Decreased Bone Mineralization in Children with Inflammatory Bowel Diseases
https://doi.org/10.22416/1382-4376-2025-35-1856-5180
Abstract
Aim: to assess bone mineral density (BMD) in children with inflammatory bowel diseases (IBD) and analyse the factors influencing it.
Materials and methods. The study included 113 patients with IBD (58 with Crohn’s disease and 55 with ulcerative colitis) and 61 healthy children (control group). All the participants had a comprehensive assessment of BMD by means of dual-energy X-ray absorptiometry (DEXA), as well as measurement of vitamin D levels, biochemical markers of bone metabolism, dietary calcium intake, and physical activity.
Results. Decreased BMD of varying degrees was identified in 39.8 % of patients with IBD, which is substantially more frequent than in the control group (p = 0.001). Significant predictors of decreased BMD were established: disease duration exceeding 3 years, high clinical and endoscopic activity, low calcium intake (Ме) 300 mg/day vs 550 mg/day in the control group (р < 0.001), and dose-dependent effect of glucocorticoid therapy.
Conclusion. Low bone mass build-up in children with IBD is a multifactorial process associated with disease activity and duration, dietary restrictions, and treatment modalities, underscoring the need for multidisciplinary monitoring of bone tissue status in this patient group.
About the Authors
M. I. Erokhina
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region
Russian Federation
Russian Federation
Maria I. Erokhina — Researcher at the Department of Pediatrics, a gastroenterologist at the Department of Gastroenterology
141009, Mytishchi, Kominterna str., 24A, build. 1
N. D. Odinaeva
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region ; Moscow Regional Research and Clinical Institute
Russian Federation
Russian Federation
Niso D. Odinaeva — Dr. Sci. (Med.), Director; Professor of the Department of Pediatrics
141009, Mytishchi, Kominterna str., 24A, build. 1
E. I. Kondratуeva
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region ; Research Center for Medical Genetics
Russian Federation
Russian Federation
Elena I. Kondratуeva — Dr. Sci. (Med.), Professor, Deputy Director; Head of the Scientific and Clinical Department of Cystic Fibrosis, Head of the Department of Genetic and Respiratory Diseases, Institute of Higher and Continuing Professional Education
141009, Mytishchi, Kominterna str., 24A, build. 1
A. I. Khavkin
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region ; Belgorod State National Research University
Russian Federation
Russian Federation
Anatoly I. Khavkin— Dr. Sci. (Med.), Professor, Head of the Department of Gastroenterology and Dietetics named after A.V. Mazurin; Professor of the Department of Pediatrics with a Course in Pediatric Surgical Diseases, Medical Institute
141009, Mytishchi, Kominterna str., 24A, build. 1
E. A. Yablokova
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region ; I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Ekaterina A. Yablokova — Cand. Sci. (Med.), Docent, Senior Researcher at the Department of Pediatrics; Associate Professor at the Department of Pediatric Diseases, N.F. Filatov Clinical Institute of Children's Health
141009, Mytishchi, Kominterna str., 24A, build. 1
E. K. Zhekaite
Research Clinical Institute of Childhood of the Ministry of Healthcare of the Moscow Region
Russian Federation
Russian Federation
Elena K. Zhekaite — Cand. Sci. (Med.), Senior Researcher at the Department of Hereditary and Metabolic Diseases, Pediatrician at the Cystic Fibrosis Department
141009, Mytishchi, Kominterna str., 24A, build. 1
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For citations:
Erokhina M.I., Odinaeva N.D., Kondratуeva E.I., Khavkin A.I., Yablokova E.A., Zhekaite E.K. Decreased Bone Mineralization in Children with Inflammatory Bowel Diseases. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2025;35(6):72-86. https://doi.org/10.22416/1382-4376-2025-35-1856-5180
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