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Russian Journal of Gastroenterology, Hepatology, Coloproctology

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The Combination of Anxiety and Depressive Disorders in Patients with Irritable Bowel Syndrome (Literature Review and Expert Council Resolution)

https://doi.org/10.22416/1382-4376-2026-36-2-7-24

Abstract

Aim: to review current understanding of the role of intestinal microbiota in the pathogenesis of irritable bowel syndrome (IBS), anxiety and depressive disorders, and to present the materials of the Expert Council, which met on April 19, 2025, in Moscow.

Key points. A likely unifying factor in the development of IBS, anxiety, and depressive disorders is a change in the composition of the intestinal microbiota, which causes disruption of neuroendocrine, immune, and metabolic signaling pathways of interaction between the gut and brain (components of the gut-brain axis). The intestinal microbiota plays a coordinating role in maintaining the physiological constancy of these pathways. However, when its composition is disrupted, pathogenic mechanisms are activated, leading to the combined development of both IBS and anxiety and depressive disorders. Recent data have shown that patients with IBS, as well as those suffering from anxiety and depressive disorders, exhibit a unidirectional change in the composition of the intestinal microbiota, characterized by a decrease in the number of Bifidobacterium bacteria, suggesting their key role in the pathogenesis of these diseases. A pathogenetically substantiated therapeutic strategy for the combination of IBS and mental disorders includes modifying the gut microbiota using strain-specific pro biotics containing Bifidobacterium type species. Bifidobacterium longum 35624 and Bifidobacterium longum 1714 strains have demonstrated clinical efficacy in reducing the severity of IBS symptoms, anxiety, and depression.

Conclusion. Prescribing a combination of Bifidobacterium longum 35624 and Bifidobacterium longum 1714 probiotic strains to patients with IBS, including those with comorbid mental disorders, is clinically justified. This combination of strains holds promise for inclusion in clinical guidelines for the management of patients with irritable bowel syndrome and mental and behavioral disorders.

About the Authors

V. T. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Vladimir T. Ivashkin — Dr. Sci. (Med.), Professor, Member of the RAS, Head of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology at N.V. Sklifosovsky Institute of Clinical Medicine, Head of Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Director of the Scientific and Technological Institute of Metabolic Health; Chief Freelance Gastroenterologist of the Ministry of Health of the Russian Federation

119435, Moscow, Pogodinskaya str., 1, build. 1.


M. A. Livzan
Omsk State Medical University
Russian Federation

Maria A. Livzan — Dr. Sci. (Med.), Professor, Corresponding Member of the RAS, Head of the Department of Faculty Therapy and Professional Diseases, Rector

644099, Omsk, Lenina str., 12.


D. I. Abdulganieva
Kazan State Medical University
Russian Federation

Diana I. Abdulganieva — Dr. Sci. (Med.), Head of the Department of Hospital Therapy; Chief Freelance General Physician of the Ministry of Health of Russian Federation in the Republic of Tatarstan

420012, Kazan, Butlerova str., 49.


O. P. Alexeeva
Privolzhsky Research Medical University
Russian Federation

Olga P. Alexeeva — Dr. Sci. (Med.), Professor of the V.G. Vogralik Department of Hospital Therapy and General Practice

603005, Nizhny Novgorod, Minina i Pozharskogo sq., 10/1.


S. A. Alekseenko
Far Eastern State Medical University
Russian Federation

Sergei A. Alekseenko — Dr. Sci. (Med.), Head of the Department of Hospital Therapy

680000, Khabarovsk, Muravyova-Amurskogo str., 35.


N. V. Bakulina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation

Natalia V. Bakulina — Dr. Sci. (Med.), Professor, Head of the Department of Internal Medicine, Nephrology, General and Clinical Pharmacology with a Course of Pharmacy

195067, Saint Petersburg, Piskarevskogo ave., 47.


A. Yu. Baranovsky
St. Petersburg State University
Russian Federation

Andrey Yu. Baranovsky — Dr. Sci. (Med.), Professor, Head of the Department of Gastroenterology, Hepatology and Dietology;Chief Freelance Gastroenterologist of the Ministry of Health of Russian Federation in the Northwestern Federal District

199226, Saint Petersburg, Korablestroitelei str., 20, build. 1.


