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A Woman with a Long History of Smoking and a Debilitating Dry Cough

https://doi.org/10.22416/1382-4376-2024-34-3-99-106

Abstract

Aim: to present a clinical case of colorectal cancer in a woman with a long history of smoking and a leading complaint of dry cough.

Key points. A 56-year-old patient with a long history of smoking was hospitalized in the pulmonology department of the clinic with a leading complaint of a constant debilitating dry cough during the day, not amenable to the action of drugs, as well as general weakness, sweating and weight loss by 2 kg in 3 months. The examination revealed a moderately differentiated adenocarcinoma of the hepatic bend of the colon with generalized lymphadenopathy and metastatic lung damage, iron deficiency anemia. Surgical treatment was performed at the Sechenov University surgical hospital: right-sided hemicolectomy with D2 lymph dissection (removal of epicolic, paracolic, mesocolic lymph nodes); adjuvant chemotherapy was prescribed. The patient is under the supervision of an oncologist and a coloproctologist.

Conclusion. A clinical case of colorectal cancer in a woman with a long history of tobacco smoking and extra-intestinal symptoms is presented, demonstrating the need for cancer caution in relation to patients older than 50 years with iron deficiency anemia and lymphadenopathy. The timeliness of the diagnosis of a malignant neoplasm by primary care physicians is determined by the careful identification of cancer risk factors of this localization and the targeted search for “symptoms of anxiety”, upon detection of which endoscopic, radiation and morphological examination is necessary.

 

About the Authors

N. D. Potskhverashvili
Pineo Medical Ecosystem
Georgia

Nino D. Potskhverashvili — Cand. Sci. (Med.), Physician

Tbilisi, Gorgasali str., 93



N. I. Kokina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Natalia I. Kokina — Cand. Sci. (Med.), Associate Professor at the Department of Internal Disease Propaedeutics, Head of the Pulmonology Department, V.Kh. Vasilenko Clinic for Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1



E. L. Bueverova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena L. Bueverova — Cand. Sci. (Med.), Associate Professor at the Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1



O. Yu. Zolnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Oxana Yu. Zolnikova — Dr. Sci. (Med.), Professor at the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1



A. S. Cherenda
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Aleksandra S. Cherenda — Intern, Department of Internal Diseases Propaedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1



V. A. Morozova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Valeriya A. Morozova — Student

119435, Moscow, Pogodinskaya str., 1, build. 1



M. V. Feldsherov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Mikhail V. Feldsherov — Radiologist, Head of the Department of Radiation Diagnostics, University Clinical Hospital N 2

119435, Moscow, Pogodinskaya str., 1, build. 1



A. P. Kiryukhin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Andrey P. Kiryukhin — Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital N 2

119435, Moscow, Pogodinskaya str., 1, build. 1



P. V. Pavlov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Pavel V. Pavlov — Cand. Sci. (Med.), Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital N 2

119435, Moscow, Pogodinskaya str., 1, build. 1



References

1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. DOI: 10.3322/caac.21660

2. Murphy C.C., Sandler R.S., Sanoff H.K., Yang Y.C., Lund J.L., Baron J.A. Decrease in incidence of colorectal cancer among individuals 50 years or older after recommendations for population-based screening. Clin Gastroenterol Hepatol. 2017;15(6):903–9.e6. DOI: 10.1016/j.cgh.2016.08.037

3. Mamieva Z.A., Poluektova E.A., Kovaleva A.L., Shifrin O.S., Sobolev V.P., Svistushkin V.M., et al. Colorectal cancer in patient with functional gastrointestinal symptoms. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(5):66–73. (In Russ.)]. DOI: 10.22416/1382-4376-2021-31-5-66-73

4. The state of oncological care to the population of Russia in 2020. Edited by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow: P.A. Herzen Moscow State Medical Research Institute — Branch of the National Medical Research Radiological Center of the Ministry of Health of Russian Federation, 2021. (In Russ.)].

5. Xu Z., Qi F., Wang Y., Jia X., Lin P., Geng M., et al. Cancer mortality attributable to cigarette smoking in 2005, 2010 and 2015 in Qingdao, China. PLoS One. 2018;13(9):e0204221. DOI: 10.1371/journal.pone.0204221

6. Shalnova S.A., Kapustina A.V., Balanova Yu.A., Deev A.D. Smoking status and cancer mortality among Russian men and women aged 35–64. Russian Journal of Preventive Medicine. 2021;24(6):45–50. (In Russ.)]. DOI: 10.17116/profmed20212406145

7. Sollie M., Bille C. Smoking and mortality in women diagnosed with breast cancer — a systematic review with meta-analysis based on 400,944 breast cancer cases. Gland Surg. 2017;6(4):385–93. DOI: 10.21037/gs.2017.04.06

8. Pesch B., Kendzia B., Gustavsson P., Jöckel K.H., Johnen G., Pohlabeln H., et al. Cigarette smoking and lung cancer-relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer. 2012;131(5):1210–9. DOI: 10.1002/ijc.27339

9. Botteri E., Borroni E., Sloan E.K., Bagnardi V., Bosetti C., Peveri G., et al. Smoking and colorectal cancer risk, overall and by molecular subtypes: A meta-analysis. Am J Gastroenterol. 2020;115(12):1940–9. DOI: 10.14309/ajg.0000000000000803

10. Bai X., Wei H., Liu W., Coker O.O., Gou H., Liu C., et al. Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites. Gut. 2022;71(12):2439–50. DOI: 10.1136/gutjnl-2021-325021

11. Evsutina Yu.V., Drapkina O.M. The most effective colorectal cancer screening strategies. Russian Journal of Preventive Medicine. 2019;22(1):105–8. (In Russ.)]. DOI: 10.17116/profmed201922011105

12. Ivashkin V.T., Mayev I.V., Kaprin A.D., Agapov M.Yu., Andreev D.N., Vodoleev A.S., et al. Early detection of oncological diseases of the digestive system (Guidelines of the Russian Gastroenterological Association and the Russian Association of Oncologists for Primary Care Physicians). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(5):53–74. (In Russ.)]. DOI: 10.22416/13824376-2019-29-5-53-74


Review

For citations:


Potskhverashvili N.D., Kokina N.I., Bueverova E.L., Zolnikova O.Yu., Cherenda A.S., Morozova V.A., Feldsherov M.V., Kiryukhin A.P., Pavlov P.V. A Woman with a Long History of Smoking and a Debilitating Dry Cough. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(3):99-106. https://doi.org/10.22416/1382-4376-2024-34-3-99-106

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ISSN 1382-4376 (Print)
ISSN 2658-6673 (Online)