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Российский журнал гастроэнтерологии, гепатологии, колопроктологии

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Фармакотерапия фиброза печени в исходе неалкогольного стеатогепатита

https://doi.org/10.22416/1382-4376-2021-31-5-16-24

Аннотация

Цель обзора: описать современное состояние проблемы фармакотерапии ассоциированного с неалкогольным стеатогепатитом (НАСГ) фиброза печени.

Основные положения. В соответствии с текущими клиническими рекомендациями лечебные мероприятия при неалкогольной жировой болезни печени должны заключаться в изменении образа жизни, нормализации массы тела, специфической фармакотерапии ассоциированного с НАСГ фиброза печени и лечении связанных с метаболическим синдромом заболеваний. Несмотря на отсутствие утвержденных схем антифибротической терапии при НАСГ, существует ряд препаратов, которые в клинических испытаниях фазы 3 продемонстрировали адекватный профиль эффективности и безопасности у разных больных, включая пациентов с компенсированным циррозом печени. Это позволяет одобрить их для проверки и подтверждения практической пользы в клинических испытаниях фазы 4.

Заключение. Учитывая, что развитие фиброза печени является неблагоприятным событием естественного течения неалкогольной жировой болезни печени, очевидно, что скорейшее внедрение и широкое применение методов антифибротической терапии улучшит результаты лечения НАСГ и позволит избежать связанных с ним осложнений.

Об авторе

Д. В. Гарбузенко
ГБОУ ВПО «Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации
Россия

Гарбузенко Дмитрий Викторович — доктор медицинских наук, профессор кафедры факультетской хирургии

454092, г. Челябинск, ул. Воровского, д. 64



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Рецензия

Для цитирования:


Гарбузенко Д.В. Фармакотерапия фиброза печени в исходе неалкогольного стеатогепатита. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(5):16-24. https://doi.org/10.22416/1382-4376-2021-31-5-16-24

For citation:


Garbuzenko D.V. Drug Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Fibrosis. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(5):16-24. (In Russ.) https://doi.org/10.22416/1382-4376-2021-31-5-16-24

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