Features of clinical course of chronic hepatites of mixed viral (HBV+HCV) etiologies
Abstract
Aim of investigation. To define the leading part of viruses B and C in pathogenesis of chronic hepatitis of mixed viral etiology.
Material and methods. Overall 249 patients (m 185, f 64) were investigated: 91 – with HBV and HCV markers (HBsAg+antiHCV) and 158 – with HBV and HDV (HBsAg+antiHDV). Mean age of patients was 38±0,4 years. At all patients level of virus B DNA, RNA and genotype of virus C, RNA of virus D by polymerase chain reaction (PCR) method were determined. Along with general clinical tests biochemical investigation of functional liver potential (bilirubin and its fractions, aminotransferase, 5-НТ, alkaline phosphatase) was done, at 48 patients biopsy specimens of liver were taken.
Results. At chronic hepatites of mixed viral etiology (HBsAg+antiHCV, HBsAg+antiHDV or their combinations) series of virologic situations which determine features of pathological process course can be observed. In the case of mixed viral etiology of chronic hepatites the hepatitis virus C with moderate viremia (59%), genotype 1b and mild clinical and morphological course of disease has leading role. At predominance of virus B replication (with and without virus D apposition) the chronic hepatitis develops with severe activity and sclerosis of porto-portal type.
Conclusion. According to clinical and virologic, biochemical and morphological analysis of results of investigation of 249 patients by chronic hepatites of the mixed viral etiology it was found out, that in relation to replicative activity of specific virus clinical course of process varies.
About the Authors
G. K. MirodzhovRussian Federation
R. I. Odinayev
Russian Federation
M. I. Sattarova
Russian Federation
N. T. Kamolova
Russian Federation
Z. D. Ramazanova
Russian Federation
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Review
For citations:
Mirodzhov G.K., Odinayev R.I., Sattarova M.I., Kamolova N.T., Ramazanova Z.D. Features of clinical course of chronic hepatites of mixed viral (HBV+HCV) etiologies. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2009;19(5):44-48. (In Russ.)
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