Treatment of Functional Dyspepsia in Outpatients after COVID-19 Infection
https://doi.org/10.22416/1382-4376-2022-32-6-47-52
Abstract
Aim: to compare the efficacy of different therapeutic regimens for managing functional dyspepsia in outpatients after COVID-19 infection.
Materials and methods. 42 post-COVID-19 outpatients (age: 26–47 years) diagnosed with functional dyspepsia (FD) according to the Rome IV Criteria were enrolled in two parallel groups. All patients were divided in 2 groups by randomization: Group 1 received omeprazole at a dose of 80 mg/day, Group 2 received a combination of omeprazole and Kolofort® (a combined action drug product containing technologically processed antibodies to S100, TNF-alpha, and histamine) at a dose of 80 mg/day. At baseline and after treatment, a 10-point VAS was used to measure symptoms and an SF-36 questionnaire to evaluate the quality of life.
Results. By Day 28 of the treatment, the intensity of epigastric pain (VAS score) in the group receiving proton-pump inhibitor (PPI) + Kolofort® was significantly lower. In both groups, fully resolved dyspeptic syndrome was observed in up to 90 % of patients, without significant differences (p < 0.06). According to the SF-36 data, a combination treatment resulted in higher scores (pain and general health subscales) as compared to the PPI alone.
Conclusion. Kolofort® relieves symptoms and improves the quality of life when added to the treatment regimen against functional dyspepsia in post-COVID-19 patients.
Supporting agencies: The publication was supported by “Materia Medica”.
About the Authors
M. S. Turchina
I.S. Turgenev Oryol State University
Russian Federation
Russian Federation
Maria S. Turchina — Cand. Sci. (Med.), Assistant Professor, Department of Internal Diseases, gastroenterologist, Polyclinic No. 3 of Oryol Region; I.S. Turgenev Oryol State University.
302026 Oryol, Komsomolskaya str., 95
Yu. M. Morozov
I.S. Turgenev Oryol State University
Russian Federation
Russian Federation
Yury M. Morozov — Dr. Sci. (Med.), Chair of the Department of Specialized Surgical Disciplines, I.S. Turgenev Oryol State University.
302026 Oryol, Komsomolskaya str., 95
T. I. Obolenskaya
I.S. Turgenev Oryol State University
Russian Federation
Russian Federation
Tatyana I. Obolenskaya — Cand. Sci. (Med.), Assistant Professor, Department of Immunology and Specialized Clinical Disciplines, I.S. Turgenev Oryol State University.
302026 Oryol, Komsomolskaya str., 95
References
1. Ivashkin V.T., Maev I.V., Sheptulin A.A., Lapina T.L., Trukhmanov A.S., Kartavenko I.M., et al. Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(1):50-61 (In Russ.). DOI: 10.22416/1382-4376-2017-27-1-50-61
2. Lyalyukova E.A., Batishcheva G.A., Vize-Khripunova M.A., Lapina E.D. Lyalyukova A.S. et al. Dyspepsia syndrome in a primary care setting: clinical options and patient management. Challenging case. 2019;6-7(17):38-46 (In Russ.). DOI: 10.24411/2074-1995-2019-10051
3. Osadchuk M.A., Svistunov A.A., Balashov D.V., Osadchuk M.M. Functional dyspepsia: a many-sided challenge in gastroenterology. Therapeutic archive. 2021;93(12):1539-44 (In Russ.).
4. Uspensky Yu.P., Mirzoev O.S., Fominykh Yu.A., Gnutov A.A., Polyushkin S.V. Therapeutic potential in a mixed functional gastrointestinal disorder: outcomes of an open-label study. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2020;30(5):30-41 (In Russ.). DOI: 10.22416/1382-4376-2020-30-5-30-41
5. Pakhomova I.G. A patient with dyspepsia after COVID-19 infection at visit. Possible ways to solve the problem. Challenging case. 2021;2(19):46-50 (In Russ.).
6. Sheptulin A.A., Pyatenko E.A. Functional gastrointestinal disorders during the COVID-19 pandemic. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(3):52-6 (In Russ.). DOI: 10.22416/1382-4376-2022-32-3-52-56
7. Nakov R., Dimitrova-Yurukova D., Snegarova V., Nakov V., Fox M., Heinrich H. Increased prevalence of gastrointestinal symptoms and disorders of gut-brain interaction during the COVID-19 pandemic: An internet-based survey. Neurogastroenterol Motil. 2022;34(2):e14197. DOI: 10.1111/nmo.14197
8. Saidov S.S., Smetneva N.S., Davydova S.S., Kalinina N.N., Chekalnikov D.A. Prevalence of gastrointestinal symptoms among clinical manifestations of COVID-19. Bulletin of the Medical Institute “REAVIZ”. 2021;3:5-12 (In Russ.). DOI: 10.20340/vmi-rvz.2021.3.COVID.1
9. Blackett J.W., Li J., Jodorkovsky D., Freedberg D.E. Prevalence and risk factors for gastrointestinal symptoms after recovery from COVID-19 Neurogastroenterol Motil. 2021;e14251. DOI: 10.1111/nmo.14251
10. Ghoshal U.C., Ghoshal U., Rahman M.M., Mathur A., Rai S., Akhter M., et al. Post-infection functional gastrointestinal disorders following coronavirus disease-19: A casecontrol study. J Gastroenterol Hepatol. 2021;10.1111/ jgh.15717. DOI: 10.1111/jgh.15717
11. Noviello D., Costantino A., Muscatello A., Bandera A., Consonni D., Vecchi M., et al. Functional gastrointestinal and somatoform symptoms five months after SARS-CoV-2 infection: A controlled cohort study. Neurogastroenterol Motil. 2022;34(2):e14187. DOI: 10.1111/nmo.14187
12. Velez C., Paz M., Silvernale C., Stratton L.W., Kuo B., Staller K., et al. Factors associated with chronic de novo post-coronavirus disease gastrointestinal disorders in a metropolitan US county. Clin Gastroenterol Hepatol. 2021;S1542-3565(21)01133-2. DOI: 10.1016/j.cgh.2021.10.020
13. Sayuk G.S., Gyawali C.P. Functional Dyspepsia: Diagnostic and Therapeutic Approaches. Drugs. 2020;80(13):1319-36. DOI: 10.1007/s40265-020-01362-4
14. Yamawaki H., Futagami S., Wakabayashi M., Sakasegawa N., Agawa S., Higuchi K., et al. Management of functional dyspepsia: state of the art and emerging therapies. Ther Adv Chronic Dis. 2018;9(1):23-32. DOI: 10.1177/2040622317725479
15. Oshima T., Siah K.T.H.., Yoshimoto T., Miura K., Toshohiko T., Fukui H., et al. Impacts of the COVID-19 pandemic on functional dyspepsia and irritable bowel syndrome: A population-based survey. J Gastroenterol Hepatol. 2021;36(7):1820-7. DOI: 10.1111/jgh.15346
Review
For citations:
Turchina M.S., Morozov Yu.M., Obolenskaya T.I. Treatment of Functional Dyspepsia in Outpatients after COVID-19 Infection. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(6):47-52. https://doi.org/10.22416/1382-4376-2022-32-6-47-52
Views:
451
Email this article 
