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Российский журнал гастроэнтерологии, гепатологии, колопроктологии

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Методы оценки кишечной проницаемости: обзор литературы

https://doi.org/10.22416/1382-4376-2021-31-1-20-30

Полный текст:

Аннотация

Цель обзора: проанализировать данные по методам оценки кишечной проницаемости.

Основные положения. Кишечный барьер представляет собой функциональное образование, разделяющее просвет кишечника и внутреннюю среду организма, кишечная проницаемость позволяет оценивать функционирование кишечного барьера. Методы, используемые для оценки проницаемости и целостности кишечного барьера, различаются в зависимости от условий их применения (in vivo или ex vivo), объекта исследования (человек или животные), маркерных молекул, используемых для оценки проницаемости (ионы, углеводы различных размеров, макромолекулы и антигены, бактериальные продукты и бактерии), а также биоматериалов, используемых для измерения концентрации маркерных молекул (периферическая кровь, кровь из воротной вены, моча, кал). Несмотря на большое разнообразие методов оценки кишечной проницаемости, их применение в клинической практике требует дальнейшего изучения ввиду отсутствия их стандартизации, сложности проведения некоторых методик и порой недостаточно высокой достоверности результатов.

Заключение. Необходимо дальнейшее изучение и усовершенствование методов оценки кишечной проницаемости. Стандартизация методик и их результатов обеспечит возможность внедрения в практику при функциональных и органических заболеваниях кишечника, а также при аллергических заболеваниях, сахарном диабете, неалкогольной жировой болезни печени и ряде других заболеваний.

Об авторах

А. А. Якупова
Казанский (Приволжский) федеральный университет
Россия

Якупова Алина Айратовна — врач-ординатор кафедры фундаментальных основ клинической медицины.

420012, Казань, ул. Карла Маркса, д. 76.



С. Р. Абдулхаков
Казанский (Приволжский) федеральный университет; Казанский государственный медицинский университет Министерства здравоохранения Российской Федерации
Россия

Абдулхаков Сайяр Рустамович — кандидат медицинских наук, заведующий кафедрой фундаментальных основ клинической медицины КФУ; доцент кафедры поликлинической терапии и общей врачебной практики КГМУ МЗ РФ.

420012, Казань, ул. Карла Маркса, д. 76.



Р. К. Залялов
Казанский (Приволжский) федеральный университет, Медико-санитарная часть
Россия

Залялов Рамиль Камилевич — врач-эндоскопист.

420043, Казань, ул. Чехова, д. 1а.



А. Г. Сафин
Казанский (Приволжский) федеральный университет, Медико-санитарная часть
Россия

Сафин Айрат Габбасович — врач-эндоскопист, заведующий эндоскопическим отделением.

420043, Казань, Чехова, д. 1а.



Р. А. Абдулхаков
Казанский государственный медицинский университет» Министерства здравоохранения Российской Федерации
Россия

Абдулхаков Рустам Аббасович — доктор медицинских наук, профессор, профессор кафедры госпитальной терапии.

420012, Казань, ул. Бутлерова, д. 49.



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Якупова А.А., Абдулхаков С.Р., Залялов Р.К., Сафин А.Г., Абдулхаков Р.А. Методы оценки кишечной проницаемости: обзор литературы. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(1):20-30. https://doi.org/10.22416/1382-4376-2021-31-1-20-30

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Iakupova A.A., Abdulkhakov S.R., Zalyalov R.K., Safin A.G., Abdulkhakov R.A. Intestinal Permeability Assays: a Review. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(1):20-30. (In Russ.) https://doi.org/10.22416/1382-4376-2021-31-1-20-30

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