Present-day pathophysiological concept of functional dyspepsia
Abstract
The aim of review. To present modern data on the pathophysiological mechanisms causing functional dyspepsia (FD) syndrome.
Key points. Nowadays FD is considered to be a complex multifactor process which cause and effect relationships are under continuous active study. Disorders of stomach motility (delay of evacuation, disorders of relaxation accommodation) and sensitivity (visceral hypersensitivity to distention) are considered to be the basic pathophysiological mechanisms of FD. These changes develop approximately in 40% of FD patients. Besides that, alteration of duodenal sensitivity to hydrochloric acid and lipids can play significant role in genesis of FD.
Conclusion. Mechanisms of FD are based on multiple heterogenous disorders of motor and sensitive functions of the stomach and duodenum. Due to major role of stomach motility disorders prokinetics are the priority drugs for treatment of FD.
About the Authors
I. V. Mayev
Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Mayev Igor V — MD, PhD, professor, vice-rector on academic activity, head of the Chair of internal diseases propedeutics and gastroenterology, corresponding member of the Russian Academy of Science, honored doctor of the Russian Federation, honored scientist of the Russian Federation
D. N. Andreev
Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Andreyev Dmitry N – assistant-professor, Chair of internal diseases propedeutics and gastroenterology
Yu. A. Kucheryavy
Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Kucheryavy Yury A – MD, lecturer, Chair of internal diseases propedeutics and gastroenterology
D. T. Dicheva
Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Dicheva Diana T — MD, lecturer, Chair of internal diseases propedeutics and gastroenterology
Yu. S. Subbotina
Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Subbotina Yuliya S – resident, Chair of internal diseases propedeutics and gastroenterology
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Mayev I.V., Andreev D.N., Kucheryavy Yu.A., Dicheva D.T., Subbotina Yu.S. Present-day pathophysiological concept of functional dyspepsia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2015;25(4):15-22. (In Russ.)
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