Primary pancreatic lymphoma
Abstract
Aim of the review. To present data on epidemiology, etiology and pathogenesis, diagnostics and treatment of rare type of lymphoma: primary lymphoma of the pancreas.
The recent literature data. Lymphocytic lymphomas (non-Hodgkin's lymphomas) have lymphoreticular origin and include plenty of types distinguished by cellular origin, clinical presentation, localization and prevalence, response to treatment. Extranodular nonHodgkin's lymphomas have frequency of 30 to 40% of all lymphocytic lymphomas cases, gastro-intestinal neoplasms are diagnosed approximately in half of these cases. The stomach and small intestine are the most frequently affected of digestive organs. Lesion of the pancreas can be both solitary (primary), and due to neoplastic infiltration from adjacent organs involved in neoplastic process, as well as from the lymph nodes. Clinical signs, data of laboratory and instrumental investigation at primary pancreatic lymphoma (PPL) are nonspecific. Diagnostics is based on morphological study of bone marrow and neoplastic tissue. The special difficulties occur at differentiation with pancreatic cancer. Well-timed detection of PPL helps to avoid extremely invasive surgery as the tumor is highly sensitive to chemotherapy.
Conclusion. Primary pancreatic lymphomas are responsible for only 0,5–0,9% of all pancreatic tumors and, as a rule, present themselves as a focal lesion which should be differentiated with pancreatic cancer. Their early diagnostics allows to resort to chemotherapy with favorable prognosis.
About the Authors
I. V. MayevRussian Federation
A. S. Trukhmanov
Russian Federation
V. A. Doronin
Russian Federation
Yu. A. Kucheryavy
Russian Federation
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For citations:
Mayev I.V., Trukhmanov A.S., Doronin V.A., Kucheryavy Yu.A. Primary pancreatic lymphoma. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(3):48-61. (In Russ.)
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