Interleukin-1b allelic polymorphism at H. pylori infection
Abstract
The aim of review. To analyze literature data on the role of genetic polymorphism of interleukin-1b in development and course of H. pylori infection.
Recent literature data. Now a key question of H. pylori infection is the potential of the microorganism to induce such diverse diseases, as duodenal peptic ulcer and stomach cancer. A basis of H. pylori infection pathogenesis is inflammation of the stomach mucosa. In development of any inflammatory process, and also in its outcome the balance of production, expression and inhibition of synthesis of interleukin-1 protein family plays important (if not the main) role. Today it is proved, that the various levels of interleukin-1 production are related to the presence of certain alleles.
Conclusion. Genetic polymorphism of interleukin-1 family has essential effect on course, outcomes and finally on the treatment of Helicobacter pylori infection.
About the Authors
I. V. MayevRussian Federation
Yu. A. Kucheryavy
Russian Federation
T. S. Oganesyan
Russian Federation
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Review
For citations:
Mayev I.V., Kucheryavy Yu.A., Oganesyan T.S. Interleukin-1b allelic polymorphism at H. pylori infection. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(5):4-11. (In Russ.)
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