Mutual Effect of NAT2 rs1799930 (590G>A) Polymorphism and Alcohol Abuse on Risk of Acute Pancreatitis
https://doi.org/10.22416/1382-4376-2020-30-6-40-44
Abstract
Aim. Estimation of the contribution of rs1799930 (590G>A) polymorphism of gene NAT2 to the development of acute alcoholic pancreatitis.
Materials and methods. DNA samples were obtained from 547 unrelated patients with acute alcoholic pancreatitis and 573 unrelated individuals without gastrointestinal diseases. A survey selected individuals with the alcohol consumption of >200 g/week pure ethanol two times a week or more during 10 or more years. Genotyping was performed with PCR using TaqMan allelic discrimination assays.
Results. No association was observed between the NAT2 allelic rs1799930 (590G>A) polymorphism, risk of acute alcoholic pancreatitis, duration and rate of alcohol consumption. The 590G>A variant of rs1799930 in gene NAT2 correlated with an increased risk of acute alcoholic pancreatitis (odds ratio 2.16; 95% confidence interval 1.13–4.12) under alcohol consumption >200 g/week pure ethanol.
Conclusion. The rs1799930 G/A polymorphism of gene NAT2 increases the risk of acute pancreatitis under alcohol consumption >200 g/week pure ethanol.
About the Author
T. A. Samgina
Kursk State Medical University
Russian Federation
Russian Federation
Tatyana A. Samgina — Cand. Sci. (Med.), Assoc. Prof., Department of Surgical Diseases No. 2
305000, Kursk, Karla Marksa str., 3
References
1. Setiawan V.W., Pandol S.J., Porcel J., Wilkens L.R., Le Marchand L., Pike M.C., Monroe K.R. Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas. 2016;45(6):819–25. DOI: 10.1097/MPA.0000000000000657
2. Ahmed Ali U., Issa Y., Hagenaars J.C., Bakker O.J., van Goor H., Nieuwenhuijs V.B., et al. Risk of recurrent pancreatitis and progression to chronic pancreatitis after a first episode of acute pancreatitis. Clin Gastroenterol Hepatol. 2016;14(5):738–46. DOI: 10.1016/j.cgh.2015.12.040
3. Blum M., Grant D.M., McBride W., Heim M., Meyer U.A. Human arylamine-N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell Biol. 1990;9(3):193–203. DOI: 10.1089/dna.1990.9.193
4. Sabbagh A., Darlu P., Crouau-Roy B., Poloni E.S. Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. PloS One. 2011;6(4):е18507. DOI: 10.1371/journal.pone.0018507
5. Hein D.W., Grant D.M., Sim E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics. 2000;10(4):291–2. DOI: 10.1097/00008571200006000-00002
6. Tian F.S., Shen L., Ren Y.W., Zhang Y. N-acetyltransferase 2 gene polymorphisms are associated with susceptibility to cancer: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(14):5621–6. DOI: 10.7314/apjcp.2014.15.14.5621
7. Jang J.H., Cotterchio M., Borgida A., Gallinger S. Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk. Carcinogenesis. 2012;33(4):818–27. DOI: 10.1093/carcin/bgs028
8. Whitcomb D.C., Yadav D., Adam S., Hawes R.H. Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2). Pancreatology. 2008;8(4–5):520–31. DOI: 10.1159/000152001
9. McNally P.R. Secrets of gastroenterology. Moscow: Binom; 2001 (In Russ.).
10. Furtwaengler N.A., de Visser R.O. Lack of international consensus in low-risk drinking guidelines. Drug Alcohol Rev. 2013;32(1):11–8. DOI: 10.1111/j.14653362.2012.00475.x
11. Forsmark C.E., Baillie J.; AGA Institute Clinical Practice and Economics Committee; AGA Institute Governing Board. AGA Institute Technical Review on Acute Pancreatitis. Gastroenterol. 132(5):2022–44. DOI: 10.1053/j.gastro.2007.03.065
12. Somogyi L., Martin S.P., Venkatesan T., Ulrich C.D. Recurrent acute pancreatitis: an algorithmic approach to identification and elimination of inciting factors. Gastroenterology. 2001;120(3):708–17. DOI: 10.1053/gast.2001.22333
13. Weiss F.U., Laemmerhirt F., Lerch M.M. Etiology and risk factors of acute and chronic pancreatitis. Visc Med. 2019;35(2):73–81. DOI: 10.1159/000499138
14. Polonikov A.V., Samgina T.A., Nazarenko P.M., Bushueva O.Y. Alcohol consumption and cigarette smoking are important modifiers of the association between acute pancreatitis and the PRSS1-PRSS2 locus in men. Pancreas. 2017;46(2):230–6. DOI: 10.1097/MPA.0000000000000729
15. Geller F., Soborg B., Koch A., Michelsen S.W. Determination of NAT2 acetylation status in the Greenlandic population. Arch Toxicol. 2016;90:883–9. DOI: 10.1007/s00204-015-1501-1
16. Yarosh S.L., Kokhtenko E.V., Churnosov M.I., Ataman A.V., Solodilova M.A., Polonikov A.V. Synergism between the N-acetyltransferase 2 gene and oxidant exposure increases the risk of idiopathic male infertility. Reprod Biomed Online. 2014;29(3):362–9. DOI: 10.1016/j.rbmo.2014.04.008
17. Adithan C., Subathra A. NAT2 gene polymorphism: covert drug interaction causing phenytoin toxicity. Indian J Med Res. 2016;143(5):542–4. DOI: 10.4103/0971-5916.187101
18. Sun J.D., Yuan H., Hu H.Q., Yu H.M. Association of Nacetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population. Genet Mol Res. 2016;15(1):15016954. DOI: 10.4238/gmr.15016954
19. Kukes V.G. Drug metabolism: clinical and pharmacological aspects. Moscow: Reafarm; 2004 (In Russ.).
20. Kasajova P., Holubekova V., Mendelova A., Lasabova Z., Zubor P., Kudela E. Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms. Tumor Biology. 2016;37(6):7929–37. DOI: 10.1007/s13277-0154685-3
21. Tian F., Zhang Y., Ren Y., Shen L. N-Acetyltransferase 2 (NAT2) gene polymorphism and exposure to smoking in lung cancer of Chinese males. Medical Oncology. 2014:31(8):90. DOI: 10.1007/s12032-014-0090-9
22. Zou Y., Dong S., Xu S., Gong Q., Chen J. Genetic polymorphisms of NAT2 and risk of acute myeloid leukemia: A case-control study. Medicine (Baltimore). 2017;96(42):7499. DOI: 10.1097/MD.0000000000007499
Review
For citations:
Samgina T.A. Mutual Effect of NAT2 rs1799930 (590G>A) Polymorphism and Alcohol Abuse on Risk of Acute Pancreatitis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(6):40-44. (In Russ.) https://doi.org/10.22416/1382-4376-2020-30-6-40-44
Views:
696
Email this article 
