Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics
https://doi.org/10.22416/1382-4376-2024-34-1-58-69
Abstract
Aim: tosystematize the literature data on endoscopic semiotics and morphological changes in the gastric mucosa in autoimmune gastritis.
Key points. Autoimmune gastritis is associated with an increased risk of developing adenocarcinoma and neuroendocrine tumours of the stomach. Clarification of diagnostic criteria for autoimmune gastritis is essential for gastroenterological practice. The diagnosis is based on the results of endoscopic and histological examination, and on data from laboratory tests. Isolated atrophy of the mucous membrane of the body of the stomach, the presence of difficult-to-wash creamy mucus, changes in the mucous membrane like “shed skin”, and the presence of whitish globule-like foci are typical endoscopic signs of autoimmune gastritis. Widespread pseudopyloric metaplasia, focal intestinal and pseudopancreatic metaplasia, hyperplasia of the ridges of the mucous membrane of the body of the stomach and their relationship to the glandular layer as in the antrum allow during a morphological study considering clinical data to suspect and verify autoimmune gastritis.
Conclusion. During instrumental examination, knowledge of endoscopic symptoms and pathognomonic morphological changes is important for the timely diagnosis of autoimmune gastritis.
About the Authors
A. P. KiryukhinRussian Federation
Andrey P. Kiryukhin — Cand. Sci. (Med.), Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
A. S. Tertychnyy
Russian Federation
Alexander S. Tertychnyy — Dr. Sci. (Med.), Professor, Head of the Laboratory of Electron Microscopy and Immunohistochemistry, Institute of Clinical Morphology and Digital Pathology
119435, Moscow, Pogodinskaya str., 1, build. 1
P. V. Pavlov
Russian Federation
Pavel V. Pavlov — Cand. Sci. (Med.), Head of the Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
A. A. Fedorenko
Russian Federation
Alexandr A. Fedorenko — Endoscopist, Department of Diagnostic and Therapeutic Endoscopy, University Clinical Hospital No. 2
119435, Moscow, Pogodinskaya str., 1, build. 1
D. P. Nagornaya
Russian Federation
Darina P. Nagornaya — Postgraduate, Institute of Clinical Morphology and Digital Pathology
119435, Moscow, Pogodinskaya str., 1, build. 1
N. S. Marenich
Russian Federation
Natalia S. Marenich — Endoscopist of the Endoscopy Department
119049, Moscow, 4th Dobryninskiy lane, 1/9
E. A. Losik
Russian Federation
Ekaterina A. Losik — Cand. Sci. (Med.), Cardiologist, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko
119435, Moscow, Pogodinskaya str., 1, build. 1
E. Yu. Yuryeva
Russian Federation
Elena Yu. Yuryeva — Head of the Department of Gastroenterology, Clinic of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology named after V.Kh. Vasilenko
119435, Moscow, Pogodinskaya str., 1, build. 1
T. L. Lapina
Russian Federation
Tatiana L. Lapina — Cand. Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Diseases
119435, Moscow, Pogodinskaya str., 1, build. 1
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Supplementary files
Review
For citations:
Kiryukhin A.P., Tertychnyy A.S., Pavlov P.V., Fedorenko A.A., Nagornaya D.P., Marenich N.S., Losik E.A., Yuryeva E.Yu., Lapina T.L. Autoimmune Gastritis: Focus on Endoscopic and Morphological Characteristics. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2024;34(1):58-69. https://doi.org/10.22416/1382-4376-2024-34-1-58-69