Probiotics in the Modern World
https://doi.org/10.22416/1382-4376-2020-30-3-24-35
Abstract
Aim of review. The review highlights modern concepts of the role of microbiome in sustaining the human body, the place of probiotics in treatment and prevention of pathologies related to disorders in healthy microbiota.
Key points. Microbiome is a unique panorganismal system normally maintaining self-equilibrium and possessing a vast and diverse functionality. Imbalance in normal microbiota can be assisted by probiotics, i.e. living microorganisms that sustain health of the host when being supplied in adequate amounts. Alike normal microflora, probiotic strains incorporate into general metabolism by mediating a spectrum of functions, e.g. maintaining colonisation resistance, nutrient metabolism, supplying the host with vital metabolites, regulation of local and adaptive immune responses, enhancing the intestinal barrier. Probiotics are applied in various diseases associated with general imbalances of the organism. Modern probiotic preparations are characterised by acid- and antibiotic-resistivity and safety, thus being suitable for treating gut microbiome-associated disorders in various age groups.
Conclusion. Probiotic strains, as well as medications designed on their basis, are widely applied and show good promise. Further research into their properties will advance the prospects of probiotic treatment.
About the Authors
Y. P. Uspenskiy
St. Petersburg State Pediatric Medical University; Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Yuriy P. Uspenskiy — Dr. Sci. (Med.), Prof., Head of the Department of Faculty Therapy named after Prof. V.A. Valdman; Prof., Department of Internal Diseases, Faculty of Dentistry
SPIN: 7306-1228
194100, St. Petersburg, Litovskaya str., 2.
Y. A. Fominykh
Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Yuliya A. Fominykh — Cand. Sci. (Med.), Assoc. Prof., Department of Internal Diseases, Faculty of Dentistry
SPIN: 3758-9875
197022, St. Petersburg, Lva Tolstogo str., 6/8.
K. N. Nadzhafova
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Kyamalya N. Nadzhafova — Senior Medical Laboratory Assistant, Department of Faculty Therapy named after Prof. V.A. Valdman
SPIN: 4547-2436
194100, St. Petersburg, Litovskaya str., 2.
S. V. Polyushkin
Rehabilitation Center
Russian Federation
Russian Federation
Sergey V. Polyushkin — Cand. Sci. (Med.), head physician
143088, Moscow region, Odintsovo district, A.I. Herzen sanatorium settlement, Rehabilitation Center.
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For citations:
Uspenskiy Y.P., Fominykh Y.A., Nadzhafova K.N., Polyushkin S.V. Probiotics in the Modern World. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(3):24-35. (In Russ.) https://doi.org/10.22416/1382-4376-2020-30-3-24-35
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