Steatotic Liver Disease: New Nomenclature and Its Localization in the Russian Federation

Aim: localization of the new nomenclature of steatotic liver disease in Russian clinical practice.

Key points. In 2023, international consensus decided to introduce a new nomenclature for steatotic liver disease. The article discusses the reasons for the change in nomenclature and the new terms adopted: steatotic liver disease, metabolic dysfunction-associated steatotic liver disease, metabolic dysfunction and alcohol associated steatotic liver disease. Adapting new terms to Russian healthcare poses a certain problem. The results of voting by Russian doctors on the introduction of new terms and their optimal translation are presented. A comparison of existing classifiers with new terms was carried out and the formulation of diagnoses was discussed taking into account the new nomenclature.

Conclusions. Adaptation and implementation of new nomenclature into clinical practice is an important and complex task, in which it is necessary to maintain a balance between a progressive concept and the interests of practical healthcare.

1. Rinella M.E., Lazarus J.V., Ratziu V., Francque S.M., Sanyal A.J.; Kanwal F., et al.; NAFLD Nomenclature consensus group. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966–86. DOI: 10.1097/HEP.0000000000000520

2. Rinella M.E., Neuschwander-Tetri B.A., Siddiqui M.S., Abdelmalek M.F., Caldwell S., Barb D., et al. AAS-LD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797–835. DOI: 10.1097/HEP.0000000000000323

3. ICD-11 for Mortality and Morbidity Statistics. URL: https://icd.who.int

4. Singh S., Allen A.M., Wang Z., Prokop L.J., Murad M.H., Loomba R. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: A systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13(4):643–54.e1–9. DOI: 10.1016/j.cgh.2014.04.014

5. Ludwig J., Viggiano T.R., McGill D.B., Oh B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980;55(7):434–8.

6. Eslam M., Newsome P.N., Sarin S.K., Anstee Q.M., Targher G., Romero-Gomez M., et al. A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. J Hepatol. 2020;73(1):202–9. DOI: 10.1016/j.jhep.2020.03.039

7. Raikhelson K.L., Kondrashina E.A., Pazenko E.V. Mixed steatohepatitis: More questions than answers (Part 1). Terapevticheskii arkhiv. 2020;92(12):91–6. (In Russ.). DOI: 10.26442/00403660.2020.12.200470

8. Federal Law No. 52-FZ of February 28, 2023 “On Amendments to the Federal Law “On the State Language of the Russian Federation”. (In Russ.). URL: https://publication.pravo.gov.ru/Document/View/0001202302280028

9. Ivashkin V.T., Zharkova M.S., Korochanskaya N.V., Khlynov I.B., Uspensky Yu.P. Phenotypes of non-alcoholic fatty liver disease in different regions of the Russian Federation, diagnostic and therapeutic approach in clinical practice. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2023;33(2):7–18. (In Russ.). DOI: 10.22416/1382-4376-2023-33-2-7-18

10. Tsukanov V.V., Osipenko M.F., Beloborodova E.V., Livzan M.A., Khlynov I.B., Alekseenko S.A., et al. Practical aspects of clinical manifestations, pathogenesis and therapy of alcoholic liver disease and non-alcoholic fatty liver disease: Expert opinion. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2023;33(4):7–13. (In Russ.). DOI: 10.22416/1382-4376-2023-33-4-7-13

11. Russian Scientific Medical Society of Therapists, Scientific Society of Gastroenterologists of Russia. Alcoholic liver disease (ALD) in adults: Clinical guidelines. (In Russ.). URL: https://cr.minzdrav.gov.ru/schema/711_1?ysclid=lrop8t-v3rd59729244

12. Russian Scientific Medical Society of Therapists, Scientific Society of Gastroenterologists of Russia. Non-alcoholic fatty liver disease in adults: Clinical guidelines. (In Russ.). URL: https://cr.minzdrav.gov.ru/schema/748_1?ysclid=lropb-psc6g521628496

13. Liebe R., Esposito I., Bock H.H., Vom Dahl S., Stindt J., Baumann U., et al. Diagnosis and management of secondary causes of steatohepatitis. J Hepatol. 2021;74(6):1455–71. DOI: 10.1016/j.jhep.2021.01.045

14. International Statistical Classification of Diseases and Related Health Problems (10th Revision) (ICD-10) (version 2.23 dated 07/19/2023). (In Russ.). URL: https://nsi.rosminzdrav.ru/dictionaries/1.2.643.5.1.13.13.11.1005/passport/latest

15. Lazebnik L.B., Golovanova E.V., Turkina S.V., Raikhelson K.L., Okovityy S.V., Drapkina O.M., et al. Non-alcoholic fatty liver disease in adults: Clinic, diagnostics, treatment. Guidelines for therapists, third version. Experimental and Clinical Gastroenterology. 2021;1(1):4–52. (In Russ.). DOI: 10.31146/1682-8658-ecg-185-1-4-52