Morphological diagnostics of extrahepatic biliary atresia
Abstract
Aim of investigation. To study morphological changes of liver biopsy specimen at extrahepatic biliary atresia (EHBA) in relations to age of patients and to reveal clinical and morphological interrelations.
Stuff and methods. 30 children with EHBA aged 26 to 102 days were investigated. Severity of pathological processes in the liver was determined by Knodell histological activity index. Desmet score was used for evaluation of fibrosis stage.
Results. Various severity of cholestasis and proliferation of bile ducts, dependent on age of patient was determined. All children had low or minimum degree of histological activity of inflammation by Knodell index. Direct correlation of fibrosis severity to age of the patient (r=0,92, p<0,05) was revealed. The strong negative correlation between level of serum gamma-glutamyltranspeptidase (GGT) and severity of fibrosis according to Desmet score (r=0,93, p <0,05) was determined.
Conclusions. The degree of cholestasis, proliferation of bile ducts and prevalence of fibrosis at EHBA was proportional to age of a child. Intensity of inflammation does not depend on age. According to clinical and morphological interrelation analysis diagnostic value of GGT level was established. No other clinical or laboratory parameters significantly exhibiting degree of morphological changes at EHBA were revealed.
About the Authors
A. V. DegtyaryovaRussian Federation
Ye. L. Tumanova
Russian Federation
A. Yu. Razumovsky
Russian Federation
Ye. A. Tashirova
Russian Federation
M. B. Albegova
Russian Federation
Yu. G. Mukhina
Russian Federation
N. N. Volodin
Russian Federation
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Review
For citations:
Degtyaryova A.V., Tumanova Ye.L., Razumovsky A.Yu., Tashirova Ye.A., Albegova M.B., Mukhina Yu.G., Volodin N.N. Morphological diagnostics of extrahepatic biliary atresia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2008;18(5):54-61. (In Russ.)
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