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Russian Journal of Gastroenterology, Hepatology, Coloproctology

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Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics

https://doi.org/10.22416/1382-4376-2024-34-1-58-69

Abstract

Aim: tosystematize the literature data on endoscopic semiotics and morphological changes in the gastric mucosa in autoimmune gastritis.

Key points. Autoimmune gastritis is associated with an increased risk of developing adenocarcinoma and neuroendocrine tumours of the stomach. Clarification of diagnostic criteria for autoimmune gastritis is essential for gastroenterological practice. The diagnosis is based on the results of endoscopic and histological examination, and on data from laboratory tests. Isolated atrophy of the mucous membrane of the body of the stomach, the presence of difficult-to-wash creamy mucus, changes in the mucous membrane like “shed skin”, and the presence of whitish globule-like foci are typical endoscopic signs of autoimmune gastritis. Widespread pseudopyloric metaplasia, focal intestinal and pseudopancreatic metaplasia, hyperplasia of the ridges of the mucous membrane of the body of the stomach and their relationship to the glandular layer as in the antrum allow during a morphological study considering clinical data to suspect and verify autoimmune gastritis.

Conclusion. During instrumental examination, knowledge of endoscopic symptoms and pathognomonic morphological changes is important for the timely diagnosis of autoimmune gastritis.

About the Authors

A. P. Kiryukhin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Andrey P. Kiryukhin — Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

119435, Moscow, Pogodinskaya str., 1, build. 1



A. S. Tertychnyy
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexander S. Tertychnyy — Dr.   Sci.   (Med.),   Professor, Head of the Laboratory of Electron Microscopy and Immunohistochemistry, Institute of Clinical Morphology and Digital Pathology

119435, Moscow, Pogodinskaya str., 1, build. 1



P. V. Pavlov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Pavel V. Pavlov — Cand. Sci. (Med.), Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

119435, Moscow, Pogodinskaya str., 1, build. 1



A. A. Fedorenko
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Alexandr    A.    Fedorenko    —   Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2

119435, Moscow, Pogodinskaya str., 1, build. 1



D. P. Nagornaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Darina P. Nagornaya — Postgraduate, Institute of Clinical Morphology and Digital Pathology

119435, Moscow, Pogodinskaya str., 1, build. 1



N. S. Marenich
Morozov Children's City Clinical Hospital of the Moscow Health Department
Russian Federation

Natalia S. Marenich — Endoscopist of the Endoscopy Department

119049, Moscow, 4th Dobryninskiy lane, 1/9



E. A. Losik
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Ekaterina A. Losik — Cand. Sci. (Med.), Cardiologist, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko

119435, Moscow, Pogodinskaya str., 1, build. 1



E. Yu. Yuryeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena Yu. Yuryeva — Head of the Department of Gastroenterology, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko

119435, Moscow, Pogodinskaya str., 1, build. 1



T. L. Lapina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatiana L. Lapina — Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases

119435, Moscow, Pogodinskaya str., 1, build. 1



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Review

For citations:


Kiryukhin A.P., Tertychnyy A.S., Pavlov P.V., Fedorenko A.A., Nagornaya D.P., Marenich N.S., Losik E.A., Yuryeva E.Yu., Lapina T.L. Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(1):58-69. https://doi.org/10.22416/1382-4376-2024-34-1-58-69

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ISSN 1382-4376 (Print)
ISSN 2658-6673 (Online)