Changes of visceral sensitivity in patients with irritable bowel syndrome at antispasmodics treatment
Abstract
Aim of investigation. Improvement of medical tactics at irritable bowel syndrome (IBS) on the basis of comparative evaluation of clinical efficacy and effect of various pharmacological groups of spasmolytics on visceral sensitivity.
Methods. Overall 180 patients were separated into 3 groups, 60 persons in each, in relation to applied antispasmodic drug (hyoscine butylbromide 60 mg per day, or mebeverine 400 mg per day, or pinaverium 300 mg per day). Each group included 3 subgroups of 20 persons: IBS with predominance of constipations; IBS with predominance of diarrhea; IBS with predominance of pain and meteorism. Before 2-week course of treatment intensity of pain was estimated by visual-analogue scale for abdominal pain. For objectification of data on pain syndrome balloon-dilatation test was used.
Results. At IBS with predominance of a diarrhea cholineblocker has completely removed pain in 70% of patients, at IBS with predominance of constipations the sodium channels blocker has stopped pain in 65% of cases, at IBS with predominance pains and meteorism calcium channels blocker has removed pain in 40% of patients. Used drugs had no statistically significant effect on frequency of bowel movements and meteorism. At IBS with predominance of diarrhea cholineblocker has resulted in normalization of pain threshold in 65% of patients. In predominance of constipation sodium channels blockers appeared to be more effective (the normalization was achieved in 50% of patients), and at IBS with predominance pains and meteorism – calcium channels blockers (normalization in 55% of patients).
Conclusions. Cholineblockers, sodium and calcium channels blockers eliminate pain and reduce visceral sensitivity for the majority of patients with various clinical variants of IBS.
About the Authors
P. A. MakarchukRussian Federation
I. L. Khalif
Russian Federation
T. L. Mikhaylova
Russian Federation
O. V. Golovenko
Russian Federation
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Review
For citations:
Makarchuk P.A., Khalif I.L., Mikhaylova T.L., Golovenko O.V. Changes of visceral sensitivity in patients with irritable bowel syndrome at antispasmodics treatment. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(1):45-51. (In Russ.)
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