Современные возможности применения рифаксимина в гастроэнтерологии
Аннотация
Цель обзора. Показать особенности фармакокинетики и фармакодинамики, а также возможности клинического применения невсасывающегося антибиотика рифаксимина.
Последние данные литературы Невсасывающийся антибиотик рифаксимин обладает целым рядом преимуществ в отношении фармакокинетики и фармакодинамики по сравнению с системно действующими антибиотиками. В настоящее время очерчен круг гастроэнтерологических заболеваний, при которых эффективность рифаксимина может считаться доказанной. К ним относятся: инфекционная диарея (включая диарею путешественников), синдром избыточного роста бактерий, дивертикулярная болезнь кишечника, хронические воспалительные заболевания кишечника, печеночная энцефалопатия. Этот круг может быть расширен после проведения дополнительных клинических исследований возможности применения рифаксимина и при других заболеваниях (например, диарее, обусловленной Cl. difficile, функциональных расстройствах кишечника, для эрадикации инфекции H. pylori и др.).
Заключение. АльфаНормикс (рифаксимин) является высокоэффективным и безопасным невсасывающимся антибиотиком, который может найти широкое применение при лечении различных гастроэнтерологических заболеваний.
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Рецензия
Для цитирования:
Шептулин А.А., Торрес Э.А. Современные возможности применения рифаксимина в гастроэнтерологии. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2008;18(5):17-22.
For citation:
Sheptulin A.A., Torres E.A. Rifaximin in gastroenterology: state-of-the-art. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(5):17-22. (In Russ.)
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