Prevalence of Helicobacter pylori and GERD at Mongoloids and Caucasians of Eastern Siberia
Abstract
Aim of investigation. To study the prevalence Helicobacter pylori and gastroesophageal reflux disease (GERD) at various ethnic groups of Mongoloids and Caucasians of Eastern Siberia.
Materials and methods. Prevalence of H. pylori infection and GERD in Evenkia, Khakasia and Tuva had been studied by simultaneous (transverse) method. Frequency of heartburn was studied at 6678 Caucasians, 1445 Evenks, 2085 Khakases and 572 Tuvinians by continuous method. Esophagogastroduodenoscopy with biopsy sampling was carried out in these groups in 2125, 791, 630 and 250 patients respectively. H. pylori was determined by morphological, urease and immunoenzyme method in blood serum at 1492, 493, 533 and 414 subjects. Results. Prevalence of weekly heartburn was 6,4% in Evenks, 10,3% – in Khakases –, 12,9% – in Tuvinians, 12,3% – in Caucasians – (р1–3 < 0,001, р1–4< 0,001). Esophagitis is diagnosed in 5,4% of Caucasians, in 0,6% of Evenks, in 3,6% of Khakases, in 5,1% of Tuvinians (р 1–2< 0,001, р2–4< 0,001). Frequency of H. pylori infection in all populations was identical – about 90%.
Conclusions. Differences in prevalence of GERD were registered both between Caucasians and local population, and between various ethnic groups of Mongoloids. Between Caucasians and Mongoloids of Eastern Siberia there is no association between H. pylori infection and GERD.
About the Authors
V. V. TsukanovRussian Federation
O. V. Khomenko
Russian Federation
O. S. Rzhavicheva
Russian Federation
N. N. Butorin
Russian Federation
O. V. Shtygasheva
Russian Federation
A. S. Maady
Russian Federation
T. B. Bichurina
Russian Federation
O. S. Amelchugova
Russian Federation
References
1. Лапина Т.Л. Основные принципы диагностики Helicobacter pylori // Рос. журн. гастроэнтерол. гепатол. колопроктол. – 1999. – Т. 9, № 2. – С. 41–45.
2. Dent J., El-Serag H.B., Wallander M.A., Johansson S. Epidemiology of gastroesophageal reflux: a systematic review // Gut. – 2005. – Vol. 54, N 4. – Р. 710–717.
3. Ho K.Y., Kalng J.Y. Reflux esophagitis patients in Singapore have motor and acid exposure abnormalities similar to patients in the Western hemisphere // Am. J. Gastroenterol. – 1999. – Vol. 94, N 5. – P. 1186–1191.
4. Labenz J., Malfertheiner P. Helicobacter pylori in gastroesophageal reflux disease: causal agent, independent or protective factor? // Gut. – 1997. – Vol. 41, N 2. – Р. 277–280.
5. Lundell L.R., Dent J., Bennet J.R. Endoscopic assessment of esophagitis clinical and functional correlates and futher validation of Los-Angeles classification // Gut. – 1999. – Vol. 45. – P. 72–180.
6. Malfertheiner P., Megraud F., J’Morain C. et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report // Gut. – 2007. – Vol. 56, N 6. – P. 772–781.
7. Mahadeva S., Ramon M.C., Ford A.C. Gastroesophageal reflux is more prevalent in Western dyspeptics: a prospective comparison of British and South-East Asian patients with dyspepsia // Aliment. Pharmacol. Ther. – 2005. – Vol. 21, N 12. – Р. 1483–1490.
8. McColl K.E.L. Helicobacter pylori and esophageal cancer – not always protective // Gut. – 2007. – Vol. 56, N 2. – P. 457–459.
9. Rajendra S., Kutty K., Harunarashid H. et al. Reflux esophagitis in an ethnically mixed non-migrant population: prevalence and clinical data // Gut. – 2001. – Vol. 49, N 3. – P. 1019–1020.
10. Sharma P., Vakil N. Review article: Helicobacter pylori and reflux disease // Aliment. Pharmacol. Ther. – 2003. – Vol. 17, N 3. – Р. 297–305.
11. Shirin H., Leja M., Niv Y. Helicobacter pylori and non-malignant diseases // Helicobacter. – 2008. – Vol. 13, N 1. – P. 23–27.
12. Vakil N., van Zanden S.V., Kahrilas P. et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus // Am. J. Gastroenterol. – 2006. – Vol. 101, N 10. – P. 1900–1920.
13. Watanabe Y., Fujjiwara Y., Shiba M. Prevalence of gastroesophageal reflux disease in the Japanese population // Gastroenterology. – 2002. – Vol. 122, N 3. – P. 573–578.
Review
For citations:
Tsukanov V.V., Khomenko O.V., Rzhavicheva O.S., Butorin N.N., Shtygasheva O.V., Maady A.S., Bichurina T.B., Amelchugova O.S. Prevalence of Helicobacter pylori and GERD at Mongoloids and Caucasians of Eastern Siberia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(3):38-41. (In Russ.)
Views:
9
Email this article 
