Discussion of irritable bowel syndrome issue and functional constipations in reports of the 21st United European Gastroenterological Week (Berlin, 2013)

Abstract

The aim of review. To discuss the reports devoted to the issue of irritable bowel syndrome (IBS) and chronic functional constipation (CFC), that were presented at the 21st United European Gastroenterological Week (Berlin, October, 14–16, 2013).

Key points. Of etiological and pathogenic factors of IBS the major attention is given now to hereditary factors, past intestinal infections, bile acids absorbtion disorders, changes of innate immune system. Differential diagnostics of IBS with other diseases (celiac sprue, chronic inflammatory bowel diseases, et al.), that may progress under a mask of the functional intestinal disorders is required. The range of pharmaceuticals has been replenished by new agents (linaclotide, prucalopride), increasing efficacy of IBS and CFC treatment.

Conclusion. Pathophysiological and clinical aspects of IBS and CFC require further investigation.