D. S. Bordin
Russian University of Medicine; Loginov Moscow Clinical Scientific Center; Tver State Medical University
Russian Federation

Dmitry S. Bordin — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology; Head of the Department of Pancreatic, Biliary and Upper Digestive Tract Disorders; Professor of the Department of General Medical Practice and Family Medicine

111123, Moscow, Entuziastov highway, 86, build. 6.


B. A. Volel
I.M. Sechenov First Moscow State Medical University (Sechenov University);Mental Health Research Centre
Russian Federation

Beatrice A. Volel — Dr. Sci. (Med.), Professor, Head of the N.V. Sklifosovsky Institute of Clinical Medicine; Leading Researcher

119991, Moscow, Trubetskaya str., 8/2.


O. Yu. Zolnikova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Oxana Yu. Zolnikova — Dr. Sci. (Med.), Professor of the Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine, Leading Researcher of the Scientific and Technological Institute of Metabolic Health; Chief Freelance Gastroenterologist of the Ministry of Health of Russian Federation in the Central Federal District

119435, Moscow, Pogodinskaya str., 1, build. 1.


K. V. Ivashkin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Konstantin V. Ivashkin — Dr. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine, Leading Researcher of the Scientific and Technological Institute of Metabolic Health

119435, Moscow, Pogodinskaya str., 1, build. 1.


N. V. Korochanskaya
Kuban State Medical University
Russian Federation

Natalia V. Korochanskaya — Dr. Sci. (Med.), Professor of the Department of Surgery No. 3; Chief Freelance Gastroenterologist of the Ministry of Health in the Krasnodar Krai

350063, Krasnodar, Mitrofana Sedina str., 4.


S. N. Mammaev
Dagestan State Medical University
Russian Federation

Suleiman N. Mammayev — Dr. Sci. (Med.), Professor of the Department of Hospital Therapy; Chief Freelance General Physician and Gastroenterologist of the Ministry of Health of Russian Federation in the North-Caucasian Federal District

367000, Makhachkala, Lenina sq., 1.


E. A. Poluektova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Elena A. Poluektova — Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine, Gastroenterologist of the Department of Chronic Intestinal and Pancreatic Diseases at the Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Leading Researcher at the Scientific and Technological Institute of Metabolic Health

119991, Moscow, Pogodinskaya str., 1, build. 1


D. V. Romanov
I.M. Sechenov First Moscow State Medical University (Sechenov University); Mental Health Research Centre
Russian Federation

Dmitry V. Romanov — Dr. Sci. (Med.), Professor, Professor of the Department of Psychiatry and Psychosomatics at the N.V. Sklifosovsky Institute of Clinical Medicine; Head of the Department of Clinical Epidemiology, Mental Health Research Centre

119991, Moscow, Trubetskaya str., 8/2.


V. V. Tsukanov
Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences
Russian Federation

Vladislav V. Tsukanov — Dr. Sci. (Med.), Professor, Head of the Clinical Department of Adult and Infant Digestive Pathology; Chief Freelance Gastroenterologist of the Ministry of Health of Russian Federation in the Siberian Federal District

660022, Krasnoyarsk, Partizana Zheleznyaka str., 3G.


O. S. Shifrin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Oleg S. Shifrin — Dr. Sci. (Med.), Professor of the Department of Disease Propaedeutics, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine, Head of the Department of Chronic Intestinal and Pancreatic Diseases at the V.Kh. Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology

119435, Moscow, Pogodinskaya str., 1, build. 1.


S. R. Abdulkhakov
Kazan State Medical University; Kazan Federal University
Russian Federation

Sayar R. Abdulkhakov — Cand. Sci. (Med.), Head of the Dpartment of Internal Diseases at the Institute of Fundamental Medicine and Biology; Associate Professor of the Department of Outpatient Therapy and General Medical Practice

420012, Kazan, Kremlyovskaya str., 18.


D. N. Andreev
Russian University of Medicine
Russian Federation

Dmitry N. Andreev — Cand. Sci. (Med.), Associate Professor of the Department of Propaedeutics of Internal Medicine and Gastroenterology

127473, Moscow, Delegatskaya str., 20, build. 1.


