Options of trimebutine application in treatment of irritable bowel syndrome
Abstract
The aim of review. To describe basic mechanisms of development of abdominal pain and methods of its relief.
Recent literature data. Chronic abdominal pain (CAP) is one of the most frequent causes of visits to general practitioner. Within the most frequent causes, irritable bowel syndrome (IBS), which is related to functional disorders (FD) of gastro-intestinal tract (GIT), occupies the third place. Stress, chronic psychological overload promoting misbalance of neurotransmitters (enkephalines, serotonin, cholecystokinin, etc.) are defined as pathogenic mechanisms of FD, including IBS. Intestinal wall receptors sensivity threshold determines perception of pain and motor function of intestine. Trimebutine interreacts with m-, d - and k-enkephaline receptors, promotes normalization of intestinal motility, relief of flatulence and stomach distention, increases pain threshold in large intestine. It also has beneficial effect both at hypokinetic, and at hyperkinetic forms of motor disorders.
Conclusion. Treatment of the patient with abdominal pain should be complex and strictly individual. Trimebutine is a promising agent of pathogenic therapy of IBS and other functional GIT disorders related to hyperalgesia.
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Review
For citations:
Ivashkin V.Т., Drapkina O.M. Options of trimebutine application in treatment of irritable bowel syndrome. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(5):12-16. (In Russ.)
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