New potentials of chronic diarrhea treatment
Abstract
The aim of review. To analyze basic groups of drugs used for symptomatic treatment of chronic diarrhea.
Recent data of the literature. At the moment both well-known groups of antidiarrheal drugs (obducting agents, m-), and relatively new antidiarrheal agents (5-НТ3-receptor antagonists, d-opioid receptors agonists) are applied for symptomatic treatment of chronic diarrhea.
Conclusion. Despite of high number of proposed antidiarrheal preparations, range of drugs substantially used for symptomatic treatment of chronic diarrhea remains narrow enough. New drug groups having potential antidiarrheal effect, require further studying.
References
1. Парфенов А.И., Ручкина И.Н., Осипов Г.А. Висмута трикалия дицитрат в лечении больных постинфекционным синдромом раздраженного кишечника // Рус. мед. журн. – 2006. – № 2. – С. 3–6.
2. Ericsson C.D. Nonantimicrobial agents in the prevention and treatment of travelers diarrhea // Clin. Infect. Dis. – 2005. – Vol. 41 (suppl. 8). – P. 557–563.
3. Farthing M.J.G. Antisecretory drugs for diarrheal disease // Recent advances in gastrointestinal pharmacology and therapeutics / Eds. C.D. Scarpignato, F. Mario. – Basel, 2006. – P. 74–93.
4. Fine K.D., Lee E.L. Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis // Gastroenterology. – 1998. – Vol. 114. – P. 29–36.
5. Hammer H.F. Intractable diarrhea // Syllabus of the postgraduate teaching program. – 15 United European Gastroenterology Week. – Paris, 2007. – P. 161–163.
6. Lembo A. Peripheral opioids for functional GI disease: a reappraisal // Recent advances in gastrointestinal pharmacology and therapeutics / Eds. C.D. Scarpignato, F. Mario. – Basel, 2006. – P. 151–164.
7. Rao G., Aliwalas G., Slaymaker E., Brown B. Bismuth revisited an effective way to prevent traveler’s diarrhea // J. Travel Med. – 2004. – Vol. 11. – P. 239–242.
8. Schiller L.R., Sellin J.H. Diarrhea // Sleisenger & Fordtran’s gastrointestinal and liver disease / Eds. M. Feldman, L. Friedman, M.H. Sleisenger. – 7th Ed. – Philadelphia–London–New York–St. Louis–Sydney–Toronto, 2002. – Vol. 1. – P. 131–153.
9. Stroehlein J.R. Microcopic colitis // Curr. Treat. Options Gastroenterol. – 2007. – Vol. 3. – P. 231–236.
10. Tonini M., Pace F. Drugs acting on serotonin receptors for the treatment of functional GI disorders // Recent advances in gastrointestinal pharmacology and therapeutics / Eds. C.D. Scarpignato, F. Mario. – Basel, 2006. – P. 95–113.
11. Wall G.C., Schirmer L.L., Page M.J. Pharmacotherapy for microscopic colitis // Pharmacotherapy. – 2007. – Vol. 27. – P. 425–433.
Review
For citations:
Sheptulin A.A. New potentials of chronic diarrhea treatment. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(3):62-65. (In Russ.)
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