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Bacterial overgrowth syndrome

Abstract

The aim of review. To present the up-to-date information on pathogenesis, diagnostics and treatment of bacterial overgrowth syndrome (BOS).

Original positions. Now there are no general guidelines on diagnostics of bacterial overgrowth syndrome in small intestine besides there is no common opinion which diagnostic test is preferable. Intestinoscopy with aspiration of small intestinal contents and culture of aspirate should be used in the special cases. Breath tests with carbohydrate-containing substrates (lactulose, glucose, xylose), with glycocholate, hydrogen breath test have various sensitivity and specificity. Treatment of the basic disease, that provoked development of BOS, is the most important approach. Broad-spectrum antibiotics are prescribed. Application of modern enterosorbents having cytoprotective properties is proved.

About the Authors

Yu. A. Kucheryavy

Russian Federation


T. S. Oganesyan

Russian Federation


References

1. Бондаренко В.М., Мацулевич Т.В. Дисбактериоз кишечника как клинико-лабораторный синдром: современное состояние проблемы: Руководство для врачей. – М.: ГЭОТАР-Медиа, 2007. – 304 с.

2. Маев И.В., Самсонов А.А. Терапевтическая тактика при синдроме избыточного бактериального роста в тонкой кишке // Consilium Medicum. – 2007. – № 7. – С. 44–50.

3. Хендерсон Д.М. Патофизиология органов пищеварения: Пер. с англ. – 3-е изд., испр. – М.: БИНОМ; Харьков: МТК-Книга, 2005. – 272 с.

4. Щербаков П.Л. Применение энтеросорбентов в лечении дисбиоза кишечника // Эксп. клин. гастроэнтерол. – 2009. – № 3. – С. 88–92.

5. Barrett J.S., Canale K.E., Gearry R.B. et al. Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome // World J. Gastroenterol. – 2008. – Vol. 14, N 32. – P. 5020–5024.

6. Bures J., Cyrany J., Kohoutova D. et al. Small intestinal bacterial overgrowth syndrome // World J. Gastroenterol. – 2010. – Vol. 16. – P. 2978–2990.

7. Cuoco L., Salvagnini M. Small intestine bacterial overgrowth in irritable bowel syndrome: a retrospective study with rifaximin // Minerva Gastroenterol. Dietol. – 2006. – Vol. 52. – P. 89–95.

8. Di Stefano M., Miceli E., Missanelli A. et al. Absorbable vs. non-absorbable antibiotics in the treatment of small intestine bacterial overgrowth in patients with blind-loop syndrome // Aliment. Pharmacol. Ther. – 2005. – Vol. 21, N 8. – P. 985–992.

9. Gabrielli M., Lauritano E.C., Scarpellini E. et al. Bacillus clausii as a treatment of small intestinal bacterial overgrowth // Am. J. Gastroenterol. – 2009. – Vol. 104. – P. 1327–1328.

10. Justensen T., Haagen Nielsen O., Jacobson E. The normal cultivable microflora in upper jejunal fluid in healthy adults // Scand. J. Gastroneterol. – 1984. – Vol. 19. – P. 279–282.

11. Koo H.L., DuPont H.L. Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases // Curr. Opin. Gastroenterol. – 2010. – Vol. 26, N 1. – P. 17–25.

12. Lauritano E.C., Gabrielli M., Lupascu A. et al. Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth // Aliment. Pharmacol. Ther. – 2005. – Vol. 22. – P. 31–35.

13. Lauritano E.C., Gabrielli M., Scarpellini E. et al. Small intestinal bacterial overgrowth recurrence after antibiotic therapy// Am. J. Gastroenterol. – 2008. – Vol. 103. – P. 2031–2035.

14. Mcphee S.J., Papadakis M.A., Tierney L.M. Current medical diagnosis and treatment. – 4th ed. – McGraw-Hill Medical Publishing Division, 2007. – 1931 p.

15. Pimentel M. Review of rifaximin as treatment for SIBO and IBS // Expert Opin. Invest. Drugs. – 2009. – Vol. 18, N 3. – P. 349–358.

16. Quera R., Quigley E., Madrid A. Sobrecrecimiento bacteriano intestinal // Rev. Med. Chil. – 2005. – Vol. 133. – P. 1361–1370.

17. Quigley E.M. Bacteria: a new player in gastrointestinal motility disorders--infections, bacterial overgrowth, and

18. probiotics // Gastroenterol. Clin. North Am. – 2007. – Vol. 36. – P. 735–748.

19. Saad R., Chey W. Breath tests for gastrointestinal disease: the real deal or just a lot of hot air? // Gastroenterology. – 2007. – Vol. 133. – P. 1763–1766.

20. Scarpignato C., Pelosini I. Experimental and clinical pharmacology of rifaximin, a gastrointestinal selective antibiotic // Digestion. – 2006. – Vol. 73 (suppl. 1). – P. 13–27.

21. Schiffrin E.J., Parlesak A., Bode C. et al. Probiotic yogurt in the elderly with intestinal bacterial overgrowth: endotoxaemia and innate immune functions // Br. J. Nutr. – 2009. – Vol. 101. – P. 961–966.

22. Shah E.D., Basseri R.J., Chong K., Pimentel M. Abnormal breath testing in IBS: A meta-analysis // Dig. Dis. Sci. – 2010. – Vol. 55, N 9. – P. 2441–2449.

23. Simon G.L., Gorbach S.L. The human intestinal microflora // Dig. Dis. Sci. – 1986. – Vol. 31 (suppl. 9). – P. 147–162.

24. Stotzer P.O., Blomberg L., Conway P.L. et al. Probiotic treatment of small intestinal bacterial overgrowth by Lactobacillus fermentum KLD // Scand. J. Infect. Dis. – 1996. – Vol. 28. – P. 615–619.

25. Toskes P. Bacterial overgrowth of the gastrointestinal tract // Adv. Intern. Med. – 1993. – Vol. 38. – P. 387– 407.

26. Vanner S. The small intestinal bacterial overgrowth – Irritable bowel syndrome hypothesis: Implications for treatment // Gut. – 2008. – Vol. 57, N 9. – P. 1315– 1321.


Review

For citations:


Kucheryavy Yu.A., Oganesyan T.S. Bacterial overgrowth syndrome. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2010;20(5):63-68. (In Russ.)

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