Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma
https://doi.org/10.22416/1382-4376-2019-29-2-53-59
Abstract
Aim. Tostudy the content and profile of short-chain fatty acids (SCFAs) in faeces of patients with bronchial asthma and healthy individuals, as well as to evaluate possible correlations between the SCFA spectrum and clinical phenotype of patients with bronchial asthma.
Materials and methods. 44 patients with asthma and 17 healthy volunteers participated in the study. All participants underwent a generally accepted range of clinical and laboratory studies, as well as functional respiratory tests. The SCFA spectrum was determined using gas-liquid chromatographic analysis. The results of patients with asthma showed a significant decrease in the total fatty acid content in faeces (p <0.001); changes in the absolute concentrations of individual acids, such as acetate (p <0.001), propionate (p <0.001) and butyrate (p <0.001); as well as a change in the total isoacid content (p <0.001). In 83% of the cases, the anaerobic type of the SCFA spectrum was detected. The aerobic type of the SCFA metabolic profile was detected in 17% of the cases. The change in the metabolic profile did not depend on the phenotype of the disease.
Conclusion. Changes in SCFAs indicate pronounced disorders in the microbiocenosis of the intestinal biotope. The values of the anaerobic index in the context of various changes in the acid metabolic profile indicate the disturbance of the microorganism’s habitat, contributing to the growth of anaerobic or aerobic microflora populations.
About the Authors
O. Yu. Zolnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Internal Diseases, Medical Faculty
Russian Federation
Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Internal Diseases, Medical Faculty
N. D. Potskhverashvili
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Doctor, Pulmonology Department, V.H. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology
Russian Federation
Doctor, Pulmonology Department, V.H. Vasilenko Clinic of Internal Diseases Propaedeutics, Gastroenterology and Hepatology
N. I. Kokina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Internal Diseases, Medical Faculty; Departmental Head, Pulmonology Department, V.H. Vasilenko Clinic of Internal Diseases, Propedeutics, Gastroenterology and Hepatology
Russian Federation
Cand. Sci. (Med.), Associate Professor, Department of Propaedeutics of Internal Diseases, Medical Faculty; Departmental Head, Pulmonology Department, V.H. Vasilenko Clinic of Internal Diseases, Propedeutics, Gastroenterology and Hepatology
A. S. Trukhmanov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Dr. Sci. (Med.), Prof., Department of Propaedeutics of Internal Diseases, Medical Faculty
Russian Federation
Dr. Sci. (Med.), Prof., Department of Propaedeutics of Internal Diseases, Medical Faculty
V. T. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Dr. Sci. (Med.), RAS Academician, Prof., Departmental Head, Department of Propaedeutics of Internal Diseases, Medical Faculty; Director, V.H. Vasilenko Clinic of Internal Diseases, Propedeutics, Gastroenterology and Hepatology
Russian Federation
Dr. Sci. (Med.), RAS Academician, Prof., Departmental Head, Department of Propaedeutics of Internal Diseases, Medical Faculty; Director, V.H. Vasilenko Clinic of Internal Diseases, Propedeutics, Gastroenterology and Hepatology
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Review
For citations:
Zolnikova O.Yu., Potskhverashvili N.D., Kokina N.I., Trukhmanov A.S., Ivashkin V.T. Intestinal Short-Chain Fatty Acids in Patients with Bronchial Asthma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(2):53-59. (In Russ.) https://doi.org/10.22416/1382-4376-2019-29-2-53-59
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