.W., Lee H.S., Kwon Y.H., Nam S.Y., Bae H.I., et al. Rebamipide for the improvement of gastric atrophy and intestinal metaplasia: A prospective, randomized, pilot study. Dig Dis Sci. 2022;67(6):2395–402. DOI: 10.1007/s10620-021-07038-7

52. Bakulin I.G., Sushilova A.G., Zharkov A.V., Malkov V.A. Effectiveness of 6-month rebamipide therapy in chronic atrophic gastritis: Results of the OPLOT study. Effektivnaya farmakoterapiya. 2024;20(46):28–34. (In Russ.). DOI: 10.33978/2307-3586-2024-20-46-28-34

53. Bakulin I.G., Sushilova A.G., Zharkov A.V. Rebamipide efficacy in chronic atrophic gastritis (OPLOT study results). Russian Medical Inquiry. 2025;9(9):580–6. (In Russ.). DOI: 10.32364/2587-6821-2025-9-9-7

54. Calabrese F., Pasta A., Bodini G., Furnari M., Grillo F., Mastracci L., et al. Autoimmune chronic atrophic gastritis: Association between chronic proton pump inhibitors use and more severe atrophy and gastric intestinal metaplasia. Eur J Gastroenterol Hepatol. 2025;37(8):905–10. DOI: 10.1097/MEG.0000000000002989

55. Dilaghi E., Bellisario M., Esposito G., Carabotti M., Annibale B., Lahner E. The impact of proton pump inhibitors on the development of gastric neoplastic lesions in patients with autoimmune atrophic gastritis. Front Immunol. 2022;13:910077. DOI: 10.3389/fimmu.2022.910077

56. Drapkina O.M., Ivashkin V.T., Maev I.V., Livzan M.A., Abdulganieva D.I., Bakulin I.G., et al. Follow-up monitoring of patients with gastritis and duodenitis by a primary care physician. Guidelines. Primary Health Care (Russian Federation). 2025;2(3):263–80. (In Russ.). DOI: 10.15829/3034-4123-2025-67

57. Angerilli V., Vanoli A., Celin G., Ceccon C., Gasparello J., Sabbadin M., et al. Gastric carcinoma in autoimmune gastritis: A histopathologic and molecular study. Mod Pathol. 2024;37(6):100491. DOI: 10.1016/j.modpat.2024.100491

58. Kishikawa H., Takarabe S., Ichikawa M., Sasaki A., Nishida J. Gastric adenocarcinoma in Helicobacter pylori-negative autoimmune gastritis: A case report and literature review. Cureus. 2024;16(8):e66910. DOI: 10.7759/cureus.66910

59. Vannella L., Lahner E., Osborn J., Annibale B. Systematic review: Gastric cancer incidence in pernicious anaemia. Aliment Pharmacol Ther. 2013;37(4):375–82. DOI: 10.1111/apt.12177

60. Mahmud N., Stashek K., Katona B.W., Tondon R., Shroff S.G., Roses R., et al. The incidence of neoplasia in patients with autoimmune metaplastic atrophic gastritis: A renewed call for surveillance. Ann Gastroenterol. 2019;32(1):67–72. DOI: 10.20524/aog.2018.0325


Review

For citations:

Ivashkin V.T., Maev I.V., Lapina T.L., Trukhmanov A.S., Rumyantseva D.E., Storonova O.A., Paraskevova A.V., Tertychnyy A.S., Kiryukhin A.P., Pavlov P.V., Abdulkhakov S.R., Alekseeva O.P., Alekseenko S.A., Andreev D.N., Bakulin I.G., Bakulina N.V., Bordin D.S., Galeeva Z.M., Dekhnich N.N., Kononov A.V., Korochanskaya N.V., Kuvaev R.O., Kucheryavyy Yu.A., Livzan M.A., Osipenko M.F., Pirogov S.S., Sarsenbaeva A.S., Simanenkov V.I., Troshina E.A., Fedorov E.D., Khlynov I.B., Tsukanov V.V. Clinical Recommendations of the Russian Gastroenterological Association for the Diagnosis and Treatment of Autoimmune Gastritis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2025;35(6):115-135. https://doi.org/10.22416/1382-4376-2025-35-6-115-136

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ISSN 1382-4376 (Print)
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Tatiana L. Lapina - MD, PhD, associate professor, Department of Internal Diseases Propedeutics,
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
119146,  Moscow, PO box 31
e-mail: editorial@gastro-j.ru, tatlapina@gmail.com
tel.: +79031926919

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