A. G. Beniashvili
Center for Speech Pathology and Neurorehabilitation of the Moscow Healthcare Department
Russian Federation

Allan G. Beniashvili — Cand. Sci. (Med.), Researcher

109240, Moscow, Nikoloyamskaya str., 20, build. 1.


Yu. A. Kucheryavyy
Ilyinskaya Hospital
Russian Federation

Yury A. Kucheryavyy — Cand. Sci. (Med.), Head of the Gastroenterology Department

143421, Moscow Region, Krasnogorsk Okrug, Glukhovo village, Rublevskoe Predmestye str., 2, build. 2.


I. L. Kliaritskaia
V.I. Vernadsky Crimean Federal University
Russian Federation

Irina L. Kliaritskaia — Dr. Sci. (Med.), Professor, Head of the Department of Therapy, Gastroenterology, Cardiology and General Practice (Family Medicine) at the S.I. Georgievsky Medical Academy

295017, Simferopol, Lenina blvd, 5/7.


T. L. Lapina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Tatiana L. Lapina — Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases Propedeutics, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine

119435; Moscow, Pogodinskaya str., 1, build. 1.


R. V. Maslennikov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Roman V. Maslennikov — Cand. Sci. (Med.), Associate Professor of the Department of Internal Disease Propaedeutics, Gastroenterology and Hepatology at the N.V. Sklifosovsky Institute of Clinical Medicine, Expert of the Coordination and Analytical Center for Chemical and Biological Safety, Leading Researcher of the Scientific and Technological Institute of Metabolic Health

119435, Moscow, Pogodinskaya str., 1, build. 1.


R. G. Myazin
Volgograd State Medical University
Russian Federation

Roman G. Myazin — Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine

400131, Volgograd, Pavshikh Bortsov sq., 1.


M. V. Perekalina
Stavropol Regional Clinical Hospital
Russian Federation

Marina V. Perekalina — Cand. Sci. (Med.), Head of the Gastroenterological Department; Chief Freelance Gastroenterologist of the Ministry of Health of Russian Federation in the Stavropol Territory

355002, Stavropol, Lermontova str., 208.


A. M. Sheyanov
I.M. Sechenov First Moscow State Medical University (Sechenov University); Mental Health Research Centre
Russian Federation

Andrey M. Sheyanov — Resident of the Department of Psychiatry and Psychosomatics at the N.V. Sklifosovsky Institute of Clinical Medicine;Research Assistant of the Department of Clinical Epidemiology

115522, Moscow, Kashirskoe highway, 34.


A. I. Ulyanin
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation

Anatoly I. Ulyanin — Gastroenterologist of the Department of Chronic Intestinal and Pancreatic Diseases at the V.Kh. Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology, Expert of the Coordination and Analytical Center for Chemical and Biological Safety, Junior Researcher of the Scientific and Technological Institute of Metabolic Health

119991, Moscow, Pogodinskaya str., 1, build. 1.


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Review

For citations:

Ivashkin V.T., Livzan M.A., Abdulganieva D.I., Alexeeva O.P., Alekseenko S.A., Bakulina N.V., Baranovsky A.Yu., Bordin D.S., Volel B.A., Zolnikova O.Yu., Ivashkin K.V., Korochanskaya N.V., Mammaev S.N., Poluektova E.A., Romanov D.V., Tsukanov V.V., Shifrin O.S., Abdulkhakov S.R., Andreev D.N., Beniashvili A.G., Kucheryavyy Yu.A., Kliaritskaia I.L., Lapina T.L., Maslennikov R.V., Myazin R.G., Perekalina M.V., Sheyanov A.M., Ulyanin A.I. The Combination of Anxiety and Depressive Disorders in Patients with Irritable Bowel Syndrome (Literature Review and Expert Council Resolution). Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2026;36(2):7-24. https://doi.org/10.22416/1382-4376-2026-36-2-7-24

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ISSN 1382-4376 (Print)
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Tatiana L. Lapina - MD, PhD, associate professor, Department of Internal Diseases Propedeutics,
I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
119146,  Moscow, PO box 31
e-mail: editorial@gastro-j.ru, tatlapina@gmail.com
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